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View Structure Prediction Details

Protein: ERO1
Organism: Saccharomyces cerevisiae
Length: 563 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERO1.

Description E-value Query
Range
Subject
Range
gi|190408118 - gi|190408118|gb|EDV11383.1| endoplasmic oxidoreductin 1 precursor [Saccharomyces cerevisiae RM11-1a]
ERO1_YEAST - Endoplasmic oxidoreductin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERO1 PE=1 SV...
ERO1 - Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
0.0 [1..563] [1..563]
ero12 - ER oxidoreductin Ero1b
gi|19075813 - gi|19075813|ref|NP_588313.1| hypothetical protein SPCC1450.14c [Schizosaccharomyces pombe 972h-]
0.0 [39..524] [39..535]
ERO1A_RAT - ERO1-like protein alpha OS=Rattus norvegicus GN=Ero1a PE=1 SV=1
0.0 [23..421] [20..461]
ERO1L - ERO1-like (S. cerevisiae)
gi|254071493, gi... - gi|254071495|gb|ACT64507.1| ERO1-like (S. cerevisiae) protein [synthetic construct], gi|254071493|gb...
0.0 [23..423] [20..467]
ER1A_MOUSE, ERO1... - ERO1-like protein alpha OS=Mus musculus GN=Ero1l PE=2 SV=1, (Q8R180) ERO1-like protein alpha precurs...
0.0 [37..421] [34..461]
ERO1_ARATH - Endoplasmic reticulum oxidoreductin-1 OS=Arabidopsis thaliana GN=AERO1 PE=1 SV=1
0.0 [3..422] [22..442]

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Predicted Domain #1
Region A:
Residues: [1-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLRTAIATL CLTAFTSATS NNSYIATDQT QNAFNDTHFC KVDRNDHVSP SCNVTFNELN  60
   61 AINENIRDDL SALLKSDFFK YFRLDLYKQC SFWDANDGLC LNRACSVDVV EDWDTLPEYW 120
  121 QPEILGSFNN DTMKEADDSD DECKFLDQLC QTSKKPVDIE DTINYCDVND FNG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on sulfur group of donors 3.04541306149882 bayes_pls_golite062009
thiol oxidase activity 1.56067935587779 bayes_pls_golite062009
binding 1.51315006963036 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor 1.31287436426921 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.25764823859811 bayes_pls_golite062009
unfolded protein binding 1.21113889423637 bayes_pls_golite062009
catalytic activity 1.09506175640279 bayes_pls_golite062009
protein binding 0.524855475418758 bayes_pls_golite062009
disulfide oxidoreductase activity 0.384901602591813 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [174-563]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNAVLIDLTA NPERFTGYGG KQAGQIWSTI YQDNCFTIGE TGESLAKDAF YRLVSGFHAS  60
   61 IGTHLSKEYL NTKTGKWEPN LDLFMARIGN FPDRVTNMYF NYAVVAKALW KIQPYLPEFS 120
  121 FCDLVNKEIK NKMDNVISQL DTKIFNEDLV FANDLSLTLK DEFRSRFKNV TKIMDCVQCD 180
  181 RCRLWGKIQT TGYATALKIL FEINDADEFT KQHIVGKLTK YELIALLQTF GRLSESIESV 240
  241 NMFEKMYGKR LNGSENRLSS FFQNNFFNIL KEAGKSIRYT IENINSTKEG KKKTNNSQSH 300
  301 VFDDLKMPKA EIVPRPSNGT VNKWKKAWNT EVNNVLEAFR FIYRSYLDLP RNIWELSLMK 360
  361 VYKFWNKFIG VADYVSEETR EPISYKLDIQ 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.07
Match: 1n1bA
Description: (+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle