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View Structure Prediction Details

Protein: IZH2
Organism: Saccharomyces cerevisiae
Length: 327 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IZH2.

Description E-value Query
Range
Subject
Range
ADR1_MOUSE - Adiponectin receptor protein 1 OS=Mus musculus GN=Adipor1 PE=1 SV=1
5.0E-87 [16..318] [59..363]
paqr-1 - status:Partially_confirmed UniProt:Q94177 protein_id:AAB09107.2
5.0E-83 [16..317] [127..426]
gi|18377749 - gi|18377749|gb|AAL67024.1| unknown protein [Arabidopsis thaliana]
3.0E-68 [15..317] [1..350]
IZH1_YEAST - ADIPOR-like receptor IZH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IZH1 PE=1 SV=1
gi|207346210 - gi|207346210|gb|EDZ72775.1| YDR492Wp-like protein [Saccharomyces cerevisiae AWRI1631]
IZH1 - Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcript...
2.0E-67 [11..319] [1..312]
ADRL_SCHPO - ADIPOR-like receptor SPBC12C2.09c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC12C2...
SPBC12C2.09c - Haemolysin-III family protein
3.0E-67 [26..318] [27..316]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHVGEESFQ MSTLLERTKS VQELKKRAAG KTSANPAEVA KAKKVLRRLY SWDEIPEWQR  60
   61 DNDFILHGYV KE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.538 a.4.5 "Winged helix" DNA-binding domain
View Download 0.730 a.2.3 Chaperone J-domain
View Download 0.616 a.16.1 S15/NS1 RNA-binding domain
View Download 0.597 a.2.7 tRNA-binding arm
View Download 0.638 a.51.1 Cytochrome c oxidase subunit h
View Download 0.530 a.28.2 Colicin E immunity proteins
View Download 0.492 a.2.7 tRNA-binding arm
View Download 0.461 a.2.7 tRNA-binding arm
View Download 0.453 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.441 a.47.2 t-snare proteins
View Download 0.430 a.28.1 ACP-like
View Download 0.426 a.7.7 BAG domain
View Download 0.425 a.16.1 S15/NS1 RNA-binding domain
View Download 0.412 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.407 a.157.1 Skp1 dimerisation domain-like
View Download 0.396 a.16.1 S15/NS1 RNA-binding domain
View Download 0.383 a.17.1 p8-MTCP1
View Download 0.373 a.4.1 Homeodomain-like
View Download 0.372 a.51.1 Cytochrome c oxidase subunit h
View Download 0.370 a.2.7 tRNA-binding arm
View Download 0.368 a.2.7 tRNA-binding arm
View Download 0.363 f.17.1 F1F0 ATP synthase subunit C
View Download 0.355 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.353 a.51.1 Cytochrome c oxidase subunit h
View Download 0.350 a.16.1 S15/NS1 RNA-binding domain
View Download 0.348 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.343 a.2.3 Chaperone J-domain
View Download 0.337 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.336 a.2.7 tRNA-binding arm
View Download 0.323 a.16.1 S15/NS1 RNA-binding domain
View Download 0.319 a.2.7 tRNA-binding arm
View Download 0.315 a.4.1 Homeodomain-like
View Download 0.307 a.74.1 Cyclin-like
View Download 0.307 a.51.1 Cytochrome c oxidase subunit h
View Download 0.307 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.306 a.4.1 Homeodomain-like
View Download 0.303 a.28.1 ACP-like
View Download 0.302 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.291 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.283 a.126.1 Serum albumin-like
View Download 0.281 a.47.2 t-snare proteins
View Download 0.275 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.274 a.2.7 tRNA-binding arm
View Download 0.272 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.266 i.1.1 Ribosome and ribosomal fragments
View Download 0.265 a.7.7 BAG domain
View Download 0.265 a.7.7 BAG domain
View Download 0.262 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.255 a.16.1 S15/NS1 RNA-binding domain
View Download 0.255 f.15.1 Small-conductance potassium channel
View Download 0.252 i.1.1 Ribosome and ribosomal fragments
View Download 0.251 a.4.5 "Winged helix" DNA-binding domain
View Download 0.250 f.17.1 F1F0 ATP synthase subunit C
View Download 0.248 a.4.1 Homeodomain-like
View Download 0.248 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.244 a.28.2 Colicin E immunity proteins
View Download 0.244 a.118.1 ARM repeat
View Download 0.244 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.244 a.2.7 tRNA-binding arm
View Download 0.242 a.157.1 Skp1 dimerisation domain-like
View Download 0.238 a.161.1 beta-catenin-interacting protein ICAT
View Download 0.238 a.2.7 tRNA-binding arm
View Download 0.236 a.30.1 ROP protein
View Download 0.236 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.235 a.2.7 tRNA-binding arm
View Download 0.234 f.15.1 Small-conductance potassium channel
View Download 0.232 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.231 a.2.7 tRNA-binding arm
View Download 0.229 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.228 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.226 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.220 a.157.1 Skp1 dimerisation domain-like
View Download 0.216 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.216 a.16.1 S15/NS1 RNA-binding domain
View Download 0.210 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.206 i.1.1 Ribosome and ribosomal fragments
View Download 0.204 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.202 a.4.1 Homeodomain-like
View Download 0.200 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators

Predicted Domain #2
Region A:
Residues: [73-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSSFIETFKS LFYLHNESVN IYSHLIPALG FFTVLLLDKS TIKVFATTTW LDHMVIDLFY  60
   61 SGAFACLILS SSFHCLKSHS LRIATLGNKL DYLGICILIV TSMVSILYYG YFEKFSLFCL 120
  121 FALITVSFGI ACSIVSLKDK FRKREWRPYR AGLFVCFGLS SIIPIFSGLY CYSFSEIWTQ 180
  181 IQLFWVLLGG VLYIIGAVLY GMRFPEKICP GKFDIWGHSH QLFHFLVVIA ALCHLRGLLN 240
  241 SYELVHIKME NGIVS

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 126.39794
Match: PF03006
Description: Haemolysin-III related

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle