YRC Public Data Repository - Protein Structure Prediction

Protein:	MCH2
Organism:	Saccharomyces cerevisiae
Length:	473 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCH2.

Description	E-value	Query Range	Subject Range
MCH2 - Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of m...	5.0E-63	[1..473]	[1..473]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	8.0E-61	[30..472]	[8..481]
MOT1_CRILO - Monocarboxylate transporter 1 OS=Cricetulus longicaudatus GN=SLC16A1 PE=1 SV=1 tr\|G3IDS7\|G3IDS7... - Monocarboxylate transporter 1 OS=Cricetulus griseus GN=I79_021860 PE=4 SV=1 gi\|472333 - gi\|472333\|gb\|AAB59731.1\| monocarboxylate transporter 1	1.0E-60	[30..472]	[8..481]
MOT1_MOUSE - Monocarboxylate transporter 1 OS=Mus musculus GN=Slc16a1 PE=1 SV=1	8.0E-59	[30..472]	[8..480]
gi\|1661219 - gi\|1661219\|gb\|AAC44538.1\| ProP [Escherichia coli]	2.0E-57	[37..464]	[20..482]
gi\|110644469, gi... - gi\|110644469\|ref\|YP_672199.1\| proline/glycine betaine transporter [Escherichia coli 536], gi\|1103460... PROP_ECO57 - Proline/betaine transporter OS=Escherichia coli O157:H7 GN=proP PE=3 SV=1 EG11612 - proline /glycine betaine transporter / Proline /betaine permease, minor; osmosensor /osmoregulator gi\|15804703, gi\|... - gi\|15804703\|ref\|NP_290744.1\| proline/glycine betaine transporter [Escherichia coli O157:H7 EDL933], ... gi\|13364570, gi\|... - gi\|15834347\|ref\|NP_313120.1\| proline/glycine betaine transporter [Escherichia coli O157:H7 str. Saka... PROP_ECOLI - Proline/betaine transporter (Proline porter II) (PPII) - Escherichia coli gi\|168755291, gi... - gi\|189357490\|gb\|EDU75909.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4401], gi\|1... gi\|188017559, gi... - gi\|188017559\|gb\|EDU55681.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4113], gi\|1... gi\|124501194, gi... - gi\|124527751\|ref\|ZP_01699186.1\| metabolite/H+ symporter, major facilitator superfamily (MFS) [Escher... gi\|238863280, gi... - gi\|238903219\|ref\|YP_002929015.1\| proline/glycine betaine transporter [Escherichia coli BW2952], gi\|2... gi\|194437276, gi... - gi\|83587236\|ref\|ZP_00925865.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|251787365, gi... - gi\|251787365\|ref\|YP_003001669.1\| hypothetical protein B21_03943 [Escherichia coli BL21], gi\|24237963... gi\|191173340, gi... - gi\|75239082\|ref\|ZP_00723062.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|253775260, gi... - gi\|254290795\|ref\|YP_003056543.1\| proline/glycine betaine transporter [Escherichia coli BL21(DE3)], g... gi\|188494432, gi... - gi\|75514870\|ref\|ZP_00737099.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|254164045, gi... - gi\|254164045\|ref\|YP_003047153.1\| proline/glycine betaine transporter [Escherichia coli B str. REL606... gi\|82779157, gi\|... - gi\|82779157\|ref\|YP_405506.1\| proline/glycine betaine transporter [Shigella dysenteriae Sd197], gi\|81... gi\|254796133, gi... - gi\|254796133\|ref\|YP_003080970.1\| proline/glycine betaine transporter [Escherichia coli O157:H7 str. ... gi\|89110832, gi\|... - gi\|89110832\|ref\|AP_004612.1\| proline/glycine betaine transporter [Escherichia coli str. K-12 substr.... EG11612 - proline /glycine betaine transporter / Proline /betaine permease, minor; osmosensor /osmoregulator gi\|208807066, gi... - gi\|208807066\|ref\|ZP_03249403.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4206], ... gi\|195935900 - gi\|195935900\|ref\|ZP_03081282.1\| proline/glycine betaine transporter [Escherichia coli O157:H7 str. E... gi\|208818646, gi... - gi\|208818646\|ref\|ZP_03258966.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4042], ... gi\|208733226, gi... - gi\|208811949\|ref\|ZP_03253278.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4045], ... gi\|217324260, gi... - gi\|217324260\|ref\|ZP_03440344.1\| proline/betaine transporter [Escherichia coli O157:H7 str. TW14588],... gi\|209400808, gi... - gi\|209400808\|ref\|YP_002273655.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4115],... gi\|218434823, gi... - gi\|218707726\|ref\|YP_002415245.1\| proline/glycine betaine transporter [Escherichia coli UMN026], gi\|2... gi\|218372761, gi... - gi\|218702775\|ref\|YP_002410404.1\| proline/glycine betaine transporter [Escherichia coli IAI39], gi\|21... gi\|168766380, gi... - gi\|189364250\|gb\|EDU82669.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4486], gi\|1... gi\|168760970, gi... - gi\|189368614\|gb\|EDU87030.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4501], gi\|1... gi\|168780533, gi... - gi\|189001735\|gb\|EDU70721.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4076], gi\|1... gi\|187769958, gi... - gi\|187769958\|gb\|EDU33802.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC4196], gi\|1... gi\|189379187, gi... - gi\|189379187\|gb\|EDU97603.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC508], gi\|16... gi\|168784738, gi... - gi\|189374791\|gb\|EDU93207.1\| proline/betaine transporter [Escherichia coli O157:H7 str. EC869], gi\|16... gi\|170083563, gi... - gi\|170083563\|ref\|YP_001732883.1\| proline/glycine betaine transporter [Escherichia coli str. K-12 sub... gi\|169756819, gi... - gi\|170021891\|ref\|YP_001726845.1\| proline/glycine betaine transporter [Escherichia coli ATCC 8739], g...	3.0E-57	[37..464]	[20..482]
gi\|194468743, gi... - gi\|194468743\|ref\|ZP_03074727.1\| proline/betaine transporter [Salmonella enterica subsp. enterica ser... gi\|197212561, gi... - gi\|197248858\|ref\|YP_002149205.1\| proline/betaine transporter [Salmonella enterica subsp. enterica se... gi\|197264002, gi... - gi\|197264002\|ref\|ZP_03164076.1\| proline/betaine transporter [Salmonella enterica subsp. enterica ser... gi\|199605388, gi... - gi\|200388290\|ref\|ZP_03214902.1\| proline/betaine transporter [Salmonella enterica subsp. enterica ser... gi\|195630582, gi... - gi\|195630582\|gb\|EDX49194.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|205342159, gi... - gi\|205342159\|gb\|EDZ28923.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|194403930, gi... - gi\|194445267\|ref\|YP_002043540.1\| proline/betaine transporter [Salmonella enterica subsp. enterica se... gi\|194406872, gi... - gi\|194448568\|ref\|YP_002048281.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ent... gi\|205330200, gi... - gi\|205330200\|gb\|EDZ16964.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|168231304, gi... - gi\|205334337\|gb\|EDZ21101.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|168243707, gi... - gi\|205337320\|gb\|EDZ24084.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|168263371, gi... - gi\|205347989\|gb\|EDZ34620.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... gi\|161617432, gi... - gi\|161617432\|ref\|YP_001591397.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ent... gi\|205323027, gi... - gi\|205323027\|gb\|EDZ10866.1\| proline/betaine transporter [Salmonella enterica subsp. enterica serovar... PROP_SALTY - Proline/betaine transporter OS=Salmonella typhimurium GN=proP PE=3 SV=2 PROP_SALTY - Proline/betaine transporter OS=Salmonella typhimurium GN=proP PE=3 SV=2 gi\|204927333, gi... - gi\|204927333\|ref\|ZP_03218535.1\| proline/betaine transporter [Salmonella enterica subsp. enterica ser... gi\|205355061, gi... - gi\|205355061\|ref\|YP_002228862.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ent... PROP_SALTY - Proline/betaine transporter OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=proP ... gi\|206711247, gi... - gi\|207859444\|ref\|YP_002246095.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ent... lcl\|NC_016856.1_... - [gene=proP] [protein=proline/glycine betaine transporter] [protein_id=YP_005240596.1] [location=4544...	3.0E-57	[21..466]	[7..484]
gi\|25301461, gi\|... - gi\|25301461\|pir\|\|AB1022 ProP [imported] - Salmonella enterica subsp. enterica serovar Typhi (strain ... gi\|29144459, gi\|... - gi\|29144459\|ref\|NP_807801.1\| proline/glycine betaine transporter [Salmonella enterica subsp. enteric... gi\|16762972 - gi\|16762972\|ref\|NP_458589.1\| proline/glycine betaine transporter [Salmonella enterica subsp. enteric... gi\|213052371 - gi\|213052371\|ref\|ZP_03345249.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ente... gi\|213608015 - gi\|213608015\|ref\|ZP_03368841.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ente... gi\|213852584 - gi\|213852584\|ref\|ZP_03382116.1\| proline/glycine betaine transporter [Salmonella enterica subsp. ente...	3.0E-57	[21..466]	[7..484]
MOT1_RAT - Monocarboxylate transporter 1 OS=Rattus norvegicus GN=Slc16a1 PE=1 SV=1	4.0E-57	[30..470]	[8..477]
gi\|2304801 - gi\|2304801\|gb\|AAB65515.1\| monocarboxylate transporter 1	6.0E-57	[30..470]	[8..477]

Back

Predicted Domain #1

Region A:
Residues: [1-76]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEERHEDHH RDVENKLNLN GKDDINGNTS ISIEVPDGGY GWFILLAFIL YNFSTWGANS  60
   61 GYAIYLAHYL ENNTFA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transporter activity	3.3426261924492	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.29689809004391	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
ion transmembrane transporter activity	1.94035843948137	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
cation transmembrane transporter activity	1.5181741634556	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
binding	0.805286077372817	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [77-473]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGSKLDYASI GGLAFSCGLF FAPVITWLYH IFSIQFIIGL GILFQGAALL LAAFSVTLWE  60
   61 IYLTQGVLIG FGLAFIFIPS VTLIPLWFRN KRSLASGIGT AGSGLGGIVF NLGMQSILQK 120
  121 RGVKWALIAQ CIICTSLSTI ALMLTRTTHQ GLRQHKRSYK FELLDYDVLS NFAVWLLFGF 180
  181 VSFAMLGYVV LLYSLSDFTV SLGYTSKQGS YVSCMVSVGS LLGRPIVGHI ADKYGSLTVG 240
  241 MILHLVMAIL CWAMWIPCKN LATAIRFGLL VGSIMGTIWP TIASIVTRIV GLQKLPGTFG 300
  301 STWIFMAAFA LVAPIIGLEL RSTDTNGNDY YRTAIFVGFA YFGVSLCQWL LRGFIIARDE 360
  361 IAVREAYSAD QNELHLNVKL SHMSKCLFRY KQLPRRV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.30103
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: