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View Structure Prediction Details

Protein: TOP2
Organism: Saccharomyces cerevisiae
Length: 1428 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOP2.

Description E-value Query
Range		 Subject
Range
TOP2_YEAST - DNA topoisomerase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TOP2 PE=1 SV=2
TOP2 - Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the pho...
 0.0 [1..1428] [1..1428]
gi|18369822 - gi|18369822|dbj|BAB84106.1| DNA topoisomerase II [Talaromyces flavus var. flavus]
 0.0 [9..1127] [1..1094]
TOP2_CANAX - DNA topoisomerase 2 OS=Candida albicans GN=TOP2 PE=3 SV=1
 0.0 [4..1397] [54..1430]
gi|3786306 - gi|3786306|dbj|BAA33955.1| TopoisomeraseII [Candida glabrata]
 0.0 [3..1404] [2..1382]
TOP2_PEA - DNA topoisomerase 2 OS=Pisum sativum GN=TOP2 PE=2 SV=1
 0.0 [5..1346] [16..1319]
gi|9632132, gi|2... - gi|9632132|ref|NP_048939.1| hypothetical protein PBCV1_A583L [Paramecium bursaria Chlorella virus 1]...
 0.0 [10..1116] [2..1061]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [3..1413] [15..1414]
TOP2_CRIFA - DNA topoisomerase 2 OS=Crithidia fasciculata GN=TOP2 PE=3 SV=1
 0.0 [6..1267] [1..1214]
gi|2909393 - gi|2909393|emb|CAA76313.1| DNA topoisomerase II alpha [Cricetulus longicaudatus]
 0.0 [2..1418] [23..1441]
gi|4929497 - gi|4929497|gb|AAD34021.1|AF150876_1 DNA topoisomerase II [Leishmania donovani]
 0.0 [6..1272] [1..1217]

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Predicted Domain #1
Region A:
Residues: [1-248] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEPVSASD KYQKISQLEH ILKRPDTYIG SVETQEQLQW IYDEETDCMI EKNVTIVPGL  60
   61 FKIFDEILVN AADNKVRDPS MKRIDVNIHA EEHTIEVKND GKGIPIEIHN KENIYIPEMI 120
  121 FGHLLTSSNY DDDEKKVTGG RNGYGAKLCN IFSTEFILET ADLNVGQKYV QKWENNMSIC 180
  181 HPPKITSYKK GPSYTKVTFK PDLTRFGMKE LDNDILGVMR RRVYDINGSV RDINVYLNGK 240
  241 SLKIRNFK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 302.218487
Match: 1ei1A_
Description: DNA gyrase B
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [249-405] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYVELYLKSL EKKRQLDNGE DGAAKSDIPT ILYERINNRW EVAFAVSDIS FQQISFVNSI  60
   61 ATTMGGTHVN YITDQIVKKI SEILKKKKKK SVKSFQIKNN MFIFINCLIE NPAFTSQTKE 120
  121 QLTTRVKDFG SRCEIPLEYI NKIMKTDLAT RMFEIAD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 302.218487
Match: 1ei1A_
Description: DNA gyrase B
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [406-561] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANEENALKKS DGTRKSRITN YPKLEDANKA GTKEGYKCTL VLTEGDSALS LAVAGLAVVG  60
   61 RDYYGCYPLR GKMLNVREAS ADQILKNAEI QAIKKIMGLQ HRKKYEDTKS LRYGHLMIMT 120
  121 DQDHDGSHIK GLIINFLESS FPGLLDIQGF LLEFIT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [604-656] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLGTSLAQEV REYFSNLDRH LKIFHSLQGN DKDYIDLAFS KKKADDRKEW LRQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1bgw__
Description: DNA topoisomerase II, C-terminal fragment (residues 410-1202)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [562-603] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIIKVSITKP TKNTIAFYNM PDYEKWREEE SHKFTWKQKY YK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [657-701] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEPGTVLDPT LKEIPISDFI NKELILFSLA DNIRSIPNVL DGFKP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [792-803] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKIFHPADDP LY

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [816-879] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EWYLPILPMI LVNGAEGIGT GWSTYIPPFN PLEIIKNIRH LMNDEELEQM HPWFRGWTGT  60
   61 IEEI

[Run NCBI BLAST on this sequence.]

Region E:
Residues: [970-1012] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISLMNMVAFD PHGKIKKYNS VNEILSEFYY VRLEYYQKRK DHM

[Run NCBI BLAST on this sequence.]

Region F:
Residues: [1147-1165] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKLSAKDIWN TDLKAFEVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1bgw__
Description: DNA topoisomerase II, C-terminal fragment (residues 410-1202)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [702-791] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GQRKVLYGCF KKNLKSELKV AQLAPYVSEC TAYHHGEQSL AQTIIGLAQN FVGSNNIYLL  60
   61 LPNGAFGTRA TGGKDAAAAR YIYTELNKLT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [804-815] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYIQEDEKTV EP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [880-969] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPLRYRMYGR IEQIGDNVLE ITELPARTWT STIKEYLLLG LSGNDKIKPW IKDMEEQHDD  60
   61 NIKFIITLSP EEMAKTRKIG FYERFKLISP

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [1013-1146] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SERLQWEVEK YSFQVKFIKM IIEKELTVTN KPRNAIIQEL ENLGFPRFNK EGKPYYGSPN  60
   61 DEIAEQINDV KGATSDEEDE ESSHEDTENV INGPEELYGT YEYLLGMRIW SLTKERYQKL 120
  121 LKQKQEKETE LENL

[Run NCBI BLAST on this sequence.]

Region E:
Residues: [1166-1207] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQEFLQRDAE ARGGNVPNKG SKTKGKGKRK LVDDEDYDPS KK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1bgw__
Description: DNA topoisomerase II, C-terminal fragment (residues 410-1202)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1208-1428] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKKSTARKGK KIKLEDKNFE RILLEQKLVT KSKAPTKIKK EKTPSVSETK TEEEENAPSS  60
   61 TSSSSIFDIK KEDKDEGELS KISNKFKKIS TIFDKMGSTS ATSKENTPEQ DDVATKKNQT 120
  121 TAKKTAVKPK LAKKPVRKQQ KVVELSGESD LEILDSYTDR EDSNKDEDDA IPQRSRRQRS 180
  181 SRAASVPKKS YVETLELSDD SFIEDDEEEN QGSDVSFNEE D

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle