YRC Public Data Repository - Protein Structure Prediction

Protein:	FSH2
Organism:	Saccharomyces cerevisiae
Length:	223 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FSH2.

Description	E-value	Query Range	Subject Range
FSH2 - Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1... FSH2_YEAST - Family of serine hydrolases 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FSH2 PE=1 ...	3.0E-64	[1..223]	[1..223]
gi\|157169860 - gi\|157169860\|gb\|AAI52881.1\| Candidate tumor suppressor in ovarian cancer 2 [synthetic construct] OVCA2_MOUSE - Esterase OVCA2 OS=Mus musculus GN=Ovca2 PE=1 SV=1	2.0E-53	[2..221]	[6..222]
dfr1 - dihydrofolate reductase Dfr1 DYR_SCHPO - Dihydrofolate reductase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dfr1 PE=2 SV=2	2.0E-53	[3..219]	[5..219]
STR6_ARATH - Rhodanese-like domain-containing protein 6 OS=Arabidopsis thaliana GN=STR6 PE=2 SV=1	2.0E-53	[3..221]	[354..579]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-52	[3..219]	[5..219]
OVCA2 - ovarian tumor suppressor candidate 2 gi\|254071455, gi... - gi\|254071455\|gb\|ACT64487.1\| candidate tumor suppressor in ovarian cancer 2 protein [synthetic constr...	7.0E-44	[3..221]	[7..224]

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Predicted Domain #1

Region A:
Residues: [1-223]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKNVLMLHG LAQSGDYFAS KTKGFRAEME KLGYKLYYPT APNEFPPADV PDFLGEVIAD  60
   61 APGDGENTGV LAWLENDPST GGYFIPQTTI DYLHNYVLEN GPFAGIVGFS QGAGVAGYLA 120
  121 TDFNGLLGLT TEEQPPLEFF MAVSGFRFQP QQYQEQYDLH PISVPSLHVQ GELDTITEPA 180
  181 KVQGLYNSCT EDSRTLLMHS GGHFVPNSRG FVRKVAQWLQ QLT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.522879
Match:	1fj2A_
Description:	Acyl protein thioesterase 1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits