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View Structure Prediction Details

Protein: CYC2
Organism: Saccharomyces cerevisiae
Length: 404 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYC2.

Description E-value Query
Range
Subject
Range
NIA_LOTJA - Nitrate reductase [NADH] OS=Lotus japonicus GN=NIA PE=3 SV=1
2.0E-81 [30..399] [576..895]
NIA2_PHAVU - Nitrate reductase [NADH] 2 OS=Phaseolus vulgaris GN=NIA2 PE=3 SV=1
4.0E-81 [30..399] [568..885]
gi|2731816 - gi|2731816|gb|AAB93560.1| nitrate reductase [Glycine max]
1.0E-79 [30..399] [558..871]
gi|11119241 - gi|11119241|gb|AAG30576.1|AF314093_1 nitrate reductase [Ricinus communis]
2.0E-79 [30..399] [589..909]
NIA_CUCMA - Nitrate reductase [NADH] OS=Cucurbita maxima PE=2 SV=1
3.0E-79 [30..399] [598..913]
gi|14041825 - gi|14041825|dbj|BAB55002.1| nitrate reductase [Prunus persica]
8.0E-79 [30..396] [579..898]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-78 [30..399] [566..879]
gi|484212 - gi|484212|gb|AAA33712.1| nitrate reductase apoenzyme
2.0E-78 [30..399] [596..910]

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Predicted Domain #1
Region A:
Residues: [1-90]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSENSLNPS EKYNFEECNV LKEPFKNRKE ETKKRKSSML WKNYVLSSSR ITRRLHKSPR  60
   61 KSSFSKNFFI TGCLLTVGAV SSYLTYRYTS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.274 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.271 a.4.12 TrpR-like
View Download 0.331 f.15.1 Small-conductance potassium channel
View Download 0.393 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.261 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.254 a.150.1 Anti-sigma factor AsiA
View Download 0.254 c.3.1 FAD/NAD(P)-binding domain
View Download 0.248 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.245 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.220 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.219 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.215 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.202 d.58.17 Metal-binding domain
View Download 0.202 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain

Predicted Domain #2
Region A:
Residues: [91-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERENKHELSP SYFVKYKISH KRDIDSSHFL LEVTPLFKQK VNIWSLMTAE NLWSVEIKQP  60
   61 EVMVVRNYTP LPLKFNPASK EIEILKDGDN ADGKLSFYIK KYENGEVARW LHHLPKGHII 120
  121 EIRGPFIDYE FPHL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.045757
Match: 1ndh__
Description: cytochrome b5 reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [225-404]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNELKRSRDC LYMDNRNERG NNVRENSQFI YQPYDIMMFT AGTGIVTALQ LLLTESPFRG  60
   61 TIKLFHTDKN IKQLGPLYPI LLRLQASNRV QLKIFETDRQ TKQDVLKSIQ KSITKPYPYK 120
  121 GLLPFSNVNN KNIMPVLALV CGPESYISSI SGRKYDLNQG PVGGLLSKEG WNSDNVYKLS 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.045757
Match: 1ndh__
Description: cytochrome b5 reductase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle