YRC Public Data Repository - Protein Structure Prediction

Protein:	GYL1
Organism:	Saccharomyces cerevisiae
Length:	720 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GYL1.

Description	E-value	Query Range	Subject Range
GYL1_YEAST - Probable GTPase-activating protein GYL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=... GYL1 - Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gy...	0.0	[1..720]	[1..720]
gi\|208965608 - gi\|208965608\|dbj\|BAG72818.1\| TBC1 domain family, member 4 [synthetic construct] gi\|23822237, gi\|... - gi\|7662198\|ref\|NP_055647.1\| TBC1 domain family, member 4 [Homo sapiens], pir\|\|T00261 hypothetical pr...	7.0E-78	[15..667]	[619..1280]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-71	[51..683]	[510..1155]
gi\|9790251, gi\|9... - gi\|988221\|gb\|AAA85223.1\| Tbc1, gi\|9790251\|ref\|NP_062610.1\| TBC1 domain family, member 1 [Mus musculu...	4.0E-67	[21..644]	[488..1095]
SPAC4G8.04 - GTPase activating protein YAD4_SCHPO - TBC domain-containing protein C4G8.04 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC...	3.0E-66	[13..538]	[195..760]

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Predicted Domain #1

Region A:
Residues: [1-247]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSNEDIHEE RIEVPRTPHQ TQPEKDSDRI ALRDEISVPE GDEKAYSDEK VEMATTNASS  60
   61 NFGSNESAKD GESIGAFSNP HEALMQSKLR EESQSKTILP SDDLSQQLET EESKVEEALK 120
  121 RITSPPLPPR ADCIEESASA LKSSLPPVLA GNKNDQAPLD RPQLPPRQVV NAETLHLKAP 180
  181 HGNATPSKSP TSAVGNSSSS TPPTLPPRRI EDPLDLAAQK HFLASTFKRN MLFYKSEDNS 240
  241 IKCDLDK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.35
Match:	1llwA
Description:	Alpha subunit of glutamate synthase, C-terminal domain; Alpha subunit of glutamate synthase, central and FMN domains; Alpha subunit of glutamate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [248-357]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NILNLKEDSK KINNNEIPEE VSSFWLKVIG DYQNILINDI ETLHFQLSRG IPAAYRLVVW  60
   61 QLVSYAKSKS FDPIYETYLT EMAPFDVQEF ENQLKMMDEV PSEYVKRISN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.045757
Match:	1fkmA_
Description:	Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [358-720]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLKAYLLFDP ECEFSTDIAY IINMILDVCE EEANAFGLLV RLMKVYGLRL LFLPSASEID  60
   61 ILCYKFDRLV EEFYPEIHNH MVEKGVRSSM FLPGFFTTLF QKKLPTEIQP RIGDMVFLEG 120
  121 IDSIMRILAT LLSNSRDHLL KMGFDDMLEL LKSGLLDAYI KQNDGTRGDT LLSNECMDKL 180
  181 LQDSMMKVAI TPKTMKKYSS EYEEIHRLDN EKEVQYKSIT EKNLHLQKHV RKLENDYTSL 240
  241 NREHVTIANE LVKNRLNIES VLNENNGYKL QILDLKKKLD SEKKKQVLGV YVPNDLKKDL 300
  301 EETMKKNTQV MDENLKLQDR ISELERLIEE IKTANKNGTL FEYSNSKNNP LGAGWSGFKK 360
  361 VFK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.69897
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [367-720]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PECEFSTDIA YIINMILDVC EEEANAFGLL VRLMKVYGLR LLFLPSASEI DILCYKFDRL  60
   61 VEEFYPEIHN HMVEKGVRSS MFLPGFFTTL FQKKLPTEIQ PRIGDMVFLE GIDSIMRILA 120
  121 TLLSNSRDHL LKMGFDDMLE LLKSGLLDAY IKQNDGTRGD TLLSNECMDK LLQDSMMKVA 180
  181 ITPKTMKKYS SEYEEIHRLD NEKEVQYKSI TEKNLHLQKH VRKLENDYTS LNREHVTIAN 240
  241 ELVKNRLNIE SVLNENNGYK LQILDLKKKL DSEKKKQVLG VYVPNDLKKD LEETMKKNTQ 300
  301 VMDENLKLQD RISELERLIE EIKTANKNGT LFEYSNSKNN PLGAGWSGFK KVFK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.154902
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits