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View Structure Prediction Details

Protein: ERB1
Organism: Saccharomyces cerevisiae
Length: 807 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERB1.

Description E-value Query
Range
Subject
Range
gi|38197040 - gi|38197040|gb|AAH05160.2| BOP1 protein [Homo sapiens]
661.0 [0..108] [806..28]
gi|15215181 - gi|15215181|gb|AAH12693.1| Block of proliferation 1 [Mus musculus]
653.0 [0..11] [806..13]

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Predicted Domain #1
Region A:
Residues: [1-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMAKNNKTTE AKMSKKRAAS EESDVEEDED KLLSVDGLID AEASESDEDD DEYESAVEEK  60
   61 ESSSDKEAQD DSDDDSDAEL NKLLAEEEGD GEEDYDSSEF SDDTTSLTDR LSGVKLQTIV 120
  121 DPNIYSKYAD GSDRIIKPEI NPVYDSDDSD AETQNTIGNI PLSAYDEMPH IGYDINGKRI 180
  181 MRPAKGSALD QLLDSIELPE GWTGLLDKNS GSSLNLTKEE LELISKIQRN EQTDDSINPY 240
  241 EPLIDWFTRH EEVMPLTAVP EPKRRFVPSK NEAKRVMKIV RAIREGRIIP PKKLKEMKEK 300
  301 EKIENYQY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [309-368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLWGDSTETN DHVMHLRAPK LPPPTNEESY NPPEEYLLSP EEKEAWENTE YSERERNFIP  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [369-751]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKYSALRKVP GYGESIRERF ERSLDLYLAP RVRKNKLNID PNSLIPELPS PKDLRPFPIR  60
   61 CSTIYAGHKG KVRTLSIDPS GLWLATGSDD GTVRVWEILT GREVYRTTLI DDEENPDYHI 120
  121 ECIEWNPDAN NGILAVAVGE NIHLIVPPIF GYDIENNGKT KIEDGFGYDT FGTVKKSNLE 180
  181 VNENGDGDED GENESAKNAV KKQVAQWNKP SQKQLEKDIC ITISCKKTVK KLSWHRKGDY 240
  241 FVTVQPDSGN TSVLIHQVSK HLTQSPFKKS KGIIMDAKFH PFKPQLFVCS QRYVRIYDLS 300
  301 QQILVKKLLP GARWLSKIDI HPRGDNLIAS SFDKRVLWHD LDLASTPYKT LRYHEKAVRS 360
  361 VNFHKKLPLF SSAADDGTIH VFH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.69897
Match: 1gg2B
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [752-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATVYDDMMKN PMIVPLKKLT GHKVINSLGV LDAIWHPREA WLFSAGADNT ARLWTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.69897
Match: 1erjA
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle