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View Structure Prediction Details

Protein: ENT4
Organism: Saccharomyces cerevisiae
Length: 247 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENT4.

Description E-value Query
Range		 Subject
Range
gi|147906994, gi... - gi|2072301|gb|AAC60123.1| mitotic phosphoprotein 90 [Xenopus laevis], gi|147906994|ref|NP_001081892....
 3.0E-82 [11..226] [7..265]
gi|119592811, gi... - gi|194248095|ref|NP_001123544.1| epsin 1 isoform b [Homo sapiens], gi|119592814|gb|EAW72408.1| epsin...
 2.0E-80 [11..226] [16..269]
EPN1_RAT - Epsin-1 OS=Rattus norvegicus GN=Epn1 PE=1 SV=1
 1.0E-79 [11..226] [16..269]
ENT4_YEAST - Epsin-4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ENT4 PE=1 SV=1
ENT4 - Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in th...
 1.0E-76 [1..247] [1..247]
lqf-PB, lqf-PD - The gene liquid facets is referred to in FlyBase by the symbol Dmel\lqf (CG8532, FBgn0028582). It is...
 1.0E-76 [11..231] [18..285]
EPN3_MOUSE - Epsin-3 OS=Mus musculus GN=Epn3 PE=1 SV=1
 9.0E-70 [11..209] [16..247]

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Predicted Domain #1
Region A:
Residues: [1-162] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLLDTFKSF IQSPTESKVK QATNEDETSG ATGTLMNEIS ILTYSPKTVR EIIQVIRKRL  60
   61 LLGQNRRNSH RNCIQVMKTL TLVSYLMNNG SNEFIKWLKG NMILIEILED FQVQDPRDER 120
  121 KAEDIQKLSR NVLGLLQDDG LLEKQRKDVI QFRSSISTPG RK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 172.165202
Match: 1eyhA_
Description: Epsin 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 2.70535896247543 bayes_pls_golite062009
binding 2.34501465852339 bayes_pls_golite062009
protein binding 1.97365365208963 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.20269437433936 bayes_pls_golite062009
phosphoinositide binding 0.87586037360588 bayes_pls_golite062009
phospholipid binding 0.84481265656013 bayes_pls_golite062009
lipid binding 0.176990783274449 bayes_pls_golite062009
GTPase binding 0.0887270623721197 bayes_pls_golite062009
small GTPase binding 0.0268749201897704 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [163-247] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STDNSHLKLE EMRSELTRQS LEKKAKPPTT STSLDFQRQR TRNTHEYARF SLDPLAEEDS  60
   61 EDTPGVAGGI SKLSFRPKSS NNPFR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle