YRC Public Data Repository - Protein Structure Prediction

Protein:	FMP41
Organism:	Saccharomyces cerevisiae
Length:	259 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FMP41.

Description	E-value	Query Range	Subject Range
FMP41 - Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging ... gi\|151944369 - gi\|151944369\|gb\|EDN62647.1\| conserved protein [Saccharomyces cerevisiae YJM789] FMP41_YEAST - Uncharacterized mitochondrial hydrolase FMP41 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288... gi\|207341803 - gi\|207341803\|gb\|EDZ69755.1\| YNL168Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190409152 - gi\|190409152\|gb\|EDV12417.1\| hypothetical protein SCRG_03302 [Saccharomyces cerevisiae RM11-1a]	6.0E-75	[1..259]	[1..259]
YG56_METJA, Y165... - (Q59050) Hypothetical protein MJ1656, Uncharacterized protein MJ1656 OS=Methanocaldococcus jannaschi... Y1656_METJA - Uncharacterized protein MJ1656 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-...	2.0E-67	[9..244]	[37..234]
Y643_PYRHO - Uncharacterized protein PH0643 OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 /... Y643_PYRHO - Uncharacterized protein PH0643 OS=Pyrococcus horikoshii GN=PH0643 PE=3 SV=1	4.0E-67	[9..243]	[20..222]
YD97_PYRAB, Y139... - (Q9UYW0) Hypothetical protein PYRAB13970, Uncharacterized protein PYRAB13970 OS=Pyrococcus abyssi GN... Y1397_PYRAB - Uncharacterized protein PYRAB13970 OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=PYRAB13970 PE=3 SV=1	9.0E-67	[9..247]	[15..221]
gi\|14336767 - gi\|14336767\|gb\|AAK61295.1\|AE006639_9 similar to homoprotocatechuate catabolism bifunctional isomeras...	1.0E-65	[4..249]	[9..218]
gi\|18893073, gi\|... - gi\|18977388\|ref\|NP_578745.1\| 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [Pyrococcus furiosus DSM ...	1.0E-65	[9..243]	[17..219]
FAHD1_MOUSE - Acylpyruvase FAHD1, mitochondrial OS=Mus musculus GN=Fahd1 PE=1 SV=2	1.0E-65	[4..249]	[15..224]
gi\|15679504, gi\|... - gi\|2622625\|gb\|AAB85982.1\| 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [Methanothermobacter thermau... gi\|7448783 - pir\|\|A69068 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase - Methanobacterium thermoautotrophicum (st...	2.0E-64	[4..247]	[50..257]
gi\|58331823, gi\|... - gi\|58331823\|gb\|AAW70409.1\| At4g15940 [Arabidopsis thaliana], gi\|21593651\|gb\|AAM65618.1\| isomerase li...	4.0E-64	[1..254]	[5..222]

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Predicted Domain #1

Region A:
Residues: [1-259]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYNYLKAAR KIICIGRNYA AHIKELNNST PKQPFFFLKP TSSIVTPLSS SLVKTTRPAN  60
   61 STFNGLNEDG TNPGPIFIPR GVKVHHEIEL ALIVSKHLSN VTKMKPEEVY DSISGVALAL 120
  121 DLTARNVQDE AKKKGLPWTI SKGFDTFMPI SAIVSREKFS SYKSNLQDIF RVKCSVNGQL 180
  181 RQDGGTNLML HPLHKILQHI STMISLEPGD IILTGTPAGV GELKPGDRVH CELLQNNDNI 240
  241 VDMNFECENR PGPYEFRET

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	167.770868
Match:	1gttA_
Description:	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpcE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity, acting on acid carbon-carbon bonds	3.47506644461251	bayes_pls_golite062009
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	3.3661586952187	bayes_pls_golite062009
catalytic activity	1.43840931606572	bayes_pls_golite062009
binding	0.917289226788792	bayes_pls_golite062009
protein binding	0.334167038998597	bayes_pls_golite062009
hydrolase activity	0.145057589038159	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: