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View Structure Prediction Details

Protein: RCK2
Organism: Saccharomyces cerevisiae
Length: 610 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RCK2.

Description E-value Query
Range
Subject
Range
RCK2 - Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of...
RCK2_YEAST - Serine/threonine-protein kinase RCK2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RCK...
gi|151941084 - gi|151941084|gb|EDN59464.1| conserved protein [Saccharomyces cerevisiae YJM789]
0.0 [1..610] [1..610]
gi|7339534 - gi|7339534|emb|CAB82852.1| protein kinase MK6 [Mesembryanthemum crystallinum]
0.0 [46..582] [17..547]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [121..582] [6..462]
gi|17381026, gi|... - gi|22331282|ref|NP_188973.2| protein kinase, putative [Arabidopsis thaliana], gi|20465361|gb|AAM2008...
0.0 [54..581] [16..537]
LATS2 - LATS, large tumor suppressor, homolog 2 (Drosophila)
0.0 [5..582] [520..1074]

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Predicted Domain #1
Region A:
Residues: [1-120]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKIKALFSK KKPDQADLSQ ESKKPFKGKT RSSGTNNKDV SQITSSPKKS FQDKNIVQYP  60
   61 SVVADDHHMK SLTDELVTTI DSDSSPSDNI TTENVETVTS VPAIDVHESS EGQLSSDPLI 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.791 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.791 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.513 a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.547 a.118.11 Cytochrome c oxidase subunit E
View Download 0.513 a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.547 a.118.11 Cytochrome c oxidase subunit E
View Download 0.475 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.475 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.452 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.452 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.406 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.402 a.29.2 Bromodomain
View Download 0.364 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.349 a.118.1 ARM repeat
View Download 0.338 a.118.8 TPR-like
View Download 0.338 a.1.1 Globin-like
View Download 0.328 a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.325 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.319 d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.310 a.54.1 Domain of early E2A DNA-binding protein, ADDBP
View Download 0.304 a.7.8 GAT domain
View Download 0.291 a.77.1 DEATH domain
View Download 0.271 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.262 a.1.1 Globin-like
View Download 0.258 a.29.4 RecG, N-terminal domain
View Download 0.250 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.250 d.58.26 GHMP Kinase, C-terminal domain
View Download 0.237 a.118.9 ENTH/VHS domain
View Download 0.230 a.118.9 ENTH/VHS domain
View Download 0.227 a.72.1 Functional domain of the splicing factor Prp18
View Download 0.222 c.23.1 CheY-like
View Download 0.220 a.24.15 FAD-dependent thiol oxidase
View Download 0.217 a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.207 a.3.1 Cytochrome c
View Download 0.205 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.204 a.39.1 EF-hand

Predicted Domain #2
Region A:
Residues: [121-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDESLSEQSE IISDIQDDST DDDNMEDEIP EKSFLEQKEL IGYKLINKIG EGAFSKVFRA  60
   61 IPAKNSSNEF LTKNYKAVAI KVIKKADLSS INGDHRKKDK GKDSTKTSSR DQVLKEVALH 120
  121 KTVSAGCSQI VAFIDFQETD SYYYIIQELL TG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 519.855515
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [273-532]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEIFGEIVRL TYFSEDLSRH VIKQLALAVK HMHSLGVVHR DIKPENLLFE PIEFTRSIKP  60
   61 KLRKSDDPQT KADEGIFTPG VGGGGIGIVK LADFGLSKQI FSKNTKTPCG TVGYTAPEVV 120
  121 KDEHYSMKVD MWGIGCVLYT MLCGFPPFYD EKIDTLTEKI SRGEYTFLKP WWDEISAGAK 180
  181 NAVAKLLELE PSKRYDIDQF LDDPWLNTFD CLPKEGESSQ KKAGTSERRH PHKKQFQLFQ 240
  241 RDSSLLFSPA AVAMRDAFDI 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 519.855515
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [533-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNAVKRTEED RMGTRGGLGS LAEDEELEDS YSGAQGDEQL EQNMFQLTLD TSTILQRRKK  60
   61 VQENDVGPTI PISATIRE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.373 a.64.1 Saposin
View Download 0.354 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.391 a.51.1 Cytochrome c oxidase subunit h
View Download 0.291 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.222 a.4.5 "Winged helix" DNA-binding domain
View Download 0.211 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.207 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.204 a.24.13 Domain of the SRP/SRP receptor G-proteins


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle