YRC Public Data Repository - Protein Structure Prediction

Protein:	STE23
Organism:	Saccharomyces cerevisiae
Length:	988 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STE23.

Description	E-value	Query Range	Subject Range
IDE1_ARATH - Insulin-degrading enzyme-like 1, peroxisomal OS=Arabidopsis thaliana GN=PXM16 PE=2 SV=1	0.0	[54..980]	[5..938]
IDE - insulin-degrading enzyme	0.0	[24..966]	[15..957]
IDE_MOUSE - Insulin-degrading enzyme OS=Mus musculus GN=Ide PE=1 SV=1	0.0	[25..966]	[16..957]
IDE_RAT - Insulin-degrading enzyme OS=Rattus norvegicus GN=Ide PE=1 SV=1	0.0	[24..966]	[15..957]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[63..986]	[16..969]
gi\|15485612 - gi\|15485612\|emb\|CAC67408.1\| insulin degrading enzyme [Solanum lycopersicum]	0.0	[61..986]	[11..946]
gi\|279568, gi\|124156 - pir\|\|SNFFIN insulysin (EC 3.4.24.56) - fruit fly (Drosophila melanogaster), sp\|P22817\|IDE_DROME Ins...	0.0	[42..978]	[7..945]
IPI:IPI00285619.... - Ensembl_locations(Chr-bp):5-155070384 Splice isoform 2 of P47245, Tax_Id=10116 Splice Isoform 2 of N... gi\|2462659 - gi\|2462659\|emb\|CAA63696.1\| NRD2 convertase [Rattus sp.]	0.0	[92..981]	[286..1180]

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Predicted Domain #1

Region A:
Residues: [1-69]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVSLLASSS AFVTKPLLTQ LVHLSPISLN FTVRRFKPFT CLSRYYTTNP YNMTSNFKTF  60
   61 NLDFLKPDL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [70-204]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DERSYRFIEL PNKLKALLIQ DPKADKAAAS LDVNIGAFED PKNLPGLAHF CEHLLFMGSE  60
   61 KFPDENEYSS YLSKHGGSSN AYTASQNTNY FFEVNHQHLF GALDRFSGFF SCPLFNKDST 120
  121 DKEINAVNSE NKKNL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [223-302]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPYHKFSTGN IETLGTLPKE NGLNVRDELL KFHKNFYSAN LMKLCILGRE DLDTLSDWTY  60
   61 DLFKDVANNG REVPLYAEPI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [435-460]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQAGSPSSTV SSLAKCLEKD YIPVSR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	155.37734
Match:	1hr6B_
Description:	Mitochondrial processing peptidase (MPP) beta chain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [205-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNDIWRIYQL DKSLTNTK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [303-434]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPEHLQKII QVRPVKDLKK LEISFTVPDM EEHWESKPPR ILSHLIGHEG SGSLLAHLKK  60
   61 LGWANELSAG GHTVSKGNAF FAVDIDLTDN GLTHYRDVIV LIFQYIEMLK NSLPQKWIFN 120
  121 ELQDISNATF KF

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [461-554]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILAMGLLTKY EPDLLTQYTD ALVPENSRVT LISRSLETDS AEKWYGTAYK VVDYPADLIK  60
   61 NMKSPGLNPA LTLPRPNEFV STNFKVDKID GIKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	155.37734
Match:	1hr6B_
Description:	Mitochondrial processing peptidase (MPP) beta chain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [555-988]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDEPVLLLSD DVSKLWYKKD DRFWQPRGYI YLSFKLPHTH ASIINSMLST LYTQLANDAL  60
   61 KDVQYDAACA DLRISFNKTN QGLAITASGF NEKLIILLTR FLQGVNSFEP KKDRFEILKD 120
  121 KTIRHLKNLL YEVPYSQMSN YYNAIINERS WSTAEKLQVF EKLTFEQLIN FIPTIYEGVY 180
  181 FETLIHGNIK HEEALEVDSL IKSLIPNNIH NLQVSNNRLR SYLLPKGKTF RYETALKDSQ 240
  241 NVNSCIQHVT QLDVYSEDLS ALSGLFAQLI HEPCFDTLRT KEQLGYVVFS SSLNNHGTAN 300
  301 IRILIQSEHT TPYLEWRINN FYETFGQVLR DMPEEDFEKH KEALCNSLLQ KFKNMAEESA 360
  361 RYTAAIYLGD YNFTHRQKKA KLVANITKQQ MIDFYENYIM SENASKLILH LKSQVETKSS 420
  421 MKMNWTPLSI QLAS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits