YRC Public Data Repository - Protein Structure Prediction

Protein:	TPT1
Organism:	Saccharomyces cerevisiae
Length:	230 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPT1.

Description	E-value	Query Range	Subject Range
TPT1_YEAST - tRNA 2'-phosphotransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPT1 PE=1 SV=... TPT1 - tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-...	2.0E-78	[1..230]	[1..230]
KPTA_THEAC - Probable RNA 2'-phosphotransferase OS=Thermoplasma acidophilum GN=kptA PE=3 SV=2 KPTA_THEAC - Probable RNA 2'-phosphotransferase OS=Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9...	1.0E-57	[3..224]	[24..231]
KPTA_THEVO - Probable RNA 2'-phosphotransferase OS=Thermoplasma volcanium GN=kptA PE=3 SV=1 KPTA_THEVO - Probable RNA 2'-phosphotransferase OS=Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 957...	6.0E-57	[3..224]	[24..231]
KPTA_PYRHO - Probable RNA 2'-phosphotransferase OS=Pyrococcus horikoshii GN=kptA PE=3 SV=1 KPTA_PYRHO - Probable RNA 2'-phosphotransferase OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 99...	7.0E-56	[11..202]	[2..177]
KPTA_PYRAB - Probable RNA 2'-phosphotransferase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=kptA PE=3 SV=1 KPTA_PYRAB - Probable RNA 2'-phosphotransferase OS=Pyrococcus abyssi GN=kptA PE=3 SV=1	2.0E-55	[8..198]	[5..179]
KPTA_THEAC - Probable RNA 2'-phosphotransferase OS=Thermoplasma acidophilum GN=kptA PE=3 SV=2 KPTA_THEAC - Probable RNA 2'-phosphotransferase OS=Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9...	2.0E-55	[6..224]	[1..205]
SPAC2C4.12c - tRNA 2'-phosphotransferase Tpt1 TPT1_SCHPO - Putative tRNA 2'-phosphotransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC2C...	8.0E-55	[10..217]	[33..231]
gi\|25520148, gi\|... - gi\|25524258\|pir\|\|AE2997 conserved hypothetical protein Atu3583 [imported] - Agrobacterium tumefacien... KPTA_AGRFC - Probable RNA 2'-phosphotransferase OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN=kptA PE=3 SV...	1.0E-54	[12..199]	[3..175]
KPTA_FUSNN - Probable RNA 2'-phosphotransferase OS=Fusobacterium nucleatum subsp. nucleatum GN=kptA PE=3 SV=1 KPTA_FUSNN - Probable RNA 2'-phosphotransferase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / ...	9.0E-54	[11..199]	[4..178]
KPTA_CLOPE - Probable RNA 2'-phosphotransferase OS=Clostridium perfringens GN=kptA PE=3 SV=1 gi\|168213341, gi... - gi\|170715146\|gb\|EDT27328.1\| RNA 2'-phosphotransferase [Clostridium perfringens CPE str. F4969], gi\|1... KPTA_CLOPE - Probable RNA 2'-phosphotransferase OS=Clostridium perfringens (strain 13 / Type A) GN=kptA PE=3 SV=1	2.0E-53	[11..201]	[5..180]

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Predicted Domain #1

Region A:
Residues: [1-230]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRQVLQKDKR DVQLSKALSY LLRHTAVKEK LTIDSNGYTP LKELLSHNRL KTHKCTVDDI  60
   61 HRIVKENDKQ RFHIKTLGAD EEWICATQGH SIKSIQPSDE VLVPITEASQ LPQELIHGTN 120
  121 LQSVIKIIES GAISPMSRNH VHLSPGMLHA KGVISGMRSS SNVYIFIDCH SPLFFQTLKM 180
  181 FRSLNNVYLS SSIPVELIQK VVVKGNLKDE EKLDTLRRIL HERNIPLEKI

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	31.008774
Match:	PF01885
Description:	RNA 2'-phosphotransferase, Tpt1 / KptA family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
transferase activity, transferring pentosyl groups	3.32684164956045	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	3.05863250787371	bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity	2.37948308090148	bayes_pls_golite062009
binding	1.5526011325617	bayes_pls_golite062009
transferase activity	1.5222353301058	bayes_pls_golite062009
DNA binding	1.26521338734397	bayes_pls_golite062009
nucleic acid binding	1.22968208666588	bayes_pls_golite062009
catalytic activity	0.886617552734979	bayes_pls_golite062009
protein binding	0.847020402509418	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: