YRC Public Data Repository - Protein Structure Prediction

Protein:	MLH2
Organism:	Saccharomyces cerevisiae
Length:	695 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MLH2.

Description	E-value	Query Range	Subject Range
gi\|189065468, gi... - gi\|557470\|gb\|AAA50390.1\| similar to S. cerevisiae PMS1 Swiss-Prot Accession Number P14242, S. cerevi...	433.0	[0..3]	[592..15]
gi\|114612035 - gi\|114612035\|ref\|XP_001141671.1\| PREDICTED: PMS2 postmeiotic segregation increased 2 isoform 2 [Pan ...	416.0	[0..3]	[592..15]
gi\|116221138, gi... - gi\|75820509\|ref\|ZP_00750554.1\| COG0187: Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV... tr\|A0A085RQ54\|A0... - DNA gyrase subunit B OS=Vibrio cholerae GN=gyrB PE=3 SV=1 gi\|254291124, gi... - gi\|254291124\|ref\|ZP_04961921.1\| DNA gyrase, subunit B [Vibrio cholerae AM-19226], gi\|197751544\|ref\|Y...	412.0	[0..3]	[478..19]
gi\|153223913, gi... - gi\|153223913\|ref\|ZP_01954129.1\| DNA gyrase, subunit B [Vibrio cholerae MAK 757], gi\|124117960\|gb\|EAY... gi\|153819850, gi... - gi\|153819850\|ref\|ZP_01972517.1\| DNA gyrase, subunit B [Vibrio cholerae NCTC 8457], gi\|126509611\|gb\|E... gi\|229508861, gi... - gi\|229508861\|ref\|ZP_04398352.1\| DNA gyrase subunit B [Vibrio cholerae B33], gi\|229354136\|gb\|EEO19068... GYRB_VIBCH - DNA gyrase subunit B OS=Vibrio cholerae GN=gyrB PE=3 SV=1 gi\|75829895, gi\|... - gi\|75829895\|ref\|ZP_00759184.1\| COG0187: Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV... gi\|227008140, gi... - gi\|227080252\|ref\|YP_002808803.1\| DNA gyrase, subunit B [Vibrio cholerae M66-2], gi\|227008140\|gb\|ACP0... gi\|75828133, gi\|... - gi\|75828133\|ref\|ZP_00757568.1\| COG0187: Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV... gi\|229508300, gi... - gi\|229508300\|ref\|ZP_04397804.1\| DNA gyrase subunit B [Vibrio cholerae BX 330286], gi\|229354573\|gb\|EE... gi\|121727887, gi... - gi\|75814471\|ref\|ZP_00745055.1\| COG0187: Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV... gi\|229346195, gi... - gi\|229517132\|ref\|ZP_04406578.1\| DNA gyrase subunit B [Vibrio cholerae RC9], gi\|229346195\|gb\|EEO11167... gi\|229369229, gi... - gi\|229606574\|ref\|YP_002877222.1\| DNA gyrase subunit B [Vibrio cholerae MJ-1236], gi\|229369229\|gb\|ACQ... GYRB_VIBCH - DNA gyrase subunit B OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=gyr...	411.0	[0..3]	[478..19]
gi\|78504652, gi\|... - gi\|78687578\|ref\|ZP_00852322.1\| DNA gyrase, B subunit [Shewanella sp. ANA-3], gi\|78504652\|gb\|EAP18201...	408.0	[0..3]	[478..20]

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Predicted Domain #1

Region A:
Residues: [1-221]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIHQLSPES QWKIVSSSFI YGPVAAVREL LDNSIDSGAK KVFIDVDSTT GGCEYISVKD  60
   61 DGSGVDIIDR PSMCLEYTTS KMSSLGDISI LTTLGFRGEA LFLLSNLCNQ KGSMQVETKT 120
  121 ADDVIGEKWL VDSKGGITNG KRYKVSCPVG TTVILRKLLG GLRARYLEIS SRPRKTFDEL 180
  181 IYLINHYSLI HRNIRFYFSL VSLQKNGAIE RKQMQETLDP K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	257.529817
Match:	1ea6A
Description:	DNA mismatch repair protein PMS2
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [222-394]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISRARSLSLL ARLKKPVPLN FIVEENFVID EKINLDLILP RMVPESDVIN IKRRFKFLSV  60
   61 NERALSLNLE TGKTISKLLS SIYRDFSLLD PMVWFINLNC DTKLLDVNIE PEKNDVMIKS 120
  121 FEVIFKKIEN KLKLLLEERI GIETNMLGDK HVQPSINEKT SPALVIPTPD AEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	257.529817
Match:	1ea6A
Description:	DNA mismatch repair protein PMS2
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [395-512]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EISKGCGAVS GKDKTDIPQK NSDLIVPTFY DEANLENTTI VAATPSPTKF SEDKALDEQT  60
   61 QLTISSYRSS SSGSMASEDS TNWRHNFQQE LSENSEVAGA GSSTLPSSLT YNYIETIP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [513-695]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENEDLELSKD ASISNPFMIT KIRNVNKKLS ENLLEAKRTS CGDANKRGMP NERQLSNTEK  60
   61 KELIKLQQTY GKRNNTVDMT IPRNSKKKVT DNYIKKASCM HKTRPKLMHF SEYTNNYVYT 120
  121 LKNEKIVKHD SDNFAKETLW LRSRDDATSP SSSLLQALRA HVKKPGHIEA TTNEWCLFTP 180
  181 DSP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits