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View Structure Prediction Details

Protein: CDC33
Organism: Saccharomyces cerevisiae
Length: 213 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC33.

Description E-value Query
Range
Subject
Range
EIF4E - eukaryotic translation initiation factor 4E
gi|60819169, gi|... - gi|61363092|gb|AAX42333.1| eukaryotic translation initiation factor 4E [synthetic construct], gi|608...
gi|90078144 - gi|90078144|dbj|BAE88752.1| unnamed protein product [Macaca fascicularis]
ENSPTRT00000030331 - null
HGNC:3287|MIM:13... - translation initiation factor 4E
gi|109075052 - gi|109075052|ref|XP_001104976.1| PREDICTED: similar to Eukaryotic translation initiation factor 4E (...
3.0E-74 [1..210] [1..211]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-74 [2..210] [13..225]
IF4E_BOVIN - (Q9N0T5) Eukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNA cap-binding protein)
5.0E-74 [1..210] [1..211]
IF4E_RABIT - Eukaryotic translation initiation factor 4E OS=Oryctolagus cuniculus GN=EIF4E PE=1 SV=1
6.0E-74 [1..210] [1..211]
gi|7546557, gi|7... - gi|7546560|pdb|1EJH|D Chain D, Eif4eEIF4G PEPTIDE7-Methyl-Gdp, gi|7546559|pdb|1EJH|C Chain C, Eif4eE...
2.0E-73 [29..210] [2..184]
IF4E_XENLA - Eukaryotic translation initiation factor 4E OS=Xenopus laevis GN=eif4e PE=1 SV=1
2.0E-73 [3..210] [1..207]
gi|5059071 - gi|5059071|gb|AAD38903.1|AF128806_1 cap binding protein eIF-4E [Oryzias latipes]
1.0E-72 [14..210] [10..207]
gi|151945497 - gi|151945497|gb|EDN63738.1| eIF-4E [Saccharomyces cerevisiae YJM789]
ORFP:19795 - YOL139C, Contig c315 2759-3400 reverse complement
IF4E_YEAST - Eukaryotic translation initiation factor 4E OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
CDC33 - Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex ...
gi|190407214 - gi|190407214|gb|EDV10481.1| mRNA cap binding protein eIF-4E [Saccharomyces cerevisiae RM11-1a]
gi|207341469 - gi|207341469|gb|EDZ69517.1| YOL139Cp-like protein [Saccharomyces cerevisiae AWRI1631]
6.0E-72 [1..213] [1..213]

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Predicted Domain #1
Region A:
Residues: [1-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVEEVSKKF EENVSVDDTT ATPKTVLSDS AHFDVKHPLN TKWTLWYTKP AVDKSESWSD  60
   61 LLRPVTSFQT VEEFWAIIQN IPEPHELPLK SDYHVFRNDV RPEWEDEANA KGGKWSFQLR 120
  121 GKGADIDELW LRTLLAVIGE TIDEDDSQIN GVVLSIRKGG NKFALWTKSE DKEPLLRIGG 180
  181 KFKQVLKLTD DGHLEFFPHS SANGRHPQPS ITL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1242.69897
Match: 1ap8__
Description: Translation initiation factor eIF4e
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 12.6022960879923 bayes_pls_golite062009
RNA cap binding 8.70938037002519 bayes_pls_golite062009
translation factor activity, nucleic acid binding 7.91586572659635 bayes_pls_golite062009
translation regulator activity 7.87578736455963 bayes_pls_golite062009
RNA binding 6.31187636707846 bayes_pls_golite062009
binding 3.48071223822752 bayes_pls_golite062009
nucleic acid binding 3.46353214508261 bayes_pls_golite062009
protein binding 0.850113401405075 bayes_pls_golite062009
RNA 7-methylguanosine cap binding 0.544036568660606 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle