YRC Public Data Repository - Protein Structure Prediction

Protein:	CHS1
Organism:	Saccharomyces cerevisiae
Length:	1131 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CHS1.

Description	E-value	Query Range	Subject Range
CHS1 - Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-ac...	0.0	[1..1131]	[1..1131]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[203..1126]	[9..916]
gi\|83774827, gi\|... - gi\|83774827\|dbj\|BAE64950.1\| unnamed protein product [Aspergillus oryzae], gi\|19071965\|dbj\|BAB85684.1... gi\|169783242 - gi\|169783242\|ref\|XP_001826083.1\| hypothetical protein [Aspergillus oryzae RIB40]	0.0	[191..1128]	[13..920]
gi\|9082308 - gi\|9082308\|gb\|AAF82801.1\|AF276826_1 class I chitin synthase [Coccidioides posadasii]	0.0	[163..1126]	[17..912]
CHS3_NEUCR - Chitin synthase 3 OS=Neurospora crassa GN=chs-3 PE=3 SV=2 CHS3_NEUCR - Chitin synthase 3 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGS...	0.0	[217..1128]	[2..888]
CHS2_EXODE - Chitin synthase 2 OS=Exophiala dermatitidis GN=CHS2 PE=3 SV=2	0.0	[172..1126]	[3..919]
gi\|6176510 - gi\|6176510\|gb\|AAF05595.1\|AF188934_1 chitin synthase [Blumeria graminis]	0.0	[361..1128]	[2..760]
gi\|19068022 - gi\|19068022\|gb\|AAL23717.1\| chitin synthase A [Glomerella graminicola]	0.0	[188..1128]	[2..899]
CHSA_AMPQU - Chitin synthase A OS=Ampelomyces quisqualis GN=CHSA PE=3 SV=1	0.0	[228..1126]	[2..900]

Back

Predicted Domain #1

Region A:
Residues: [1-142]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDQNNRSRN EYHSNRKNEP SYELQNAHSG LFHSSNEELT NRNQRYTNQN ASMGSFTPVQ  60
   61 SLQFPEQSQQ TNMLYNGDDG NNNTINDNER DIYGGFVNHH RQRPPPATAE YNDVFNTNSQ 120
  121 QLPSEHQYNN VPSYPLPSIN VI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2.69897
Match:	1deqA_
Description:	Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [143-409]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTTPELIHNG SQTMATPIER PFFNENDYYY NNRNSRTSPS IASSSDGYAD QEARPILEQP  60
   61 NNNMNSGNIP QYHDQPFGYN NGYHGLQAKD YYDDPEGGYI DQRGDDYQIN SYLGRNGEMV 120
  121 DPYDYENSLR HMTPMERREY LHDDSRPVND GKEELDSVKS GYSHRDLGEY DKDDFSRDDE 180
  181 YDDLNTIDKL QFQANGVPAS SSVSSIGSKE SDIIVSNDNL TANRALKRSG TEIRKFKLWN 240
  241 GNFVFDSPIS KTLLDQYATT TENANTL

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.32
Match:	1k83A
Description:	RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [410-488]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNEFKFMRYQ AVTCEPNQLA EKNFTVRQLK YLTPRETELM LVVTMYNEDH ILLGRTLKGI  60
   61 MDNVKYMVKK KNSSTWGPD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [489-565]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AWKKIVVCII SDGRSKINER SLALLSSLGC YQDGFAKDEI NEKKVAMHVY EHTTMINITN  60
   61 ISESEVSLEC NQGTVPI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [696-855]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGEIMENEGF HFFSSNMYLA EDRILCFEVV TKKNCNWILK YCRSSYASTD VPERVPEFIL  60
   61 QRRRWLNGSF FASVYSFCHF YRVWSSGHNI GRKLLLTVEF FYLFFNTLIS WFSLSSFFLF 120
  121 FRILTVSIAL AYHSAFNVLS VIFLWLYGIC TLSTFILSLG

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.7
Match:	1dioA
Description:	Diol dehydratase, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [566-695]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLLFCLKEQN QKKINSHRWA FEGFAELLRP NIVTLLDAGT MPGKDSIYQL WREFRNPNVG  60
   61 GACGEIRTDL GKRFVKLLNP LVASQNFEYK MSNILDKTTE SNFGFITVLP GAFSAYRFEA 120
  121 VRGQPLQKYF

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.7
Match:	1dioA
Description:	Diol dehydratase, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity, transferring hexosyl groups	2.23446625487311	bayes_pls_golite062009
UDP-glycosyltransferase activity	1.84596125277114	bayes_pls_golite062009
catalytic activity	1.73979371332125	bayes_pls_golite062009
transferase activity	1.18156663897445	bayes_pls_golite062009
acetylgalactosaminyltransferase activity	0.823843077041128	bayes_pls_golite062009
cytidylyltransferase activity	0.666765511953956	bayes_pls_golite062009
nucleotidyltransferase activity	0.641710647713692	bayes_pls_golite062009
binding	0.61043334112269	bayes_pls_golite062009
polypeptide N-acetylgalactosaminyltransferase activity	0.600389101620522	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	0.539883035270389	bayes_pls_golite062009
glucuronosyltransferase activity	0.510390802401046	bayes_pls_golite062009
mannosyltransferase activity	0.505948108814334	bayes_pls_golite062009
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	0.360354014290234	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.301396160525425	bayes_pls_golite062009
UDP-N-acetylglucosamine diphosphorylase activity	0.0309517682490415	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [856-908]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKPKSTEKFY VLTCVIFAVM MIYMIFCSIF MSVKSFQNIL KNDTISFEGL ITT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [909-1131]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAFRDIVISL GSTYCLYLIS SIIYLQPWHM LTSFIQYILL SPSYINVLNI YAFCNVHDLS  60
   61 WGTKGAMANP LGKINTTEDG TFKMEVLVSS SEIQANYDKY LKVLNDFDPK SESRPTEPSY 120
  121 DEKKTGYYAN VRSLVIIFWV ITNFIIVAVV LETGGIADYI AMKSISTDDT LETAKKAEIP 180
  181 LMTSKASIYF NVILWLVALS ALIRFIGCSI YMIVRFFKKV TFR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: