YRC Public Data Repository - Protein Structure Prediction

Protein:	PEX6
Organism:	Saccharomyces cerevisiae
Length:	1030 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX6.

Description	E-value	Query Range	Subject Range
PEX6 - AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxis... PEX6_YEAST - Peroxisomal ATPase PEX6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEX6 PE=1 SV=1	0.0	[1..1030]	[1..1030]
CDC48_SOYBN - Cell division cycle protein 48 homolog OS=Glycine max GN=CDC48 PE=2 SV=1	0.0	[192..1030]	[4..770]
CD48D_ARATH - Cell division control protein 48 homolog D OS=Arabidopsis thaliana GN=CDC48D PE=1 SV=1	0.0	[190..1030]	[2..768]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[201..1030]	[45..802]
CDC48_CAPAN - Cell division cycle protein 48 homolog OS=Capsicum annuum GN=CAFP PE=2 SV=1	0.0	[190..1030]	[2..768]
PEX6_PICAN - Peroxisomal biogenesis factor 6 OS=Pichia angusta GN=PEX6 PE=1 SV=1 PEX6_PICAN - Peroxisomal biogenesis factor 6 OS=Pichia angusta GN=PEX6 PE=1 SV=1	0.0	[57..1029]	[75..1114]
TERA_XENLA - Transitional endoplasmic reticulum ATPase OS=Xenopus laevis GN=vcp PE=1 SV=2	0.0	[196..1030]	[3..765]

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Predicted Domain #1

Region A:
Residues: [1-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKASLTFSLS GIYAPCSISR DIYLEYGDKK AECLYGTIRL PQYGPGCTPG KIVHCVLDDS  60
   61 LPFCSIVVPS KLFGFMPTQP TMDFCYFEPI LDNVVPVLDS VTFLINEQLY SKLMDLPQEM 120
  121 QQIQFLHYKY NINSMETVVH SRDILTSGLC QILNCSPFPQ GLVDFTETQL ILVNDTEQKL 180
  181 SALKYANEDE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [191-305]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYALPKIGTN SALSIDLESL PCTISRDLLR PAPHINDDNS IYAFTDAETL LRLDVTSGSF  60
   61 ITVSNMGCVR LVKLFVLLLP NGFKKRTIYA PPKIIASFPD CSVVTISKSN IGHTD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	593.457575
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [306-437]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPIANQVFIS RVGGWLQSQK CFQNIILTTL KKFFSESKRI LCQNDLIPIA FDSSMADLNI  60
   61 AEENDESDDE DELGQYYKND SLVWFFVTSA ELDCFSKDNS HFIIDPNRTK LITTNITNRR 120
  121 PLPLSRSNLQ RY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	593.457575
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [438-618]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGFAETFYYD LHIFPYVRQL VNILETSFNC SQRGITLNAS VLLHSTTNNV GKATMVRFAS  60
   61 KYLGIHLLEI DCLSLTSNSR QLDSTSKIIG YIRAKCENVL PYASPAVIFL AHLDSILLDV 120
  121 NANQDPEAIK LQKSINFEMS KLLDDFTFKF PGTTFVGSVN NIDNVPSSFR SHMRFEILVP 180
  181 V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	593.457575
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [619-707]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSEAQRLRIF QWYLSSHELN RDVQQKVPVS YMDNISFSSL SSYSAGLTPL DIKSIVETAR  60
   61 MTATARFYQE SKKCGWLPQS ILITQEDLS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	593.457575
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [708-765]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KATSKARNEF SVSIGAPQIP NVTWDDIGGI DFVKGEILDT IDMPLKHPEL FTSGMKKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.522879
Match:	1iqpA_
Description:	Replication factor C
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [766-883]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGILFYGPPG TGKTLMAKAI ATNFSLNFFS VKGPELLNMY IGESEANVRR VFQKAREAKP  60
   61 CVIFFDEIDS VAPKRGNQGD SGGVMDRIVS QLLAELDGMS TDADGVFVIG ATNRPDLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.39794
Match:	1d2nA_
Description:	Hexamerization domain of N-ethylmalemide-sensitive fusion (NSF) protein
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [884-1030]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEALLRPGRF DKLLYLGIPD TDTKQLNILE ALTRKFVLDN DVKLIELAKL CPFNYTGADF  60
   61 YALCSDAMLN AMSRIARMVE KKVSQHNELT GENISTRRWF DKIATKEDTK VVVKMEDFLK 120
  121 AQEQLTPSVS RAELNHYEAV RANFEGA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.61
Match:	1lv7A
Description:	AAA domain of cell division protein FtsH
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits