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View Structure Prediction Details

Protein: YMR259C
Organism: Saccharomyces cerevisiae
Length: 1420 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YMR259C.

Description E-value Query
Range
Subject
Range
gi|732937 - gi|732937|emb|CAA88586.1| unknown [Saccharomyces cerevisiae]
0.0 [73..1420] [1..1348]
YQK7_SCHPO - Uncharacterized protein C1494.07 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC1494....
SPCC1494.07 - conserved eukaryotic protein
0.0 [114..992] [102..1036]
gi|11358244, gi|... - gi|7019649|emb|CAB75750.1| putative protein [Arabidopsis thaliana], gi|15233196|ref|NP_191076.1| unk...
0.0 [117..985] [413..1452]
gi|85014449, gi|... - gi|85014449|ref|XP_955720.1| hypothetical protein ECU09_1670 [Encephalitozoon cuniculi GB-M1], gi|19...
gi|19173288 - ref|NP_597091.1| hypothetical protein [Encephalitozoon cuniculi]
0.0 [313..856] [153..672]
gi|10437960 - gi|10437960|dbj|BAB15133.1| unnamed protein product [Homo sapiens]
0.0 [596..1028] [257..665]

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Predicted Domain #1
Region A:
Residues: [1-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTDVQFSSQ EIELFRVKEF LIANNPAKIN NENKDAVLTQ IEHDFRYLIQ YIKDGLPNLN  60
   61 ESTRLIFPDT FSICLLRSHQ IIASKKIDSQ EFLSAVKEQL LTEANANIIF EYVLDFWADG 120
  121 GAPLMNALRD LFSKLLNLLK ITYPMSTLKD VLFNWMNEIL EV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [163-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSTLRVQYYL IDALSSDFDL YYIIEKKPHF IDNSFSLMNS DLLANSVGKC IVSLLLNIYE  60
   61 KHFKKNESFV QEWIQLWKSC ALKYIHDKQY TKSINLYIMI PLFKNMPNSA FTLFLECMSN 120
  121 KDPSLLLSLL KIGQELGIEE EP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.465 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.718 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.347 c.78.2 Aspartate/glutamate racemase
View Download 0.347 a.72.1 Functional domain of the splicing factor Prp18
View Download 0.718 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.567 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.465 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.347 c.78.2 Aspartate/glutamate racemase
View Download 0.347 a.72.1 Functional domain of the splicing factor Prp18
View Download 0.346 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.311 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.281 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.278 a.26.1 4-helical cytokines
View Download 0.273 a.149.1 RNase III endonuclease catalytic domain
View Download 0.269 a.40.1 Calponin-homology domain, CH-domain
View Download 0.267 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.264 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.260 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.252 a.182.1 GatB/YqeY domain
View Download 0.249 d.162.1 LDH C-terminal domain-like
View Download 0.245 a.24.9 alpha-catenin/vinculin
View Download 0.244 a.129.1 GroEL equatorial domain-like
View Download 0.238 a.118.1 ARM repeat
View Download 0.235 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.234 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.233 d.90.1 NADH oxidase/flavin reductase
View Download 0.229 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.229 a.118.8 TPR-like
View Download 0.222 c.16.1 Lumazine synthase
View Download 0.213 d.44.1 Fe,Mn superoxide dismutase (SOD), C-terminal domain
View Download 0.207 a.63.1 Apolipophorin-III
View Download 0.207 d.13.1 HIT-like
View Download 0.204 a.118.8 TPR-like
View Download 0.201 d.86.1 Translation initiation factor eIF4e

Predicted Domain #3
Region A:
Residues: [305-889]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FCDNKYTTVD SVNKLIEQDE YKLQVFEILT FSTKKSKPIR PFVFKTIKQY LYVFFVDTEL  60
   61 ERRNYFCSSM KHFIFRTRDC AYSLARDARK LKKAEKFPDE QREKLAQVEE ARAFLVWLCN 120
  121 FIKYNLAPGT LYQANVTSLK LMHILIKSGV DKSTPQKFLD NQNKREYPFS IPILQDVTFL 180
  181 RLLIDLLVSN YADVRELSKE MLFIMISADE SRGLFLDTLD ANALKWTATS LLSDYEKGDA 240
  241 GATVYEFIFT VMGSQRSFID QTIDILAQMV QNLQNDSIGC AENSIGPHFA ALSLILNKFN 300
  301 SEENHQDTSK IISKLINLVL KSWEATRNVV CHDSAHGILP EKYANCGVPD QVIISHAFRA 360
  361 IKEASYLLET ILKKYPLTRD QLDSIGDLFI VQLSTIRHSG AFQAVLPGLK AFCIRCQLEF 420
  421 PAILEELLSK SVKSLKSKTQ HITRRSGGLP FLVTTVLSAE VTKGRPLLQK TFENLLLVAR 480
  481 LPIPPHQDEF DLPQVNAINC INAIFVEPKL SVHCTSFVSE ALELALLNFD CDIWALRNCS 540
  541 IMLFTSLQNR IFGKVGRSVS AKLFFTKYSG LRQLLLNILN SSIAQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [890-1031]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSGSERKSYQ IESIFLVLNV LLRLRPTAGY TGLKEFNVSV YECLSNENWK IRDMASRVLH  60
   61 MLSENFEEEI RKLLDLASIA KQNQLHGHLL ALQQLVPQYL SGTRDMELIQ RILEKKRMLL 120
  121 LENKCFITKK AYLKLTCCIL ET

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.649 0.568 cytoplasm a.1.1 Globin-like
View Download 0.739 0.141 cytoplasm a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.718 0.136 cytoplasm a.118.8 TPR-like
View Download 0.660 0.018 cytoplasm e.22.1 Dehydroquinate synthase-like
View Download 0.570 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.566 N/A N/A a.24.3 Cytochromes
View Download 0.546 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.540 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.533 N/A N/A a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.507 N/A N/A a.118.1 ARM repeat
View Download 0.477 N/A N/A a.126.1 Serum albumin-like
View Download 0.469 N/A N/A a.79.1 Antitermination factor NusB
View Download 0.457 N/A N/A a.85.1 Hemocyanin, N-terminal domain
View Download 0.456 N/A N/A a.118.8 TPR-like
View Download 0.452 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.444 N/A N/A d.95.2 Homing endonucleases
View Download 0.444 N/A N/A a.25.1 Ferritin-like
View Download 0.422 N/A N/A a.26.1 4-helical cytokines
View Download 0.417 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.415 N/A N/A d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.412 N/A N/A a.25.1 Ferritin-like
View Download 0.409 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.398 N/A N/A a.7.7 BAG domain
View Download 0.385 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.381 N/A N/A a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.378 N/A N/A a.1.1 Globin-like
View Download 0.377 N/A N/A a.72.1 Functional domain of the splicing factor Prp18
View Download 0.377 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.373 N/A N/A a.1.1 Globin-like
View Download 0.357 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.353 N/A N/A b.82.2 Clavaminate synthase-like
View Download 0.349 N/A N/A a.146.1 Telomeric repeat binding factor (TRF) dimerisation domain
View Download 0.326 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.323 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.323 N/A N/A a.74.1 Cyclin-like
View Download 0.314 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.297 N/A N/A a.47.2 t-snare proteins
View Download 0.293 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.289 N/A N/A a.118.1 ARM repeat
View Download 0.286 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.286 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.285 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.283 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.283 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.283 N/A N/A a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.281 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.280 N/A N/A a.26.1 4-helical cytokines
View Download 0.280 N/A N/A d.134.1 Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View Download 0.278 N/A N/A f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.276 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.267 N/A N/A a.74.1 Cyclin-like
View Download 0.265 N/A N/A a.26.1 4-helical cytokines
View Download 0.263 N/A N/A a.23.3 Methane monooxygenase hydrolase, gamma subunit
View Download 0.260 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.257 N/A N/A a.99.1 Cryptochrome/photolyase FAD-binding domain
View Download 0.253 N/A N/A f.1.1 Colicin
View Download 0.252 N/A N/A a.4.3 ARID-like
View Download 0.250 N/A N/A a.24.4 Hemerythrin
View Download 0.249 N/A N/A a.47.2 t-snare proteins
View Download 0.249 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.247 N/A N/A a.11.2 Second domain of FERM
View Download 0.245 N/A N/A a.24.3 Cytochromes
View Download 0.244 N/A N/A f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.242 N/A N/A a.47.2 t-snare proteins
View Download 0.239 N/A N/A a.1.1 Globin-like
View Download 0.234 N/A N/A a.19.1 Fertilization protein
View Download 0.233 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.229 N/A N/A a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.227 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.227 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.224 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.224 N/A N/A a.24.3 Cytochromes
View Download 0.223 N/A N/A a.1.1 Globin-like
View Download 0.221 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.219 N/A N/A a.26.1 4-helical cytokines
View Download 0.217 N/A N/A a.22.1 Histone-fold
View Download 0.213 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.211 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.206 N/A N/A c.95.1 Thiolase-like
View Download 0.204 N/A N/A e.34.1 NSP3 homodimer

Predicted Domain #5
Region A:
Residues: [1032-1420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CDIPDSILKD YISTLRNTFI AENNEYVVDG SKQLYLAQIL DMLLKYEDSI YLDDICLLGL  60
   61 YSPFYEAQLS TLQYMNTNFH WETTRNSEFL EQLQLLLRVP DLLPMAKALV VKILSRKKNT 120
  121 LSLTTCTDLL KTNNSEDTKL AAVSSLSAKL SSQTFHQVWN LLQGFFADSC SKDFRLASLE 180
  181 CLTAYPESCK NSRILLQLYN FLWDDDSEIR EKASFYLNKN FIQTADWEYN RNTSVTALIF 240
  241 TKKFVDVFTS SEVVEELCLQ LFQYLNEYDM FAAEESAKNC LFTIEKDNQF INELQKAMHI 300
  301 LNMIKLTGRD ISKCYKDQIH HLKSALLEHF NTEDFKDSPL GWCSNAEIFS RITLLKELIQ 360
  361 HYSPSDYENF INVLTKHSVH PLIISYSQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.68714838468719 bayes_pls_golite062009
protein binding 1.3800948965226 bayes_pls_golite062009
RNA binding 0.538045152794259 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1256-1420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADWEYNRNTS VTALIFTKKF VDVFTSSEVV EELCLQLFQY LNEYDMFAAE ESAKNCLFTI  60
   61 EKDNQFINEL QKAMHILNMI KLTGRDISKC YKDQIHHLKS ALLEHFNTED FKDSPLGWCS 120
  121 NAEIFSRITL LKELIQHYSP SDYENFINVL TKHSVHPLII SYSQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle