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View Structure Prediction Details

Protein: SEN2
Organism: Saccharomyces cerevisiae
Length: 377 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEN2.

Description E-value Query
Range
Subject
Range
SEN2 - Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; S...
gi|190406141 - gi|190406141|gb|EDV09408.1| tRNA splicing endonuclease subunit [Saccharomyces cerevisiae RM11-1a]
SEN2_YEAST - tRNA-splicing endonuclease subunit SEN2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
gi|151941272 - gi|151941272|gb|EDN59650.1| tRNA splicing endonuclease subunit [Saccharomyces cerevisiae YJM789]
0.0 [1..377] [1..377]
sen2 - tRNA-splicing endonuclease subunit Sen2
SEN2_SCHPO - Probable tRNA-splicing endonuclease subunit sen2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 248...
0.0 [7..377] [4..380]
gi|114679004, gi... - gi|114679014|ref|XP_001174914.1| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes], gi|114...
TSEN34 - tRNA splicing endonuclease 34 homolog (S. cerevisiae)
1.0E-61 [96..350] [73..308]
SEN22_ARATH - tRNA-splicing endonuclease subunit Sen2-2 OS=Arabidopsis thaliana GN=SEN2 PE=2 SV=1
3.0E-55 [155..377] [8..231]
SEN34_MOUSE - tRNA-splicing endonuclease subunit Sen34 OS=Mus musculus GN=Tsen34 PE=2 SV=2
9.0E-49 [96..350] [41..314]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKGRVNQKR YKYPLPIHPV DDLPELILHN PLSWLYWAYR YYKSTNALND KVHVDFIGDT  60
   61 TLHITVQDDK QMLYLWNNGF FGTGQFSRSE PTWKARTEAR LGLNDTPLHN RGGTKSNTET 120
  121 EMTLEKVTQQ RRLQRLEFKK ERAKLERELL ELRKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.260 0.729 mitochondrion c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.260 0.599 tRNA-intron endonuclease activity c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.259 0.117 tRNA-intron endonuclease activity d.58.7 RNA-binding domain, RBD
View Download 0.253 0.114 mitochondrion a.7.4 Smac/diablo
View Download 0.259 0.042 DNA binding d.58.7 RNA-binding domain, RBD
View Download 0.375 0.016 tRNA-intron endonuclease activity d.110.2 GAF domain-like
View Download 0.375 0.012 DNA binding d.110.2 GAF domain-like
View Download 0.246 0.008 tRNA-intron endonuclease activity a.24.11 Bacterial GAP domain
View Download 0.253 0.005 tRNA-intron endonuclease activity a.7.4 Smac/diablo
View Download 0.246 0.000 mitochondrion a.24.11 Bacterial GAP domain
View Download 0.245 N/A N/A d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.224 N/A N/A d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain

Predicted Domain #2
Region A:
Residues: [156-260]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGHIDEENIL LEKQRESLRK FKLKQTEDVG IVAQQQDISE SNLRDEDNNL LDENGDLLPL  60
   61 ESLELMPVEA MFLTFALPVL DISPACLAGK LFQFDAKYKD IHSFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.529817
Match: 1a79A_
Description: tRNA splicing endonuclease, C-terminal domain; tRNA splicing endonuclease EdnA, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.47870548102815 bayes_pls_golite062009
protein binding 0.382621269105676 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [261-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSYVIYHHYR SHGWCVRSGI KFGCDYLLYK RGPPFQHAEF CVMGLDHDVS KDYTWYSSIA  60
   61 RVVGGAKKTF VLCYVERLIS EQEAIALWKS NNFTKLFNSF QVGEVLYKRW VPGRNRD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.529817
Match: 1a79A_
Description: tRNA splicing endonuclease, C-terminal domain; tRNA splicing endonuclease EdnA, N-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle