YRC Public Data Repository - Protein Structure Prediction

Protein:	NOG2
Organism:	Saccharomyces cerevisiae
Length:	486 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOG2.

Description	E-value	Query Range	Subject Range
NOG2_YEAST - Nucleolar GTP-binding protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NOG2 PE=... NOG2 - Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for...	0.0	[1..467]	[1..467]
NOG2_SCHPO - Nucleolar GTP-binding protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=nog2 PE=1 ... SPAC6F6.03c - ribosome export GTPase	0.0	[1..468]	[1..463]
NOG2_MOUSE - Nucleolar GTP-binding protein 2 OS=Mus musculus GN=Gnl2 PE=2 SV=1	2.0E-95	[26..478]	[29..472]
GNL2 - guanine nucleotide binding protein-like 2 (nucleolar)	8.0E-94	[26..472]	[29..466]
NOG2_PNECA - Nucleolar GTP-binding protein 2 OS=Pneumocystis carinii GN=NOG2 PE=2 SV=1	6.0E-93	[18..468]	[7..446]
NUG2_ARATH - Nuclear/nucleolar GTPase 2 OS=Arabidopsis thaliana GN=NUG2 PE=1 SV=1	2.0E-84	[31..472]	[33..465]
gi\|85014445, gi\|... - gi\|85014445\|ref\|XP_955718.1\| GTP-binding protein [Encephalitozoon cuniculi GB-M1], gi\|19171412\|emb\|C... gi\|19173286 - ref\|NP_597089.1\| similarity to HYPOTHETICAL GTP-BINDING PROTEIN YN8U_yeast [Encephalitozoon cuniculi...	2.0E-76	[27..474]	[10..417]
DER_CLOPE, ENGA_... - GTP-binding protein engA OS=Clostridium perfringens GN=engA PE=3 SV=1, GTPase Der OS=Clostridium per... DER_CLOP1 - GTPase Der OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 82... DER_CLOPS - GTPase Der OS=Clostridium perfringens (strain SM101 / Type A) GN=der PE=3 SV=1 gi\|168217042, gi... - gi\|182380862\|gb\|EDT78341.1\| putative GTP-binding protein Era [Clostridium perfringens NCTC 8239], gi... DER_CLOPE - GTPase Der OS=Clostridium perfringens (strain 13 / Type A) GN=der PE=3 SV=1 gi\|169299237, gi... - gi\|169342731\|ref\|ZP_02863772.1\| putative GTP-binding protein Era [Clostridium perfringens C str. JGS... gi\|177908885, gi... - gi\|182625851\|ref\|ZP_02953617.1\| putative GTP-binding protein Era [Clostridium perfringens D str. JGS... gi\|170661368, gi... - gi\|170661368\|gb\|EDT14051.1\| putative GTP-binding protein Era [Clostridium perfringens E str. JGS1987... gi\|170711316, gi... - gi\|170711316\|gb\|EDT23498.1\| putative GTP-binding protein Era [Clostridium perfringens B str. ATCC 36... gi\|170714259, gi... - gi\|170714259\|gb\|EDT26441.1\| putative GTP-binding protein Era [Clostridium perfringens CPE str. F4969...	4.0E-64	[144..458]	[6..341]

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Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTGKKEKSR RIREGDTKDG NLRVKGENFY RDSKRVKFLN MYTSGKEIRN KKGNLIRAAS  60
   61 FQDSTIPDAR VQPDRRWFGN TRVISQDALQ HFRSALGETQ KDTYQVLLRR NK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.285	0.143	nucleolus	a.29.2	Bromodomain
View	Download	0.576	0.021	ribosome assembly	a.7.6	Ribosomal protein S20
View	Download	0.576	N/A	N/A	a.7.6	Ribosomal protein S20
View	Download	0.351	N/A	N/A	c.103.1	Hypothetical protein MT938 (MTH938)
View	Download	0.351	N/A	N/A	c.103.1	Hypothetical protein MT938 (MTH938)
View	Download	0.285	N/A	N/A	a.29.2	Bromodomain

Predicted Domain #2

Region A:
Residues: [113-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPMSLLEEKD ADESPKARIL DTESYADAFG PKAQRKRPRL AASNLEDLVK ATNEDITKYE  60
   61 EKQVLDATLG LMGNQEDKEN GWTSAAKEAI FSKGQSKRIW NELYKVIDSS DVVIHVLDAR 120
  121 DPLGTRCKSV EEYMKKETPH KHLIYVLNKC DLVPTWVAAA WVKHLSKERP TLAFHASITN 180
  181 SFGKGSLIQL LRQFSQLHTD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.522879
Match:	1jah__
Description:	cH-p21 Ras protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [313-486]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKQISVGFIG YPNTGKSSII NTLRKKKVCQ VAPIPGETKV WQYITLMKRI FLIDCPGIVP  60
   61 PSSKDSEEDI LFRGVVRVEH VTHPEQYIPG VLKRCQVKHL ERTYEISGWK DATEFIEILA 120
  121 RKQGRLLKGG EPDESGVSKQ ILNDFNRGKI PWFVLPPEKE GEEKPKKKEV EKTA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.0
Match:	1egaA_
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits