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View Structure Prediction Details

Protein: WSC3
Organism: Saccharomyces cerevisiae
Length: 556 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for WSC3.

Description E-value Query
Range
Subject
Range
TCNA_TRYCR - Sialidase OS=Trypanosoma cruzi GN=TCNA PE=2 SV=1
6.0E-57 [11..556] [568..1112]
gi|15828996 - gi|15828996|ref|NP_326356.1| lipoprotein VSAC (fragment) [Mycoplasma pulmonis UAB CTIP]
gi|14089939, gi|... - pir||E90577 lipoprotein vsaC [imported] - Mycoplasma pulmonis (strain UAB CTIP) (fragment), gi|14089...
4.0E-55 [14..555] [200..748]
gi|9695347 - gi|9695347|gb|AAF97432.1|U23947_9 VsaC1 [Mycoplasma pulmonis]
2.0E-53 [62..556] [6..508]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-49 [16..556] [250..799]
SPBPJ4664.02 - glycoprotein
YHU2_SCHPO - Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 OS=Schizosaccharomyces pombe (str...
7.0E-48 [7..556] [1599..2152]
MUC4 - mucin 4, cell surface associated
8.0E-36 [9..535] [78..607]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERVWFAKLT NKGTIKIGYI SFILLSLLCQ SLIGLVNADF NYEGCYSAAD IQSAGLSLKN  60
   61 SYIYQSVSYC QNQCPESAVV ALFNGSDCYC GNSVSFLTSL TKSTDSNCGT KC

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 22.251812
Match: PF01822
Description: WSC domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.330 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.311 N/A N/A d.95.2 Homing endonucleases
View Download 0.293 N/A N/A d.134.1 Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View Download 0.273 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.271 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

Predicted Domain #2
Region A:
Residues: [113-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGWPYQMCGG SSYMNVYVNA ETFVSSVESS SSKEGSSTSY MPSTTSSLSS AQISSTTRRT  60
   61 S

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.96
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [174-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDMKSSEMIA TTVSTTSTTS SSTSSTTSST TSSTTSSTTS STTSSSTSST TSSTTSSTTS  60
   61 STTSSTTSST TSSTTSSTTS STTSIFSVTS SSSSITLSSS EHTTVDSRTS SPSSTLVPVS 120
  121 SSSSTLSTPK VTSMTPSTSS TIPIVTSVEL VTSVVTKAIV STSDQHQETI FVTRTSVVER 180
  181 SSEVATATAA ASNNRSNSTS KQRLSGGAIA GIVIGVVFGV IFIILILLFL IWRRRKSHDQ 240
  241 LDLEETKHYQ PYSFGDEDAN PIGPPPSSGT TNWMRHSRGN TAGSIGTSNM YGFSMSNGAN 300
  301 YS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 12.06
Match: 1ei3A
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [476-556]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSSNTSGSI INNLAGLQDA TVQKQNLPST VFEEANTLNS ANERFSANSL PDMMMSGPLQ  60
   61 VVNPDNPDNP ELSSTVSHNR A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.540 0.936 response to heat a.4.5 "Winged helix" DNA-binding domain
View Download 0.451 0.936 response to heat a.35.1 lambda repressor-like DNA-binding domains
View Download 0.364 0.936 response to heat a.65.1 Annexin
View Download 0.365 0.936 response to heat a.2.3 Chaperone J-domain
View Download 0.410 0.936 response to heat a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.355 0.936 response to heat a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.350 0.936 response to heat a.64.2 Bacteriocin AS-48
View Download 0.346 0.936 response to heat a.145.1 Flagellar transcriptional activator FlhD
View Download 0.343 0.936 response to heat a.64.1 Saposin
View Download 0.291 0.936 response to heat a.7.6 Ribosomal protein S20
View Download 0.274 0.936 response to heat a.4.1 Homeodomain-like
View Download 0.271 0.936 response to heat c.23.3 Hypothetical protein MTH538
View Download 0.265 0.936 response to heat a.4.5 "Winged helix" DNA-binding domain
View Download 0.265 0.936 response to heat a.4.5 "Winged helix" DNA-binding domain
View Download 0.259 0.936 response to heat f.14.1 Voltage-gated potassium channels
View Download 0.258 0.936 response to heat a.91.1 Regulator of G-protein signalling, RGS
View Download 0.252 0.936 response to heat d.70.1 Yest killer toxins
View Download 0.211 0.936 response to heat d.68.7 R3H domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle