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View Structure Prediction Details

Protein: POP1
Organism: Saccharomyces cerevisiae
Length: 875 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for POP1.

Description E-value Query
Range
Subject
Range
POP1_YEAST - Ribonucleases P/MRP protein subunit POP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
POP1 - Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursor...
0.0 [1..875] [1..875]
SPAC25B8.16 - RNase P and RNase MRP subunit
POPI_SCHPO - Ribonucleases P/MRP protein subunit pop1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=p...
0.0 [5..685] [1..589]
gi|498156 - gi|498156|dbj|BAA06543.1| KIAA0061 [Homo sapiens]
0.0 [370..788] [317..760]
gi|21312814, gi|... - gi|21312814|ref|NP_080616.1| processing of precursor 1 isoform 2 [Mus musculus], gi|12855337|dbj|BAB...
0.0 [370..788] [438..872]
gi|4972738 - gi|4972738|gb|AAD34764.1| unknown [Drosophila melanogaster]
3.0E-45 [229..382] [52..205]
CE24787 - status:Confirmed UniProt:Q11188 protein_id:AAB53831.2
4.0E-45 [227..695] [93..535]
gi|6473450 - gi|6473450|dbj|BAA87135.1| Hypothetical protein [Schizosaccharomyces pombe]
1.0E-12 [5..80] [4..64]

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Predicted Domain #1
Region A:
Residues: [1-125]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSLSRGNG GKKVLNKNQL LKRNRIRNAR SIRAEAVAAS STKTGTPSDL SESGSKLNVD  60
   61 QFISSRQFEV KQLQLAMHNS KAASSTRIFQ ALPRKLRRRT ASHNVRRIPK RMRNRALREM 120
  121 RKSDQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.409 0.232 ribonuclease P activity a.1.1 Globin-like
View Download 0.608 0.195 ribonuclease P activity a.133.1 Phospholipase A2, PLA2
View Download 0.500 0.056 ribonuclease P activity a.118.8 TPR-like
View Download 0.377 0.012 ribonuclease P activity a.24.4 Hemerythrin
View Download 0.509 0.008 ribonuclease P activity a.59.1 PAH2 domain
View Download 0.367 N/A N/A a.24.3 Cytochromes
View Download 0.366 N/A N/A a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.366 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.349 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.345 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.323 N/A N/A a.7.8 GAT domain
View Download 0.315 N/A N/A a.22.1 Histone-fold
View Download 0.287 N/A N/A a.29.2 Bromodomain
View Download 0.267 N/A N/A d.110.4 SNARE-like
View Download 0.236 N/A N/A a.63.1 Apolipophorin-III
View Download 0.221 N/A N/A a.74.1 Cyclin-like
View Download 0.213 N/A N/A a.24.14 FAT domain of focal adhesion kinase
View Download 0.208 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.208 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.203 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain

Predicted Domain #2
Region A:
Residues: [126-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDVLKGSSAS SRKAHGLNAK QLYKARMSIK LLRLASKSTS MKLSMPPEVT SSNCHVRQKI  60
   61 KTLKRMIKES STANPNIKLL NNRMGSYDCT GVNELAPIPK GRVKYTKRQK HFAWLPTHIW 120
  121 NAKRSHMMKR WGYQMVWAPT QKCFKLTHRL GGDTCSSDGA LCMDSSYIGT IIVKDKSNDS 180
  181 EGDFLKSIIG KLTAERANLR KYREGQVLFQ GLIYSFNEEN GEDSTKPL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
methyltransferase activity 1.83230066187063 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 1.757479064419 bayes_pls_golite062009
catalytic activity 1.52741791343033 bayes_pls_golite062009
binding 1.07222887529954 bayes_pls_golite062009
transferase activity 0.0529926681035639 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [354-800]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPCDVFWVQK DTAIIRLHPS IYTQVFNILL QHKEKLTVQD CRYSLASVTL KGAKALESLA  60
   61 SCLRSTEYSK SFEQFKMVSM ITDHNALPQR CTFAFEAIDP RHLAAPKKLN DSQRKTVNSD 120
  121 DILSLHENYP QDEINAVFNE LCDPESRTQS YNNQNTLKEI SARRYKLLTA TPNSINKTTV 180
  181 PFKESDDPSI PLVIIRRLKT RDWIVVLPWF WLLPLWHLLN RIPRMYHIGL RQFQQIQYEN 240
  241 KQLYFPDDYP FTQLGYIENS FYKKEASKTK WDRKPMGKRI NFEKIKDIHN TKLPAYSGEI 300
  301 GDFFSSDWRF LQILRNGIDY LQRNDKTLEL MDSKKTGQFN AQGVRDINCV NDVLEFCKDY 360
  361 EAKTKAMSLS IEENIPVALC KNRKCQFRTP DSISVNSSSF SLTFFPRCII AVSCTLLERG 420
  421 HPKDNARIYQ VPEKDLEHWL QLAKGVY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [801-875]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPNGRKDHDL KIPLPEVHDL IGFITSGTYH LNCGNGMGIG FIDHHAAIRQ PTRYVLIRNV  60
   61 GTNTYRLGEW SKISV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.678 d.58.3 Protease propeptides/inhibitors
View Download 0.626 a.28.1 ACP-like
View Download 0.542 d.95.2 Homing endonucleases
View Download 0.572 d.58.10 Acylphosphatase-like
View Download 0.714 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.530 d.58.24 CheY-binding domain of CheA
View Download 0.525 b.3.2 Carboxypeptidase D, a regulatory domain
View Download 0.513 d.58.17 Metal-binding domain
View Download 0.497 b.1.1 Immunoglobulin
View Download 0.467 d.58.1 4Fe-4S ferredoxins
View Download 0.465 d.58.49 YajQ-like
View Download 0.442 d.58.2 Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
View Download 0.408 d.58.4 Dimeric alpha+beta barrel
View Download 0.404 d.95.2 Homing endonucleases
View Download 0.400 b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.384 d.74.2 C-terminal domain of arginine repressor
View Download 0.384 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.382 d.141.1 Ribosomal protein L6
View Download 0.382 a.28.1 ACP-like
View Download 0.379 b.24.1 Hyaluronate lyase-like, C-terminal domain
View Download 0.372 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.365 b.1.1 Immunoglobulin
View Download 0.363 d.52.1 Alpha-lytic protease prodomain
View Download 0.361 d.58.48 MTH1187-like
View Download 0.359 d.58.5 GlnB-like
View Download 0.356 d.68.7 R3H domain
View Download 0.347 d.58.17 Metal-binding domain
View Download 0.338 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.337 c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.334 b.48.1 mu transposase, C-terminal domain
View Download 0.331 d.76.1 GYF domain
View Download 0.329 d.68.3 SirA-like
View Download 0.316 d.109.1 Actin depolymerizing proteins
View Download 0.312 d.12.1 Ribosomal proteins L23 and L15e
View Download 0.311 d.95.2 Homing endonucleases
View Download 0.310 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.292 d.58.48 MTH1187-like
View Download 0.291 b.1.2 Fibronectin type III
View Download 0.288 d.58.35 Pseudouridine synthase
View Download 0.284 a.4.5 "Winged helix" DNA-binding domain
View Download 0.282 d.58.5 GlnB-like
View Download 0.279 b.1.2 Fibronectin type III
View Download 0.278 d.58.1 4Fe-4S ferredoxins
View Download 0.275 d.58.3 Protease propeptides/inhibitors
View Download 0.272 b.122.1 PUA domain-like
View Download 0.270 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.269 b.7.4 Rab geranylgeranyltransferase alpha-subunit, insert domain
View Download 0.258 c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.252 a.4.5 "Winged helix" DNA-binding domain
View Download 0.245 b.1.18 E set domains
View Download 0.241 b.1.1 Immunoglobulin
View Download 0.240 d.15.7 Immunoglobulin-binding domains
View Download 0.226 c.51.3 B12-dependend dehydatases associated subunit
View Download 0.224 b.7.3 PHL pollen allergen
View Download 0.224 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.221 d.15.2 CAD & PB1 domains
View Download 0.220 g.10.1 Hairpin loop containing domain-like
View Download 0.216 b.36.1 PDZ domain-like
View Download 0.215 g.3.7 Scorpion toxin-like
View Download 0.209 d.131.1 DNA clamp
View Download 0.204 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle