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View Structure Prediction Details

Protein: SAM1
Organism: Saccharomyces cerevisiae
Length: 382 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SAM1.

Description E-value Query
Range		 Subject
Range
METK_PHALU - S-adenosylmethionine synthase OS=Phaseolus lunatus GN=SAMS PE=2 SV=1
 0.0 [1..382] [1..389]
METK1_CATRO - S-adenosylmethionine synthase 1 OS=Catharanthus roseus GN=SAMS1 PE=1 SV=1
 0.0 [3..382] [2..388]
METK_POPDE - S-adenosylmethionine synthase OS=Populus deltoides GN=METK PE=2 SV=1
gi|497900 - gi|497900|gb|AAA20112.1| S-adenosyl methionine synthetase [Populus balsamifera subsp. trichocarpa x ...
 0.0 [1..382] [1..389]
METK2_SOLLC - S-adenosylmethionine synthase 2 OS=Solanum lycopersicum GN=SAM2 PE=2 SV=1
 0.0 [3..382] [2..388]
METK3_ORYSJ - S-adenosylmethionine synthase 3 OS=Oryza sativa subsp. japonica GN=METK3 PE=2 SV=1
 0.0 [3..382] [5..391]
METK_MESCR - S-adenosylmethionine synthase OS=Mesembryanthemum crystallinum GN=METK PE=2 SV=1
 0.0 [3..382] [2..387]
METK1_ORYSJ - S-adenosylmethionine synthase 1 OS=Oryza sativa subsp. japonica GN=SAM1 PE=2 SV=1
METK1_ORYSI - S-adenosylmethionine synthase 1 OS=Oryza sativa subsp. indica GN=SAM1 PE=2 SV=2
METK_ORYSA - S-adenosylmethionine synthetase 1 (EC 2.5.1.6) (Methionine adenosyltransferase 1) (AdoMet synthetase...
 0.0 [3..382] [5..391]
METK1_ELAUM - S-adenosylmethionine synthase 1 OS=Elaeagnus umbellata GN=SAMS1 PE=2 SV=1
 0.0 [3..382] [2..388]

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Predicted Domain #1
Region A:
Residues: [1-14] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGTFLFTSE SVGE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [130-239] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDETPEGLPL TILLAHKLNM AMADARRDGS LAWLRPDTKT QVTVEYKDDH GRWVPQRIDT  60
   61 VVVSAQHADE ITTEDLRAQL KSEIIEKVIP RDMLDENTKY FIQPSGRFVI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [251-275] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKIIVDAYGG ASSVGGGAFS GKDYS

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [353-371] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LARPIYLPTA SYGHFTNQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2570.0
Match: 1qm4A_
Description: S-adenosylmethionine synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methionine adenosyltransferase activity 8.00759843092519 bayes_pls_golite062009
transferase activity 1.78879119839291 bayes_pls_golite062009
binding 1.70779292877479 bayes_pls_golite062009
catalytic activity 1.59111295908728 bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups 1.11999094477144 bayes_pls_golite062009
protein binding 0.298204436433395 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [15-108] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHPDKICDQV SDAILDACLA EDPHSKVACE TAAKTGMIMV FGEITTKAQL DYQKIVRDTI  60
   61 KKIGYDDSAK GFDYKTCNVL VAIEQQSPDI AQGV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [240-250] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGPQGDAGLT G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2570.0
Match: 1qm4A_
Description: S-adenosylmethionine synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [109-129] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HEEKDLEDIG AGDQGIMFGY A

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [276-352] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVDRSAAYAA RWVAKSLVAA GLCKRVQVQF SYAIGIAEPL SLHVDTYGTA TKSDEEIIDI  60
   61 ISKNFDLRPG VLVKELD

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [372-382] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPWEKPKTLK F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2570.0
Match: 1qm4A_
Description: S-adenosylmethionine synthetase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle