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View Structure Prediction Details

Protein: YMR185W
Organism: Saccharomyces cerevisiae
Length: 981 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YMR185W.

Description E-value Query
Range
Subject
Range
YMR185W - Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elo...
RTP1_YEAST - RNA polymerase II assembly factor RTP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=R...
0.0 [1..981] [1..981]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [448..936] [318..816]
gi|16416012 - gi|16416012|emb|CAD01123.1| conserved hypothetical protein [Neurospora crassa]
0.0 [448..936] [313..811]
gi|16769274 - gi|16769274|gb|AAL28856.1| LD22423p [Drosophila melanogaster]
0.0 [538..934] [388..744]
SPBC20F10.08c - conserved eukaryotic protein
RTP1_SCHPO - RNA polymerase II assembly factor rtp1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rtp...
2.0E-81 [608..975] [422..735]
gi|12698037 - gi|12698037|dbj|BAB21837.1| KIAA1746 protein [Homo sapiens]
1.0E-60 [730..934] [841..1031]

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Predicted Domain #1
Region A:
Residues: [1-152]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEDKEQKIN IHDILNTRPK LTKKTALDVF FEDLDDNVIT PINEYVLDSG SSSSSSIYQA  60
   61 LKCSNNNEFV AVLLQKFQNL HIHVLEQQRR LIESKSDLLP ISLHDMKYVD ELINLLIIHG 120
  121 IDANLSPTMK IPFDSKRINT FKKGQKSAEY ET

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [153-368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRWHTINNDT LSQVITVFYN VLTSERSSDY LREIISKGSA YANILLGLIV LHLQLPNRYS  60
   61 SQMITNLEDT QETYTLFGVY TLLVETIQDE KVREPILSKL TTLTLRRPEN GLISLIDFVL 120
  121 GVRDAEDIDI EKFNRIYQIL MSKPKTMTNL QYLTELFKQI YDGLTFVNRP ILVTCLNGLI 180
  181 LKFYLRNKRI VNDFLFKKVR SIIFNSPLTD HTAKEL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.4666436207573 bayes_pls_golite062009
protein binding 1.12452075263773 bayes_pls_golite062009
nucleic acid binding 0.410251595672781 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [369-563]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDVINVLISL SKNSSSDLLN DLVTSCPDED GTTPGQFFLY VWIYALFLKK NQKLDPLEIN  60
   61 KLSISDNKST DSIHFPEQSS SKYYEVVLSL LKSLIVITEN FQYLNVLSLN LLNFEHEKWK 120
  121 YLIDLDTQLP YISVKNTDMA ELFFEKGSKN SQISEFLQDM DLSIELFMEF LVLLNDEEQS 180
  181 KTLFLDILKR WVHHT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [564-659]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKSEKRSSDN HSGMPSVTDN ALILMDLKLL ECMNNRFKTK IVNKPKDVLI VIDQLIDVVQ  60
   61 EKDETIQEVE ADSDDEVEEG EETEELDPNE NSSYKI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [660-777]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILQLLSTVLS ESSSSILLQN SYILKSISRK LQSFNTNASE IDALLASIDN ILINGHTTER  60
   61 NDNIEIEMDE ERLDKAITSL HDPLVPIKSY GLTELRHLAE KKSPVISLEK VLQIHLDY

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [778-981]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKNMDPFIYL NVIKGLTTLC ELEPETILPL LAEFYANKKK KNRLDDVLKV GEVFINYIQR  60
   61 QNELFQGKLA YLIIDTCLSI VRPNDSKPLD NRWRMSSMSI LGMCLQINAR GVSDRIRDML 120
  121 DCVFGILQLE QPQNHLKDKD DSFLMRRSAV HLIHDLLYST GFDLLPFEYN YDKLKTLLSY 180
  181 VRDQDEDYMV CEQIDKLLTV LDSL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.5
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle