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View Structure Prediction Details

Protein: COX5A
Organism: Saccharomyces cerevisiae
Length: 153 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COX5A.

Description E-value Query
Range		 Subject
Range
COX41_RAT - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Rattus norvegicus GN=Cox4i1 PE=1 SV=1
 5.0E-48 [9..148] [3..157]
gi|123992973, gi... - gi|61357719|gb|AAX41434.1| cytochrome c oxidase subunit IV isoform 1 [synthetic construct], gi|12399...
COX4I1 - cytochrome c oxidase subunit IV isoform 1
gi|114663969, gi... - gi|114663971|ref|XP_511235.2| PREDICTED: similar to Cytochrome c oxidase subunit 4 isoform 1, mitoch...
 5.0E-48 [9..148] [3..157]
gi|190409043 - gi|190409043|gb|EDV12308.1| cytochrome c oxidase subunit Va [Saccharomyces cerevisiae RM11-1a]
COX5A_YEAST - Cytochrome c oxidase polypeptide 5A, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
COX5A - Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane...
gi|151944480 - gi|151944480|gb|EDN62758.1| cytochrome c oxidase subunit Va [Saccharomyces cerevisiae YJM789]
 5.0E-48 [1..153] [1..153]
COX41_MOUSE - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Mus musculus GN=Cox4i1 PE=1 SV=2
 2.0E-47 [9..148] [3..157]
COX41_BOVIN - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Bos taurus GN=COX4I1 PE=1 SV=1
 4.0E-47 [9..148] [3..157]
COX41_RABIT - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Oryctolagus cuniculus GN=COX4I1 PE=2 SV=1
 5.0E-46 [10..148] [4..157]
gi|7161891 - gi|7161891|emb|CAB76570.1| cytochrome c oxidase subunit V [Podospora anserina]
 8.0E-46 [2..148] [5..151]
COX5_NEUCR - Cytochrome c oxidase polypeptide 5, mitochondrial OS=Neurospora crassa GN=cya-4 PE=3 SV=2
COX5_NEUCR - Cytochrome c oxidase polypeptide 5, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-...
 5.0E-45 [1..148] [10..154]

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Predicted Domain #1
Region A:
Residues: [1-103] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRNTFTRAG GLSRITSVRF AQTHALSNAA VMDLQSRWEN MPSTEQQDIV SKLSERQKLP  60
   61 WAQLTEPEKQ AVWYISYGEW GPRRPVLNKG DSSFIAKGVA AGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.522879
Match: 1occD_
Description: Mitochondrial cytochrome c oxidase subunit IV
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytochrome-c oxidase activity 12.8672436325695 bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors 12.8672436325695 bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor 12.8672436325695 bayes_pls_golite062009
heme-copper terminal oxidase activity 12.5536631591417 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 6.39367011108548 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 6.23942388461757 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 5.62960572959435 bayes_pls_golite062009
oxidoreductase activity 5.40847023303734 bayes_pls_golite062009
cation transmembrane transporter activity 5.36812403817205 bayes_pls_golite062009
ion transmembrane transporter activity 5.16334360779969 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.74071132470389 bayes_pls_golite062009
substrate-specific transporter activity 4.53098112436118 bayes_pls_golite062009
binding 1.89752801758092 bayes_pls_golite062009
protein binding 1.46604940289928 bayes_pls_golite062009
catalytic activity 0.600497727931764 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [104-153] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFSVGLFAVV RMAGGQDAKT MNKEWQLKSD EYLKSKNANP WGGYSQVQSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.522879
Match: 1occD_
Description: Mitochondrial cytochrome c oxidase subunit IV
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle