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View Structure Prediction Details

Protein: TCB3
Organism: Saccharomyces cerevisiae
Length: 1545 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TCB3.

Description E-value Query
Range		 Subject
Range
TCB3_YEAST - Tricalbin-3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TCB3 PE=1 SV=1
TCB3 - Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected...
 0.0 [1..1545] [1..1545]
gi|6687541 - gi|6687541|emb|CAB65007.1| transmembrane protein [Erysiphe pisi]
 0.0 [56..1535] [4..1442]
YKH3_SCHPO - Uncharacterized protein PYUK71.03c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAPYUK...
SPAPYUK71.03c - C2 domain protein
 0.0 [66..1323] [2..1223]
ESYT1_MOUSE - Extended synaptotagmin-1 OS=Mus musculus GN=Esyt1 PE=1 SV=2
 0.0 [215..1240] [52..1087]
gi|190691873, gi... - gi|190691873|gb|ACE87711.1| family with sequence similarity 62 (C2 domain containing), member A prot...
ESYT1 - extended synaptotagmin-like protein 1
 0.0 [215..1075] [62..870]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [215..1075] [20..838]
gi|3170547 - gi|3170547|gb|AAC34394.1| unknown [Takifugu rubripes]
 0.0 [215..1093] [42..957]

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Predicted Domain #1
Region A:
Residues: [1-360] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGIKAQVHP PPDSTLFHEE EKKKVGGNLP QKVINQQERG SDHAPSGHHQ YHQLINHDAN  60
   61 DTKTSNSVSD VSKGQKTADS NPEGKKQSSK DIFVASSAQK TNQLPGPNPQ GSIGAVPLEG 120
  121 LRPKEFRSAP SRKPNKFDTS ITKPGVLDDL GKLDEKDIKE KFHLDSDDKL FPWQNVGEFH 180
  181 ASGKGSPNTK MSRVIKAYIL ENFYNDWYCN IATVLGTCFF SWLFAYIGFS WWSMIFIFLG 240
  241 TATVYNAEYT RFNRNIRDDL KRVTVEETLS DRVESTTWLN SFLSKFWVIY MPVLSQQVKD 300
  301 NVNPQLAGVA PGYGIDALAI DEFTLGSKAP TIKGIKSYTK TGKNTVEMDW SFAFTPSDVS 360
  361

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [361-481] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMTATEAREK INPKISLGVT LGKSFVSKTM PILVEDINVA GKMRIKVEFG KAFPNIKIVS  60
   61 LQLLEPPLID FALKPIGGDT LGLDVMSFLP GLKSFVKNII NSNIGPMLFP PNHLDINVED 120
  121 I

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.816 0.032 cellular bud b.61.1 Avidin/streptavidin

Predicted Domain #3
Region A:
Residues: [482-633] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAQSKEAIG VLAVTIASAD SLKGSDFITN TVDPYIVMTT EDAVPGTDEE VRTSIKSNVK  60
   61 NPRWNETKYL LLNTLEQKLN LKCFDFNDVR KDTVIGDLQL DLADLLQNPV LDNQTAELRS 120
  121 GTKSKGILHY SLHWFPVKED KSEEKAVERA EA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.502279
Match: 1rsy__
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [634-769] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAKGKKEDEN EDTTEKEEDE NEESSQTDVG IAKITLQKVK YLDTTSSMTG SLSPCAELFI  60
   61 DGQKVKSYRT LRRINEPSWN ETIEVLVPSK SNSKFVLKIF DDRMNGKALI CEYSSSLDDI 120
  121 MTTLDTAQEF VKGSPQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.485 0.921 cellular bud d.110.1 Profilin (actin-binding protein)

Predicted functions:

Term Confidence Notes
binding 0.966987533854771 bayes_pls_golite062009
protein binding 0.13127988530671 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [770-915] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDIYLDVSWK SIEMTGAFAA ANSVSEPIGC IKLDVKDAII KGDLSGVGDV DPYYTVSLNR  60
   61 RVLYKSIYHS DTDHPIFDNS TYVPIFSPNQ ILTLEFHDYQ KIGKDRFIGS VQIPTSNVFK 120
  121 KDPKSGKYVG NNGKEEISKL KLKDHE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.9897
Match: 1dsyA_
Description: C2 domain from protein kinase c (alpha)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.966987533854771 bayes_pls_golite062009
protein binding 0.13127988530671 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [916-979] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKVTESIVNV STTFIPINLV YSPEELVNVE KLEKELKEKK KKFEATQEEN EQEMEKNPKE  60
   61 WEVA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 0.966987533854771 bayes_pls_golite062009
protein binding 0.13127988530671 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [980-1116] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EIEDPFDSDE KKINRKAKLS LNELIKQKSG ILSMQILEGT LSPSSAYLEI LADDISYPVF  60
   61 ICMKPSQGKL NSEMANIFIR DLNYSKLHFR VSKKHIAKDS DDVISETSYS TLKLLKQAYE 120
  121 EPMWLNFNGS KMKVRFL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 149.503332
Match: 1dqvA_
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1117-1286] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTPTSVKLPS SESVEDTGYL NIKLISGHGL KSADRNGYSD PFVHIFVNDK KVFKSNIKKK  60
   61 TLDPVWNEDA KIPILSRSKN QVIFNVLDWD RAGDNDDLGQ ASLDVSSLEV GKTYNWNLNL 120
  121 NTQGSIKLQG SFNPEYIKPS FDIVKGGITD KPMKIASGAA HATVGIAGTG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 149.503332
Match: 1dqvA_
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1287-1402] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGAATGVATG GLKKGGHLLK SLGGNPMKRS KSSNGNESNG AKKSSEKKSF DRRSPSNLNS  60
   61 TSVTPRASLD YDPSVPNTSY APVQSASPVV KPTDNTSSSS NKKDTPSSNS RGHSRA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1403-1545] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSFARTLAPH GTYNGFITVV AAENVAKHVQ IKISLTQGGR LKHIYKTKSQ KANNDGVAVF  60
   61 DEECSFKASP EANLVLGAIS HQRLSRDKDL GIAQINLGDP QIQQDGQISV KLGDGHLIVK 120
  121 INYGKDKNGQ VPPVPEVPQE YTQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.358 0.928 cellular bud d.110.1 Profilin (actin-binding protein)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle