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View Structure Prediction Details

Protein: CDC5
Organism: Saccharomyces cerevisiae
Length: 705 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC5.

Description E-value Query
Range
Subject
Range
CDC5 - Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and ...
gi|151946161 - gi|151946161|gb|EDN64392.1| serine/threonine protein kinase [Saccharomyces cerevisiae YJM789]
CDC5_YEAST - Cell cycle serine/threonine-protein kinase CDC5/MSD2 OS=Saccharomyces cerevisiae (strain ATCC 204508...
0.0 [1..705] [1..705]
PLK3_RAT - Serine/threonine-protein kinase PLK3 (Fragment) OS=Rattus norvegicus GN=Plk3 PE=2 SV=1
0.0 [56..678] [1..598]
gi|15530236 - gi|15530236|gb|AAH13899.1| Polo-like kinase 3 (Drosophila) [Homo sapiens]
0.0 [35..678] [9..628]
gi|833810 - gi|833810|gb|AAC52191.1| putative serine/threonine kinase
0.0 [47..678] [1..591]
CDPKH_ARATH - Calcium-dependent protein kinase 17 OS=Arabidopsis thaliana GN=CPK17 PE=2 SV=1
0.0 [1..518] [1..514]
gi|218195438 - gi|218195438|gb|EEC77865.1| hypothetical protein OsI_17131 [Oryza sativa Indica Group]
gi|38344274, gi|... - gi|38344274|emb|CAE03753.2| OSJNBa0013K16.2 [Oryza sativa (japonica cultivar-group)], gi|215692742|d...
0.0 [1..541] [1..546]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [60..542] [5..486]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLGPLKAIN DKQLNTRSKL VHTPIKGNTA DLVGKENHFK QTKRLDPNND HHHQPAQKKK  60
   61 REKLSALCKT PP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [125-144]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLLSEIQIHK SMSHPNIVQF 

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [160-368]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ICPNGSLMEL LKRRKVLTEP EVRFFTTQIC GAIKYMHSRR VIHRDLKLGN IFFDSNYNLK  60
   61 IGDFGLAAVL ANESERKYTI CGTPNYIAPE VLMGKHSGHS FEVDIWSLGV MLYALLIGKP 120
  121 PFQARDVNTI YERIKCRDFS FPRDKPISDE GKILIRDILS LDPIERPSLT EIMDYVWFRG 180
  181 TFPPSIPSTV MSEAPNFEDI PEEQSLVNF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 486.0
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [73-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLIKTRGKDY HRGHFLGEGG FARCFQIKDD SGEIFAAKTV AKASIKSEKT RK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [145-159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDCFEDDSNV YILLE

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [369-382]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDCMEKSLLL ESMS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 486.0
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [383-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDKIQRQKRD YISSIKSSID KLEEYHQNRP FLPHSLSPGG TKQKYKEVVD IEAQRRLNDL  60
   61 AREARIRRAQ QAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 1ahr__
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [456-519]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRKELIATST NVIKSEISLR ILASECHLTL NGIVEAEAQY KMGGLPKSRL PKIKHPMIVT  60
   61 KWVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 1ahr__
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [520-602]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSNKHGFSYQ LSTEDIGVLF NNGTTVLRLA DAEEFWYISY DDREGWVASH YLLSEKPREL  60
   61 SRHLEVVDFF AKYMKANLSR VST

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.38
Match: 1mbyA
Description: Sak kinase Polo domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [603-705]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGREEYHKDD VFLRRYTRYK PFVMFELSDG TFQFNFKDHH KMAISDGGKL VTYISPSHES  60
   61 TTYPLVEVLK YGEIPGYPES NFREKLTLIK EGLKQKSTIV TVD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle