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View Structure Prediction Details

Protein: VBA5
Organism: Saccharomyces cerevisiae
Length: 582 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VBA5.

Description E-value Query
Range
Subject
Range
VBA5_YEAST - Vacuolar basic amino acid transporter 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
VBA5 - Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid...
3.0E-88 [1..582] [1..582]
gi|21225257, gi|... - gi|7649556|emb|CAB89031.1| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi|...
2.0E-80 [1..572] [1..525]
gi|16944692 - gi|16944692|emb|CAC28808.2| related to tetracycline efflux protein (otrb) [Neurospora crassa]
7.0E-75 [3..582] [2..575]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
7.0E-74 [3..566] [13..530]
gi|15528453 - gi|15528453|emb|CAC69145.1| putative membrane protein [Pichia anomala]
1.0E-72 [2..578] [65..608]
gi|19386936 - gi|19386936|gb|AAL87047.1|AF448056_3 putative dothistromin transporter [Mycosphaerella pini]
gi|19386936 - gi|19386936|gb|AAL87047.1|AF448056_3 putative dothistromin transporter [Mycosphaerella pini]
1.0E-72 [2..574] [25..574]
gi|25498023 - pir||D96902 MDR-type permease [imported] - Clostridium acetobutylicum
gi|15893318, gi|... - gi|15893318|ref|NP_346667.1| MDR-type permease [Clostridium acetobutylicum ATCC 824], gi|15022839|gb...
2.0E-72 [34..499] [4..418]
gi|14389419 - gi|14389419|gb|AAF64435.2|AF238225_1 DHA14-like major facilitator [Botryotinia fuckeliana]
3.0E-71 [2..572] [68..594]

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Predicted Domain #1
Region A:
Residues: [1-242]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEETKYSSQQ EIEGACGSDA SLNARGSNDS PMGLSLYLCL ASLTLVLFIT ALDILIVGTI  60
   61 IDVVAEQFGN YSKTGWLVTG YSLPNAILSL IWGRFASIIG FQHSLILAIL IFEAGSLIAA 120
  121 LASSMNMLIF GRVVAGVGGS GLQTLCFVIG CTMVGERSRP LVISILSCAF AVAAIVGPII 180
  181 GGAFTTHVTW RWCFYINLPI GGLAIIMFLL TYKAENKGIL QQIKDAIGTI SSFTFSKFRH 240
  241 QV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.154902
Match: 1lviA_
Description: No description for 1lviA_ was found.

Predicted functions:

Term Confidence Notes
transporter activity 4.09176719149278 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.54194478414824 bayes_pls_golite062009
ion transmembrane transporter activity 2.21266150105753 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.15783210522667 bayes_pls_golite062009
cation transmembrane transporter activity 1.79369588808394 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
binding 1.01584233411372 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
cation:sugar symporter activity 0.143419068761182 bayes_pls_golite062009
sugar:hydrogen symporter activity 0.143419068761182 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [243-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFKRLMNGII FKFDFFGFAL CSAGLVLFLL GLTFGGNKYS WNSGQVITYL VLGVLLFIFS  60
   61 LVYDFFLFDK FN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [315-526]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEPDNISYRP LLLRRLVAKP AIIIVNMVTF LLCTGYNGQM IYSVQFFQLI FASSAWKAGL  60
   61 HLIPIVITNV IAAIASGVIT KKLGLVKPLL IFGGVLGVIG AGLMTLMTNT STKSTQIGVL 120
  121 LLPGFSLGFA LQASLMSAQL QITKDRPEAA MDFIEVTAFN TFMKSLGTTL GGVLSTTVFS 180
  181 ASFHNKVSRA HLEPYEGKTV DDMILYRLQN YD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [527-582]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSHSTIGNIL SDSIKNVFWM DLGFYALGFL FCSFSSNKKL IIPKKDDTPE DNLEDK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle