YRC Public Data Repository - Protein Structure Prediction

Protein:	JLP1
Organism:	Saccharomyces cerevisiae
Length:	412 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for JLP1.

Description	E-value	Query Range	Subject Range
gi\|151941116 - gi\|151941116\|gb\|EDN59494.1\| dnaJ-like protein [Saccharomyces cerevisiae YJM789] JLP1_YEAST - Alpha-ketoglutarate-dependent sulfonate dioxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508 ... JLP1 - Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use...	0.0	[1..412]	[1..412]
gi\|189373761, gi... - gi\|189373761\|gb\|EDU92177.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC869], gi\|168786201\|... gi\|188999387, gi... - gi\|188999387\|gb\|EDU68373.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4076], gi\|168783221... gi\|169756183, gi... - gi\|170021255\|ref\|YP_001726209.1\| taurine dioxygenase [Escherichia coli ATCC 8739], gi\|169756183\|gb\|A... gi\|168800238, gi... - gi\|189377380\|gb\|EDU95796.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC508], gi\|168800238\|... gi\|208726398, gi... - gi\|208806597\|ref\|ZP_03248934.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4206], gi\|20872... gi\|13359879, gi\|... - gi\|15829676\|ref\|NP_308449.1\| taurine dioxygenase [Escherichia coli O157:H7 str. Sakai], gi\|13359879\|... gi\|195938569 - gi\|195938569\|ref\|ZP_03083951.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4024] gi\|124528915, gi... - gi\|124528915\|ref\|ZP_01700100.1\| Taurine dioxygenase [Escherichia coli B], gi\|124500252\|gb\|EAY47728.1... gi\|208822961, gi... - gi\|208822961\|ref\|ZP_03263279.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4042], gi\|20873... gi\|208815909, gi... - gi\|208815909\|ref\|ZP_03257088.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4045], gi\|20873... gi\|188015925, gi... - gi\|188015925\|gb\|EDU54047.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4113], gi\|168749818... gi\|189368052, gi... - gi\|189368052\|gb\|EDU86468.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4501], gi\|168761560... gi\|168756897, gi... - gi\|189355960\|gb\|EDU74379.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4401], gi\|168756897... gi\|168776339, gi... - gi\|187768267\|gb\|EDU32111.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4196], gi\|168776339... gi\|189362420, gi... - gi\|189362420\|gb\|EDU80839.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4486], gi\|168768306... gi\|209744492, gi... - pir\|\|B85532 taurine dioxygenase, 2-oxoglutarate-dependent [imported] - Escherichia coli (strain O157... gi\|15800098, gi\|... - gi\|15800098\|ref\|NP_286110.1\| taurine dioxygenase [Escherichia coli O157:H7 EDL933], gi\|12513209\|gb\|A... gi\|13359879, gi\|... - gi\|15829676\|ref\|NP_308449.1\| taurine dioxygenase [Escherichia coli O157:H7], gi\|13359879\|dbj\|BAB3384... gi\|217325762, gi... - gi\|217325762\|ref\|ZP_03441846.1\| taurine dioxygenase [Escherichia coli O157:H7 str. TW14588], gi\|2173... gi\|209160608, gi... - gi\|209399208\|ref\|YP_002269009.1\| taurine dioxygenase [Escherichia coli O157:H7 str. EC4115], gi\|2091... tr\|A0A0X8UG71\|A0... - Taurine dioxygenase OS=Escherichia coli (strain K12) GN=tauD PE=4 SV=1 gi\|242376150, gi... - gi\|251783877\|ref\|YP_002998181.1\| hypothetical protein B21_00322 [Escherichia coli BL21], gi\|24237615... gi\|194422154, gi... - gi\|83585708\|ref\|ZP_00924350.1\| COG2175: Probable taurine catabolism dioxygenase [Escherichia coli 10... gi\|253774647, gi... - gi\|254287240\|ref\|YP_003052988.1\| taurine dioxygenase [Escherichia coli BL21(DE3)], gi\|253976547\|gb\|A... gi\|254160437, gi... - gi\|254160437\|ref\|YP_003043545.1\| taurine dioxygenase [Escherichia coli B str. REL606], gi\|253972338\|... gi\|254590948, gi... - gi\|254791548\|ref\|YP_003076385.1\| taurine dioxygenase, 2-oxoglutarate-dependent [Escherichia coli O15...	8.0E-66	[110..395]	[2..282]
gi\|238899661, gi... - gi\|238899661\|ref\|YP_002925457.1\| taurine dioxygenase, 2-oxoglutarate-dependent [Escherichia coli BW2... EG12423 - taurine dioxygenase, 2-oxoglutarate-dependent / Taurine /alpha-ketoglutarate dioxygenase gi\|188496113, gi... - gi\|75512431\|ref\|ZP_00734970.1\| COG2175: Probable taurine catabolism dioxygenase [Escherichia coli 53... gi\|89107239, gi\|... - gi\|89107239\|ref\|AP_001019.1\| taurine dioxygenase, 2-oxoglutarate-dependent [Escherichia coli str. K-... TAUD_ECOLI - Alpha-ketoglutarate-dependent taurine dioxygenase (EC 1.14.11.17) (2-aminoethanesulfonate dioxygenas... EG12423 - taurine dioxygenase, 2-oxoglutarate-dependent / Taurine /alpha-ketoglutarate dioxygenase gi\|170079957, gi... - gi\|170079957\|ref\|YP_001729277.1\| taurine dioxygenase, 2-oxoglutarate-dependent [Escherichia coli str... gi\|170683535, gi... - gi\|170683535\|ref\|YP_001742500.1\| taurine dioxygenase [Escherichia coli SMS-3-5], gi\|170521253\|gb\|ACB...	1.0E-65	[110..395]	[2..282]
gi\|149290172, gi... - gi\|150260764\|ref\|ZP_01917492.1\| putative taurine dioxygenase [Yersinia pestis CA88-4125], gi\|1492901... gi\|145209127, gi... - gi\|145597431\|ref\|YP_001161506.1\| taurine dioxygenase [Yersinia pestis Pestoides F], gi\|145209127\|gb\|... gi\|161511470 - gi\|161511470\|ref\|NP_991584.2\| taurine dioxygenase [Yersinia pestis biovar Microtus str. 91001] gi\|161484725 - gi\|161484725\|ref\|NP_671259.2\| taurine dioxygenase [Yersinia pestis KIM] gi\|162420117, gi... - gi\|77634624\|ref\|ZP_00796721.1\| COG2175: Probable taurine catabolism dioxygenase [Yersinia pestis Ang... gi\|165990611, gi... - gi\|166010521\|ref\|ZP_02231419.1\| alpha-ketoglutarate-dependent taurine dioxygenase [Yersinia pestis b... gi\|153947413, gi... - gi\|77631162\|ref\|ZP_00793748.1\| COG2175: Probable taurine catabolism dioxygenase [Yersinia pseudotube... gi\|165920109, gi... - gi\|165927833\|ref\|ZP_02223665.1\| alpha-ketoglutarate-dependent taurine dioxygenase [Yersinia pestis b... gi\|167399106, gi... - gi\|167399106\|ref\|ZP_02304630.1\| alpha-ketoglutarate-dependent taurine dioxygenase [Yersinia pestis b... gi\|166205443, gi... - gi\|166213145\|ref\|ZP_02239180.1\| alpha-ketoglutarate-dependent taurine dioxygenase [Yersinia pestis b... gi\|218927394, gi... - gi\|218927394\|ref\|YP_002345269.1\| taurine dioxygenase [Yersinia pestis CO92], gi\|16120526\|ref\|NP_4038... gi\|108814042, gi... - gi\|229904575\|ref\|ZP_04519686.1\| putative taurine dioxygenase [Yersinia pestis Nepal516], gi\|22967869... gi\|51591291, gi\|... - gi\|51598009\|ref\|YP_072200.1\| taurine dioxygenase [Yersinia pseudotuberculosis IP 32953], gi\|51591291... Q664Q0\|Q664Q0_YERPS - Putative taurine dioxygenase - Yersinia pseudotuberculosis gi\|89103007, gi\|... - gi\|89103007\|ref\|ZP_01175605.1\| COG2175: Probable taurine catabolism dioxygenase [Yersinia pestis bio... gi\|108781191, gi... - gi\|108809278\|ref\|YP_653194.1\| taurine dioxygenase [Yersinia pestis Antiqua], gi\|108781191\|gb\|ABG1524... gi\|167425659, gi... - gi\|167425659\|ref\|ZP_02317412.1\| alpha-ketoglutarate-dependent taurine dioxygenase [Yersinia pestis b... gi\|166962823, gi... - gi\|167418829\|ref\|ZP_02310582.1\| alpha-ketoglutarate-dependent taurine dioxygenase [Yersinia pestis b... gi\|169749056, gi... - gi\|170022522\|ref\|YP_001719027.1\| taurine dioxygenase [Yersinia pseudotuberculosis YPIII], gi\|1697490... gi\|167468833 - gi\|167468833\|ref\|ZP_02333537.1\| alpha-ketoglutarate-dependent taurine dioxygenase [Yersinia pestis F... gi\|186700231, gi... - gi\|186897205\|ref\|YP_001874317.1\| taurine dioxygenase [Yersinia pseudotuberculosis PB1/+], gi\|1867002... gi\|229706401, gi... - gi\|229836333\|ref\|ZP_04456500.1\| putative taurine dioxygenase [Yersinia pestis Pestoides A], gi\|22970... gi\|229840043, gi... - gi\|229840043\|ref\|ZP_04460202.1\| putative taurine dioxygenase [Yersinia pestis biovar Orientalis str.... gi\|229842125, gi... - gi\|229842125\|ref\|ZP_04462280.1\| putative taurine dioxygenase [Yersinia pestis biovar Orientalis str.... gi\|25351103 - pir\|\|AE0023 probable taurine dioxygenase tauD [imported] - Yersinia pestis (strain CO92)	2.0E-65	[111..395]	[3..282]
TFDA_ALCEU - (P10088) Alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase (EC 1.14.11.-) (2,4-D ... gi\|141977 - gi\|141977\|gb\|AAA21983.1\| 2,4-dichlorophenoxyacetate monooxygenase (gtg start codon) gi\|194245741 - gi\|194245741\|gb\|ACF35489.1\| TfdA [Burkholderia sp. TFD19] gi\|194245743 - gi\|194245743\|gb\|ACF35490.1\| TfdA [Cupriavidus sp. TFD33] gi\|194245745 - gi\|194245745\|gb\|ACF35491.1\| TfdA [Cupriavidus sp. TFD38] gi\|194245747 - gi\|194245747\|gb\|ACF35492.1\| TfdA [Pseudomonas sp. TFD39] TFDA_CUPPJ - Alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase OS=Cupriavidus pinatubonensis (... gi\|194245749 - gi\|194245749\|gb\|ACF35493.1\| TfdA [Pseudomonas sp. TFD51]	1.0E-64	[112..392]	[2..287]
gi\|194245731 - gi\|194245731\|gb\|ACF35484.1\| TfdA [Pseudomonas sp. TFD50] gi\|194245729 - gi\|194245729\|gb\|ACF35483.1\| TfdA [Pseudomonas putida] gi\|194245727 - gi\|194245727\|gb\|ACF35482.1\| TfdA [Cupriavidus respiraculi] gi\|15026872 - gi\|15026872\|gb\|AAK81681.1\| 2,4-D/alpha-ketoglutarate dioxygenase [Burkholderia cepacia] gi\|194245725 - gi\|194245725\|gb\|ACF35481.1\| TfdA [Cupriavidus sp. TFD40] gi\|194245723 - gi\|194245723\|gb\|ACF35480.1\| TfdA [Cupriavidus sp. TFD45] gi\|194245721 - gi\|194245721\|gb\|ACF35479.1\| TfdA [Variovorax koreensis]	1.0E-63	[112..392]	[2..287]
TFDA_BURSR - Alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase OS=Burkholderia sp. (strain RAS...	1.0E-63	[112..396]	[2..291]
gi\|28923217, gi\|... - gi\|32412139\|ref\|XP_326550.1\| predicted protein [Neurospora crassa], gi\|28923217\|gb\|EAA32433.1\| conse... gi\|85104107 - gi\|85104107\|ref\|XP_961669.1\| hypothetical protein NCU01057 [Neurospora crassa OR74A]	5.0E-63	[31..387]	[21..372]
ATSK_PSEPU - Alpha-ketoglutarate-dependent sulfate ester dioxygenase OS=Pseudomonas putida GN=atsK PE=1 SV=1	1.0E-62	[102..392]	[4..288]
gi\|11349512 - pir\|\|F83356 hypothetical protein PA2310 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|9948343, gi\|1... - gi\|9948343\|gb\|AAG05698.1\|AE004657_5 hypothetical protein PA2310 [Pseudomonas aeruginosa PAO1], gi\|15... gi\|218771942, gi... - gi\|218891716\|ref\|YP_002440583.1\| putative taurine catabolism dioxygenase [Pseudomonas aeruginosa LES... gi\|194546305, gi... - gi\|254235320\|ref\|ZP_04928643.1\| hypothetical protein PACG_01220 [Pseudomonas aeruginosa C3719], gi\|1...	1.0E-61	[112..391]	[14..294]

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Predicted Domain #1

Region A:
Residues: [1-91]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPAAAQTAI PLPSTDLPVK IITNGLKNLN YTSKQGYGNF DTHFYDGQDE VSPSGLLKIR  60
   61 KSYREKSKYP DYLPTWDPTE KYGPLEFHEY H

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.209	a.64.1	Saposin
View	Download	0.220	a.4.12	TrpR-like
View	Download	0.527	a.60.1	SAM/Pointed domain
View	Download	0.307	a.60.3	C-terminal domain of RNA polymerase alpha subunit
View	Download	0.235	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.228	d.13.1	HIT-like

Predicted Domain #2

Region A:
Residues: [92-249]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPALRADGNF SNLFAKENVG QLKVKKITPK LGLEINGIQL TDLSDAAKDE LALLVAQKGV  60
   61 VVFRNQNFAD EGPDYVTEYG RHFGKLHIHQ TSGHPQNNPE LHITFRRPDA EEFARVFDDS 120
  121 TSSGGWHTDV SYELQPPSYT FFSVVEGPDG GGDTLFAD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [344-388]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDLQLRAKWE PHSVVIWDNR RVQHSAVIDW EEPIHRHAFR ITPQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	386.522879
Match:	1gy9A_
Description:	Taurine/alpha-ketoglutarate dioxygenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	1.45256699472411	bayes_pls_golite062009
catalytic activity	0.921320409505	bayes_pls_golite062009
oxidoreductase activity	0.700777872792887	bayes_pls_golite062009
binding	0.525807098218081	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	0.15567515806758	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [250-343]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIEAFDRLSK PLQDFLSTLH VIHSSKEQAE NSQRQGGIKR RAPVTHIHPL VRVHPVLKKK  60
   61 CLYVNRAFSR KIVELKRQES ESLLNFLYNL VESS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [389-412]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERPVEDLKFL NDENYYPSSL TLDI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	386.522879
Match:	1gy9A_
Description:	Taurine/alpha-ketoglutarate dioxygenase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: