YRC Public Data Repository - Protein Structure Prediction

Protein:	BIO3
Organism:	Saccharomyces cerevisiae
Length:	480 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BIO3.

Description	E-value	Query Range	Subject Range
gi\|67772574, gi\|... - gi\|67772574\|dbj\|BAE00005.1\| biotin biosynthesis enzyme [Saccharomyces cerevisiae], gi\|1297327\|gb\|AAB...	0.0	[1..480]	[1..480]
gi\|6137239 - gi\|6137239\|gb\|AAF04396.1\|AF191556_4 BioA [Xenorhabdus nematophila]	0.0	[15..472]	[6..422]
BIOA_METJA - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase OS=Methanocaldococcus jannaschii GN=bioA ... gi\|1591938, gi\|1... - gi\|1591938\|gb\|AAB99307.1\| adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA) [Methano...	0.0	[1..475]	[1..463]
gi\|13366126 - gi\|13366126\|dbj\|BAB39453.1\| DAPA aminotransferase [Kurthia sp. 538-KA26]	0.0	[9..477]	[1..452]
BIOA_AQUAE - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase OS=Aquifex aeolicus GN=bioA PE=3 SV=1 BIOA_AQUAE - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase OS=Aquifex aeolicus (strain VF5) GN=bioA ...	0.0	[10..478]	[5..453]
gi\|205327724, gi... - gi\|205327724\|gb\|EDZ14488.1\| adenosylmethionine-8-amino-7-oxononanoate transaminase [Salmonella enter... BIOA_SALTY - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase OS=Salmonella typhimurium GN=bioA PE=3 SV... lcl\|NC_016856.1_... - [gene=bioA] [protein=adenosylmethionine-8-amino-7-oxononanoate aminotransferase] [protein_id=YP_0052... BIOA_SALTY - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase OS=Salmonella typhimurium GN=bioA PE=3 SV... BIOA_SALTY - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase OS=Salmonella typhimurium (strain LT2 / S...	0.0	[9..471]	[1..421]
BIOA_LYSSH - Adenosylmethionine-8-amino-7-oxononanoate aminotransferase OS=Lysinibacillus sphaericus GN=bioA PE=1...	0.0	[13..477]	[7..452]
gi\|255007201 - gi\|255007201\|ref\|ZP_05145802.2\| adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Staphylo... gi\|90583902, gi\|... - gi\|90583902\|ref\|ZP_01239651.1\| Adenosylmethionine--8-amino-7-oxononanoate aminotransferase [Staphylo... gi\|269204059\|ref... - adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Staphylococcus aureus subsp. aureus ED98... gi\|13702375, gi\|... - gi\|15928004\|ref\|NP_375537.1\| adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Staphylococ... gi\|90586443, gi\|... - gi\|90586443\|ref\|ZP_01242140.1\| Adenosylmethionine--8-amino-7-oxononanoate aminotransferase [Staphylo... gi\|25506622 - pir\|\|C90044 hypothetical protein bioA [imported] - Staphylococcus aureus (strain N315) gi\|15925416, gi\|... - gi\|15925416\|ref\|NP_372950.1\| adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Staphylococ... gi\|156980741, gi... - gi\|156980741\|ref\|YP_001443000.1\| adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Staphyl... gi\|253314763 - gi\|253314763\|ref\|ZP_04837976.1\| adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Staphylo...	0.0	[11..471]	[4..444]
gi\|213857245 - gi\|213857245\|ref\|ZP_03384216.1\| adenosylmethionine--8-amino-7-oxononanoate transaminase [Salmonella ... gi\|213647612 - gi\|213647612\|ref\|ZP_03377665.1\| adenosylmethionine--8-amino-7-oxononanoate transaminase [Salmonella ... gi\|214000509 - gi\|214000509\|ref\|ZP_03411244.1\| adenosylmethionine--8-amino-7-oxononanoate transaminase [Salmonella ... gi\|194401820, gi... - gi\|194443157\|ref\|YP_002040029.1\| adenosylmethionine-8-amino-7-oxononanoate transaminase [Salmonella ... gi\|25287261, gi\|... - gi\|25287261\|pir\|\|AG0596 adenosylmethionine-8-amino-7-oxononanoate aminotransferase [imported] - Salm... gi\|213424809 - gi\|213424809\|ref\|ZP_03357559.1\| adenosylmethionine--8-amino-7-oxononanoate transaminase [Salmonella ... gi\|213052119 - gi\|213052119\|ref\|ZP_03344997.1\| adenosylmethionine--8-amino-7-oxononanoate transaminase [Salmonella ... gi\|29138140, gi\|... - gi\|29142509\|ref\|NP_805851.1\| adenosylmethionine--8-amino-7-oxononanoate transaminase [Salmonella ent... gi\|16759718 - gi\|16759718\|ref\|NP_455335.1\| adenosylmethionine--8-amino-7-oxononanoate transaminase [Salmonella ent...	0.0	[9..471]	[1..421]

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Predicted Domain #1

Region A:
Residues: [1-480]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQEISYTPD VAELLDFDKK HIWHPYTSLS SPLNVYPVKS AHGCKLVLDT DSPVDVEVID  60
   61 AMSSWWCVIH GYNNPELNEA LTKQMLKFSH VLLGGFTHKG AVNLVQKLLK VIDEPSLQYC 120
  121 FLADSGSVAV EVALKMALQS NMSGEATKNR TKFLTIKNGY HGDTFGAMSV CDPENSMHHI 180
  181 YNDRLSENIF AQAPSIVDGL PTSQNGFEDH WNAEEVTDLK KQFELHSDKI CAVILEPILQ 240
  241 GAGGLRPYHP QFLIEVQKLC NQYDVLFIMD EIATGFGRTG EIFAFKHCQK YQDQHGISPS 300
  301 DQIKVVPDIL CVGKGLTSGY MTMSAVVVND KVASRISSPN SPTGGCFMHG PTFMGNALAC 360
  361 SVAEKSMDIL LRGEWRKQVS AIENQIYREL YQYIKNPDNG LIGTVVKRVS VIGAVGIVEL 420
  421 YKKTDPEWFQ KKFISKGVHI RPFNCLCYIM PPYVITTEEL TKVNQVLIEV LHEWKSHINQ 480
  481

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1256.0
Match:	1qj3A_
Description:	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, BioA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
4-aminobutyrate transaminase activity	3.63797881096751	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	3.359406422625	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
5-aminolevulinate synthase activity	1.85905571238884	bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity	1.74778109525713	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	1.63055151623667	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	1.63055151623667	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	1.4383564662931	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
transferase activity, transferring acyl groups	1.19150094103499	bayes_pls_golite062009
succinate-semialdehyde dehydrogenase binding	0.78144409237642	bayes_pls_golite062009
carbon-sulfur lyase activity	0.698312655247044	bayes_pls_golite062009
intramolecular transferase activity, transferring amino groups	0.659071155545801	bayes_pls_golite062009
N-succinyltransferase activity	0.52897097514616	bayes_pls_golite062009
binding	0.49769115245722	bayes_pls_golite062009
ornithine-oxo-acid transaminase activity	0.311107335626334	bayes_pls_golite062009
N-acyltransferase activity	0.2609065149092	bayes_pls_golite062009
nucleic acid binding	0.186646089509162	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
cystathionine beta-lyase activity	0.15938456446406	bayes_pls_golite062009
sulfurtransferase activity	0.0450490929307473	bayes_pls_golite062009
DNA binding	0.0281750086102144	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: