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View Structure Prediction Details

Protein: TEP1
Organism: Saccharomyces cerevisiae
Length: 434 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TEP1.

Description E-value Query
Range
Subject
Range
TEP1_YEAST - Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1 OS=Saccharomyces cerevisiae (st...
TEP1 - Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is li...
0.0 [1..434] [1..434]
gi|9507011, gi|2... - gi|9507011|ref|NP_062013.1| protein tyrosine phosphatase, receptor type, S [Rattus norvegicus], gi|2...
3.0E-97 [1..334] [1308..1660]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-97 [1..334] [1308..1660]
gi|19743923, gi|... - gi|19743923|ref|NP_570924.1| protein tyrosine phosphatase, receptor type, sigma isoform 2 precursor ...
1.0E-96 [1..334] [1355..1707]
gi|440973 - gi|440973|gb|AAB28877.1| receptor protein tyrosine phosphatase-sigma, RPTP-sigma [rats, brain, Pepti...
1.0E-95 [1..334] [946..1298]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREEGSELEM EKGFLKWKPV NLMKKILSLP MKKTKNDIGL RLDISYILVN LIVCSYPVNT  60
   61 YPKLLYRNSL DDLILFLTVY HGKGNFRIFN FRGEKEDSDY KDNDLIGIAA KFESKDFEIQ 120
  121 ELRSTLINDG KIPISPIDLE TRTLVEEETN NVICERIG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [176-197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIENYLSVSK NRVAVLHCRM GK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 187.69897
Match: 1d5rA_
Description: Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [159-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WLDHFPPPFE LLEEIVD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [198-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRSGMITVAY LMKYLQCPLG EARLIFMQAR FKYGMTNGVT IPSQLRYLRY HEFFITHEKA  60
   61 AQEGISNEAV KFKFKFRLAK MTFLRPSSLI TSESAIVTTK IQHYNDDRNA LLTRKVVYSD 120
  121 IMAHECG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 187.69897
Match: 1d5rA_
Description: Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [325-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNMTFIFGRD YLTLENDCRI EFTLGTSKSK AASSIISWTS CASCWLNIYL ETLMHIIKDD  60
   61 SSPDYFQVER LKRDEMLGTT ISWQELDGFG ELSTHGLKLF QALKLEWEII 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.455 a.7.1 Spectrin repeat
View Download 0.495 a.7.8 GAT domain
View Download 0.640 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.582 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.557 a.118.11 Cytochrome c oxidase subunit E
View Download 0.435 a.47.2 t-snare proteins
View Download 0.408 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.401 a.133.1 Phospholipase A2, PLA2
View Download 0.396 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.378 d.19.1 MHC antigen-recognition domain
View Download 0.373 a.74.1 Cyclin-like
View Download 0.369 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.356 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.339 a.3.1 Cytochrome c
View Download 0.326 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.323 a.22.1 Histone-fold
View Download 0.321 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.320 a.7.6 Ribosomal protein S20
View Download 0.305 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.304 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.304 a.3.1 Cytochrome c
View Download 0.301 a.48.2 Transferrin receptor ectodomain, C-terminal domain
View Download 0.294 a.51.1 Cytochrome c oxidase subunit h
View Download 0.279 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.267 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.265 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.265 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.265 d.92.2 beta-N-acetylhexosaminidase-like domain
View Download 0.263 a.26.1 4-helical cytokines
View Download 0.257 b.40.4 Nucleic acid-binding proteins
View Download 0.252 f.17.2 Cytochrome c oxidase subunit II-like, transmembrane region
View Download 0.248 d.19.1 MHC antigen-recognition domain
View Download 0.242 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.236 c.47.2 RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View Download 0.227 a.23.2 Diol dehydratase, gamma subunit
View Download 0.226 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.222 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.217 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.215 a.168.1 GEF domain of SopE toxin
View Download 0.214 a.46.1 Methionine synthase domain
View Download 0.213 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.212 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.210 f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.206 a.4.1 Homeodomain-like
View Download 0.206 a.118.9 ENTH/VHS domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle