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View Structure Prediction Details

Protein: VPS38
Organism: Saccharomyces cerevisiae
Length: 439 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS38.

Description E-value Query
Range
Subject
Range
VPS38 - Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) so...
VPS38_YEAST - Vacuolar protein sorting-associated protein 38 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
0.0 [1..439] [1..439]

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Predicted Domain #1
Region A:
Residues: [1-128]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRFLLSRRQ RHLRMICFHN ISLFRANGDS KLIKEYGDGF IPCFFILESI RGELLYVSEV  60
   61 QSGSLRKLSF QELPKLTGAS TMIVLKLVGL VPSDILCTIS SDKNGIIDDK WCVLCTYTID 120
  121 LNKLQPIN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.459 a.118.8 TPR-like
View Download 0.504 c.95.1 Thiolase-like
View Download 0.561 c.78.1 Aspartate/ornithine carbamoyltransferase
View Download 0.487 a.47.2 t-snare proteins
View Download 0.497 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.561 c.78.1 Aspartate/ornithine carbamoyltransferase
View Download 0.504 c.95.1 Thiolase-like
View Download 0.497 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.487 a.47.2 t-snare proteins
View Download 0.459 a.118.8 TPR-like
View Download 0.434 a.24.11 Bacterial GAP domain
View Download 0.410 a.24.4 Hemerythrin
View Download 0.407 a.1.1 Globin-like
View Download 0.404 a.1.1 Globin-like
View Download 0.384 a.24.9 alpha-catenin/vinculin
View Download 0.373 c.23.1 CheY-like
View Download 0.368 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.349 f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.338 a.40.1 Calponin-homology domain, CH-domain
View Download 0.335 a.92.1 Carbamoyl phosphate synthetase, large subunit connection domain
View Download 0.335 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.327 a.22.1 Histone-fold
View Download 0.326 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.326 d.58.26 GHMP Kinase, C-terminal domain
View Download 0.322 d.13.1 HIT-like
View Download 0.320 d.146.1 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
View Download 0.317 d.205.1 GTP cyclohydrolase I feedback regulatory protein, GFRP
View Download 0.300 a.26.1 4-helical cytokines
View Download 0.296 a.92.1 Carbamoyl phosphate synthetase, large subunit connection domain
View Download 0.275 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.270 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.265 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.252 a.182.1 GatB/YqeY domain
View Download 0.247 a.7.1 Spectrin repeat
View Download 0.246 a.26.1 4-helical cytokines
View Download 0.242 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.237 d.26.1 FKBP-like
View Download 0.233 g.53.1 TAZ domain
View Download 0.229 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.225 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.223 a.7.6 Ribosomal protein S20
View Download 0.210 d.59.1 Ribosomal protein L30p/L7e
View Download 0.210 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

Predicted Domain #2
Region A:
Residues: [129-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDTVLITGTN APVLDLIDGS YTLAAEKIKP LKGLVSSHKR NISQVKIKFS LAYSSLLKLN  60
   61 KLLEYSSQVH EEINEISSKI EDDFLSLKNQ NHWYMRTVQK SIETLEKEVL QRKKSKKNIE 120
  121 MAQLESNDTI NHSKTELSLM SQDESINDDY GSIYSRFVQI KDRLDQLRFK KLYQLIGIFH 180
  181 STDLFN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.69897
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [315-439]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDRGYIYFEK PSSVNDVINR LKLKPLNIEI LLRQAGESTK HREYVNSQLG YYLLFLHLTA  60
   61 IQIFKAPLPY RLMYYGSTSV IDSQYPLYFT DQMISKHQAK LIKAIHYFNA DILQFKQILE 120
  121 NYRPT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.595 a.1.1 Globin-like
View Download 0.583 a.26.1 4-helical cytokines
View Download 0.701 a.74.1 Cyclin-like
View Download 0.648 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.572 a.74.1 Cyclin-like
View Download 0.555 a.1.1 Globin-like
View Download 0.554 a.4.5 "Winged helix" DNA-binding domain
View Download 0.493 a.63.1 Apolipophorin-III
View Download 0.490 d.233.1 Inhibitor of vertebrate lysozyme, Ivy
View Download 0.449 a.118.1 ARM repeat
View Download 0.439 a.1.1 Globin-like
View Download 0.438 a.7.7 BAG domain
View Download 0.434 a.39.1 EF-hand
View Download 0.428 a.24.3 Cytochromes
View Download 0.426 a.4.3 ARID-like
View Download 0.421 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.405 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.405 a.26.1 4-helical cytokines
View Download 0.405 a.118.11 Cytochrome c oxidase subunit E
View Download 0.401 a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.401 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.398 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.392 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.391 a.1.1 Globin-like
View Download 0.388 d.56.1 GroEL-intermediate domain like
View Download 0.388 c.23.1 CheY-like
View Download 0.377 a.24.3 Cytochromes
View Download 0.373 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.367 a.29.2 Bromodomain
View Download 0.362 d.185.1 LuxS/MPP-like metallohydrolase
View Download 0.360 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.351 c.78.2 Aspartate/glutamate racemase
View Download 0.349 a.19.1 Fertilization protein
View Download 0.349 d.58.22 TRADD, N-terminal domain
View Download 0.346 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.343 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.336 a.74.1 Cyclin-like
View Download 0.332 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.329 a.74.1 Cyclin-like
View Download 0.329 a.26.1 4-helical cytokines
View Download 0.322 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.321 d.198.2 Arp2/3 complex subunits
View Download 0.310 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.309 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.306 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.292 a.1.1 Globin-like
View Download 0.289 a.158.1 F-box domain
View Download 0.281 d.79.5 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF
View Download 0.274 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.272 c.110.1 D-Tyr tRNAtyr deacylase, DTD
View Download 0.271 a.4.3 ARID-like
View Download 0.269 a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.267 d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.265 f.18.1 F1F0 ATP synthase subunit A
View Download 0.264 a.1.1 Globin-like
View Download 0.264 d.110.4 SNARE-like
View Download 0.262 a.11.2 Second domain of FERM
View Download 0.261 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.261 a.74.1 Cyclin-like
View Download 0.260 d.189.1 PX domain
View Download 0.259 d.15.6 Superantigen toxins, C-terminal domain
View Download 0.259 a.74.1 Cyclin-like
View Download 0.251 a.148.1 Arp2/3 complex 21 kDa subunit ARPC3
View Download 0.249 a.4.12 TrpR-like
View Download 0.246 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.244 a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.244 d.54.1 Enolase N-terminal domain-like
View Download 0.242 d.6.1 Prion-like
View Download 0.241 a.68.1 Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
View Download 0.239 a.40.1 Calponin-homology domain, CH-domain
View Download 0.238 a.26.1 4-helical cytokines
View Download 0.238 a.24.17 Group V grass pollen allergen
View Download 0.236 a.25.1 Ferritin-like
View Download 0.231 a.1.1 Globin-like
View Download 0.226 d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.225 a.152.1 Antioxidant defence protein AhpD
View Download 0.224 a.39.1 EF-hand
View Download 0.224 a.118.1 ARM repeat
View Download 0.222 d.15.6 Superantigen toxins, C-terminal domain
View Download 0.221 c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.218 a.74.1 Cyclin-like
View Download 0.212 a.72.1 Functional domain of the splicing factor Prp18
View Download 0.211 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.209 a.47.2 t-snare proteins
View Download 0.208 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.206 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.204 a.3.1 Cytochrome c


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