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View Structure Prediction Details

Protein: MIH1
Organism: Saccharomyces cerevisiae
Length: 554 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MIH1.

Description E-value Query
Range
Subject
Range
gi|602325, gi|101164 - gi|602325|gb|AAA57223.1| MIH1, pir||A32386 protein-tyrosine-phosphatase (EC 3.1.3.48) cdc25 homolog ...
540.0 [0..1] [474..1]
MPI1B_XENLA - M-phase inducer phosphatase 1-B OS=Xenopus laevis GN=cdc25-1-b PE=2 SV=1
358.0 [0..50] [415..188]
MPIP3_PIG - M-phase inducer phosphatase 3 OS=Sus scrofa GN=CDC25C PE=3 SV=1
gi|543093 - pir||S43123 protein-tyrosine-phosphatase (EC 3.1.3.48) cdc25 homolog - pig
356.0 [0..46] [414..131]
gi|114601943 - gi|114601943|ref|XP_001170975.1| PREDICTED: cell division cycle 25C protein isoform 1 [Pan troglodyt...
341.0 [0..81] [414..81]
gi|190691881, gi... - gi|190691881|gb|ACE87715.1| cell division cycle 25 homolog C (S. pombe) protein [synthetic construct...
CDC25C - cell division cycle 25 homolog C (S. pombe)
335.0 [0..81] [414..129]

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Predicted Domain #1
Region A:
Residues: [1-66]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNIFHGTED ECANEDVLSF QKISLKSPFG KKKNIFRNVQ TFFKSKSKHS NVDDDLINKE  60
   61 NLAFDK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.802 a.4.1 Homeodomain-like

Predicted Domain #2
Region A:
Residues: [67-176]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLLTNHRSK EIDGPSPNIK QLGHRDELDE NENENDDIVL SMHFASQTLQ SPTRNSSRRS  60
   61 LTNNRDNDLL SRIKYPGSPQ RSSSFSRSRS LSRKPSMNSS SNSSRRVQRQ 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [177-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGKIPRSSRK SSQKFSNITQ NTLNFTSASS SPLAPNSVGV KCFESCLAKT QIPYYYDDRN  60
   61 SNDFFPRISP ETLKNILQNN MCESFYNSCR IIDCRFEYEY TGGHIINSVN IHSRDELEYE 120
  121 FIHKVLHSDT SNNNTLPTLL IIHCEFSSHR GPSLASHLRN CDRIINQDHY PKLFYPDILI 180
  181 LDGGYKAVFD NFPELCYPRQ YVGMNSQENL LNCEQEMDKF RRESKRFATK NNSFRKLASP 240
  241 SNPNFFYRDS HQSSTTMASS ALSFRFEPPP KLSLNHRRVS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 279.54902
Match: 1cwrA
Description: CDC25b
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [457-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSSLNSSES TGDENFFPIL SKSSMSSNSN LSTSHMLLMD GLDTPSYFSF EDERGNHQQV  60
   61 SGDEEQDGDF TFVGSDREDL PRPARRSLFP SLETEDKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle