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View Structure Prediction Details

Protein: TEP1
Organism: Saccharomyces cerevisiae
Length: 434 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TEP1.

Description E-value Query
Range
Subject
Range
TEP1_YEAST - Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 OS=Saccharomyces cerevisiae (st...
TEP1 - Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is li...
0.0 [1..434] [1..434]
gi|9507011, gi|2... - gi|9507011|ref|NP_062013.1| protein tyrosine phosphatase, receptor type, S [Rattus norvegicus], gi|2...
3.0E-97 [1..334] [1308..1660]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-97 [1..334] [1308..1660]
gi|19743923, gi|... - gi|19743923|ref|NP_570924.1| protein tyrosine phosphatase, receptor type, sigma isoform 2 precursor ...
1.0E-96 [1..334] [1355..1707]
gi|440973 - gi|440973|gb|AAB28877.1| receptor protein tyrosine phosphatase-sigma, RPTP-sigma [rats, brain, Pepti...
1.0E-95 [1..334] [946..1298]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREEGSELEM EKGFLKWKPV NLMKKILSLP MKKTKNDIGL RLDISYILVN LIVCSYPVNT  60
   61 YPKLLYRNSL DDLILFLTVY HGKGNFRIFN FRGEKEDSDY KDNDLIGIAA KFESKDFEIQ 120
  121 ELRSTLINDG KIPISPIDLE TRTLVEEETN NVICERIG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [176-197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIENYLSVSK NRVAVLHCRM GK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 187.69897
Match: 1d5rA_
Description: Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [159-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WLDHFPPPFE LLEEIVD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [198-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRSGMITVAY LMKYLQCPLG EARLIFMQAR FKYGMTNGVT IPSQLRYLRY HEFFITHEKA  60
   61 AQEGISNEAV KFKFKFRLAK MTFLRPSSLI TSESAIVTTK IQHYNDDRNA LLTRKVVYSD 120
  121 IMAHECG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 187.69897
Match: 1d5rA_
Description: Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [325-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNMTFIFGRD YLTLENDCRI EFTLGTSKSK AASSIISWTS CASCWLNIYL ETLMHIIKDD  60
   61 SSPDYFQVER LKRDEMLGTT ISWQELDGFG ELSTHGLKLF QALKLEWEII 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle