YRC Public Data Repository - Protein Structure Prediction

Protein:	MCH4
Organism:	Saccharomyces cerevisiae
Length:	501 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCH4.

Description	E-value	Query Range	Subject Range
MCH4 - Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of m... MCH4_YEAST - Probable transporter MCH4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCH4 PE=1 SV=1	3.0E-67	[1..501]	[1..501]
gi\|12658422 - gi\|12658422\|gb\|AAK01131.1\|AF331922_2 putative hexuronate transporter [Xanthomonas oryzae pv. oryzae]	4.0E-62	[28..490]	[19..478]
ANTR1_ARATH - Sodium-dependent phosphate transport protein 1, chloroplastic OS=Arabidopsis thaliana GN=ANTR1 PE=1 ...	4.0E-61	[3..493]	[11..511]
gi\|8979037, gi\|1... - gi\|8979037\|dbj\|BAA98872.1\| hexosphosphate transport [Chlamydophila pneumoniae J138], gi\|15836197\|ref... gi\|33242022, gi\|... - gi\|33242022\|ref\|NP_876963.1\| hexose phosphate transport system regulatory protein [Chlamydophila pne... UHPT_CHLPN - Probable hexose phosphate transport protein OS=Chlamydia pneumoniae GN=uhpC PE=3 SV=1 gi\|7189017, gi\|1... - gi\|7189017\|gb\|AAF37968.1\| GlpT/PgpT/UhpT family protein [Chlamydophila pneumoniae AR39], gi\|16752375... gi\|4376965, gi\|1... - gi\|4376965\|gb\|AAD18804.1\| Hexosphosphate Transport [Chlamydophila pneumoniae CWL029], gi\|15618575\|re...	5.0E-57	[83..487]	[18..444]
gi\|9657525, gi\|1... - gi\|9657525\|gb\|AAF96050.1\| glycerol-3-phosphate transporter [Vibrio cholerae O1 biovar eltor str. N16... gi\|11277446 - pir\|\|C82495 glycerol-3-phosphate transporter VCA0137 [imported] - Vibrio cholerae (strain N16961 ser...	6.0E-57	[84..490]	[32..456]
gi\|229894922, gi... - gi\|229894922\|ref\|ZP_04510100.1\| putative integral membrane protein [Yersinia pestis Pestoides A], gi... gi\|229694002, gi... - gi\|229897665\|ref\|ZP_04512821.1\| putative integral membrane protein [Yersinia pestis biovar Orientali... gi\|229688600, gi... - gi\|229898310\|ref\|ZP_04513457.1\| putative integral membrane protein [Yersinia pestis biovar Orientali... gi\|167056164, gi... - gi\|167424977\|ref\|ZP_02316730.1\| transporter, major facilitator family [Yersinia pestis biovar Mediae... gi\|166962059, gi... - gi\|167420364\|ref\|ZP_02312117.1\| transporter, major facilitator family [Yersinia pestis biovar Orient... gi\|167467739 - gi\|167467739\|ref\|ZP_02332443.1\| transporter, major facilitator family protein [Yersinia pestis FV-1] gi\|165913807, gi... - gi\|89102527\|ref\|ZP_01175154.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|166010770, gi... - gi\|166010770\|ref\|ZP_02231668.1\| transporter, major facilitator family [Yersinia pestis biovar Antiqu... gi\|108807591, gi... - gi\|108807591\|ref\|YP_651507.1\| putative integral membrane protein [Yersinia pestis Antiqua], gi\|10877... gi\|165920648, gi... - gi\|165927382\|ref\|ZP_02223214.1\| transporter, major facilitator family [Yersinia pestis biovar Orient... gi\|108811867, gi... - gi\|229902169\|ref\|ZP_04517290.1\| putative integral membrane protein [Yersinia pestis Nepal516], gi\|22... gi\|167049621, gi... - gi\|167400768\|ref\|ZP_02306274.1\| transporter, major facilitator family [Yersinia pestis biovar Antiqu... gi\|166208316, gi... - gi\|166211136\|ref\|ZP_02237171.1\| transporter, major facilitator family [Yersinia pestis biovar Antiqu... gi\|25510657 - pir\|\|AG0272 probable integral membrane protein YPO2237 [imported] - Yersinia pestis (strain CO92) gi\|149292257, gi... - gi\|149365844\|ref\|ZP_01887879.1\| putative integral membrane protein [Yersinia pestis CA88-4125], gi\|1... gi\|45441835, gi\|... - gi\|45441835\|ref\|NP_993374.1\| putative integral membrane protein [Yersinia pestis biovar Microtus str... gi\|77636254, gi\|... - gi\|77636254\|ref\|ZP_00798330.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|145209891, gi... - gi\|145598195\|ref\|YP_001162271.1\| integral membrane protein [Yersinia pestis Pestoides F], gi\|1452098... gi\|22125968, gi\|... - gi\|22125968\|ref\|NP_669391.1\| transport protein [Yersinia pestis KIM], gi\|21958911\|gb\|AAM85642.1\|AE01... gi\|16122465, gi\|... - gi\|218929333\|ref\|YP_002347208.1\| putative integral membrane protein [Yersinia pestis CO92], gi\|16122...	2.0E-55	[71..492]	[1..434]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-55	[84..486]	[12..442]
gi\|3834395 - gi\|3834395\|gb\|AAC70919.1\| monocarboxylate transporter 2; MCT2 [Homo sapiens]	6.0E-55	[79..492]	[2..427]
PCAK_ACIAD - 4-hydroxybenzoate transporter PcaK OS=Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) GN=pca...	6.0E-55	[65..473]	[3..434]

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Predicted Domain #1

Region A:
Residues: [1-87]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNIPIIANS KRFLFSKDHE AQSTRDHDVE LETREGPSSG YNPNFNAADA ILKKNSDQVD  60
   61 LDVNKLTNVT SRVLNTPEAS LIYDDDR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.274	0.460	monocarboxylic acid transmembrane transporter activity	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.244	0.053	monocarboxylic acid transmembrane transporter activity	a.60.1	SAM/Pointed domain
View	Download	0.271	0.045	monocarboxylic acid transmembrane transporter activity	a.74.1	Cyclin-like
View	Download	0.307	0.010	monocarboxylic acid transmembrane transporter activity	a.130.1	Chorismate mutase II
View	Download	0.260	0.009	monocarboxylic acid transmembrane transporter activity	a.137.9	Quinohemoprotein amine dehydrogenase C chain
View	Download	0.307	N/A	N/A	a.130.1	Chorismate mutase II
View	Download	0.274	N/A	N/A	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.271	N/A	N/A	a.74.1	Cyclin-like
View	Download	0.260	N/A	N/A	a.137.9	Quinohemoprotein amine dehydrogenase C chain
View	Download	0.244	N/A	N/A	a.60.1	SAM/Pointed domain
View	Download	0.236	N/A	N/A	d.42.1	POZ domain
View	Download	0.231	N/A	N/A	d.95.2	Homing endonucleases
View	Download	0.219	N/A	N/A	d.206.1	YggU-like

Predicted Domain #2

Region A:
Residues: [88-501]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFPDGGLKAW LVVFGAFMGL VPVFGLINSL GAIESYISKH QLANISSSTI SWIFSLYLAI  60
   61 SFLSCILSGG YFDRNGSIGL MCTGTVIYAG GLFALANCKS VWQFILAFSV CSGLGTGILM 120
  121 TPLIGTVATW FLKRRGIATS ISTMGGSIGG IVFPIMLRKL YKEVGFQWAI RILSFICLTC 180
  181 LICASVLARE RTKPVVQPFK SKAEVAKWYI SSVFNWRYFL EGKFLFVAIG ASFAESSLTS 240
  241 CATYLASYSM TRGNTENVAY TMITASNAVG ILGRYIPGYF ADKFIGRFNV EIITISMAAL 300
  301 FNFVMWLPFG GNTKVLWAYV CLWGFSTGSI LSLTPVCIGQ ISKTTDFGKR YATVYLLQAL 360
  361 VTIPVLPIGG TLIGKGTVAN YNHFIIFNSA LMAAGAACYI ISRHICVGAK LCKF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.09691
Match:	1lviA_
Description:	No description for 1lviA_ was found.

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transporter activity	3.3426261924492	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.29689809004391	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
ion transmembrane transporter activity	1.94035843948137	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
cation transmembrane transporter activity	1.5181741634556	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
binding	0.873217664940684	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: