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View Structure Prediction Details

Protein: LOS1
Organism: Saccharomyces cerevisiae
Length: 1100 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LOS1.

Description E-value Query
Range		 Subject
Range
XPOT_YEAST - Exportin-T OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LOS1 PE=1 SV=1
LOS1 - Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after t...
 0.0 [1..1100] [1..1100]
XPOT - exportin, tRNA (nuclear export receptor for tRNAs)
 0.0 [14..1087] [10..952]
XPOT_SCHPO - Exportin-T OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=los1 PE=1 SV=1
SPBP8B7.09c - karyopherin
 0.0 [2..1099] [3..976]
xpo-3 - importin beta, nuclear transport factor status:Partially_confirmed UniProt:Q9GYQ7 protein_id:AAF9989...
 0.0 [17..843] [13..757]
IPO13_RAT - Importin-13 OS=Rattus norvegicus GN=Ipo13 PE=2 SV=1
 2.0E-81 [3..871] [24..786]

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Predicted Domain #1
Region A:
Residues: [1-434] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLERIQQLVN AVNDPRSDVA TKRQAIELLN GIKSSENALE IFISLVINEN SNDLLKFYGL  60
   61 STLIELMTEG VNANPNGLNL VKFEITKWLK FQVLGNKQTK LPDFLMNKIS EVLTTLFMLM 120
  121 YSDCNGNQWN SFFDDLMSLF QVDSAISNTS PSTDGNILLG LEFFNKLCLM INSEIADQSF 180
  181 IRSKESQLKN NNIKDWMRDN DIMKLSNVWF QCLKLDEQIV SQCPGLINST LDCIGSFISW 240
  241 IDINLIIDAN NYYLQLIYKF LNLKETKISC YNCILAIISK KMKPMDKLAF LNMINLTNEL 300
  301 TYYHQAISMN PQIITFDNLE VWESLTKLIT SFGIEFTIII EQVNDDQKLD TLYKQSVISN 360
  361 VDSILLEKII PILLEFMNNE FDSITAKTFP FWSNYLAFLK KYKASSPNFV PLHKDFLDNF 420
  421 QQICFKRMKF SDDE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [435-516] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTQDDFEEFN ETVRFKLKNF QEIIVVIDPS LFLNNISQEI SANLMNCKNE SWQIFELTIY  60
   61 QIFNLSECTK NNYFGLNKNE IM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.878 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.757 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.830 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.17 Group V grass pollen allergen
View Download 0.917 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.766 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.17 Group V grass pollen allergen
View Download 0.754 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.741 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.711 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.7.6 Ribosomal protein S20
View Download 0.702 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.696 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.670 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.659 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.64.1 Saposin
View Download 0.624 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.612 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.612 0.008 tRNA splicing, via endonucleolytic cleavage and ligation f.17.1 F1F0 ATP synthase subunit C
View Download 0.601 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.71.2 Helical domain of Sec23/24
View Download 0.574 0.008 tRNA splicing, via endonucleolytic cleavage and ligation f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.562 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.46.1 Methionine synthase domain
View Download 0.544 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.5 "Winged helix" DNA-binding domain
View Download 0.536 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.531 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.118.9 ENTH/VHS domain
View Download 0.526 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.15 FAD-dependent thiol oxidase
View Download 0.522 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.517 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.5 "Winged helix" DNA-binding domain
View Download 0.510 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.5.4 Elongation factor TFIIS domain 2
View Download 0.499 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.5 "Winged helix" DNA-binding domain
View Download 0.484 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.71.2 Helical domain of Sec23/24
View Download 0.482 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.118.1 ARM repeat
View Download 0.481 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.3.1 Cytochrome c
View Download 0.468 0.008 tRNA splicing, via endonucleolytic cleavage and ligation f.17.1 F1F0 ATP synthase subunit C
View Download 0.455 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.449 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.7.7 BAG domain
View Download 0.444 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.3.1 Cytochrome c
View Download 0.440 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.436 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.5 "Winged helix" DNA-binding domain
View Download 0.420 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.418 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.23.5 Hemolysin expression modulating protein HHA
View Download 0.414 0.008 tRNA splicing, via endonucleolytic cleavage and ligation d.54.1 Enolase N-terminal domain-like
View Download 0.413 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.39.1 EF-hand
View Download 0.407 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.406 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.17 Group V grass pollen allergen
View Download 0.401 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.65.1 Annexin
View Download 0.400 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.5 "Winged helix" DNA-binding domain
View Download 0.398 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.396 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.112.1 Description not found.
View Download 0.387 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.5 "Winged helix" DNA-binding domain
View Download 0.382 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.74.1 Cyclin-like
View Download 0.380 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.64.1 Saposin
View Download 0.375 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.7.6 Ribosomal protein S20
View Download 0.375 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.372 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.64.1 Saposin
View Download 0.369 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.5 "Winged helix" DNA-binding domain
View Download 0.367 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.7.7 BAG domain
View Download 0.366 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.5 "Winged helix" DNA-binding domain
View Download 0.362 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.46.1 Methionine synthase domain
View Download 0.362 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.71.2 Helical domain of Sec23/24
View Download 0.362 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.71.2 Helical domain of Sec23/24
View Download 0.361 0.008 tRNA splicing, via endonucleolytic cleavage and ligation d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.358 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.354 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.353 0.008 tRNA splicing, via endonucleolytic cleavage and ligation d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.348 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.17.1 p8-MTCP1
View Download 0.348 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.340 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.339 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.118.1 ARM repeat
View Download 0.338 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.29.2 Bromodomain
View Download 0.338 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.85.1 Hemocyanin, N-terminal domain
View Download 0.337 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.118.9 ENTH/VHS domain
View Download 0.334 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.2.3 Chaperone J-domain
View Download 0.331 0.008 tRNA splicing, via endonucleolytic cleavage and ligation d.54.1 Enolase N-terminal domain-like
View Download 0.320 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.2.3 Chaperone J-domain
View Download 0.316 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.118.8 TPR-like
View Download 0.316 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.118.8 TPR-like
View Download 0.309 0.008 tRNA splicing, via endonucleolytic cleavage and ligation d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.307 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.17.1 p8-MTCP1
View Download 0.307 0.008 tRNA splicing, via endonucleolytic cleavage and ligation c.55.4 Translational machinery components
View Download 0.301 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.3 Cytochromes
View Download 0.290 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.15 FAD-dependent thiol oxidase
View Download 0.280 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.65.1 Annexin
View Download 0.280 0.008 tRNA splicing, via endonucleolytic cleavage and ligation d.8.1 Urease, gamma-subunit
View Download 0.275 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.275 0.008 tRNA splicing, via endonucleolytic cleavage and ligation f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.272 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.85.1 Hemocyanin, N-terminal domain
View Download 0.271 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.1 Homeodomain-like
View Download 0.266 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.112.1 Description not found.
View Download 0.264 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.21.1 HMG-box
View Download 0.260 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.259 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.126.1 Serum albumin-like
View Download 0.258 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.257 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.74.1 Cyclin-like
View Download 0.257 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.77.1 DEATH domain
View Download 0.256 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.256 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.255 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.255 0.008 tRNA splicing, via endonucleolytic cleavage and ligation c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.244 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.77.1 DEATH domain
View Download 0.240 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.29.4 RecG, N-terminal domain
View Download 0.239 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.238 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.237 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.236 0.008 tRNA splicing, via endonucleolytic cleavage and ligation d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.233 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.51.1 Cytochrome c oxidase subunit h
View Download 0.233 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.2.3 Chaperone J-domain
View Download 0.232 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.64.1 Saposin
View Download 0.228 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.1 Homeodomain-like
View Download 0.228 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.227 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.4.1 Homeodomain-like
View Download 0.226 0.008 tRNA splicing, via endonucleolytic cleavage and ligation d.54.1 Enolase N-terminal domain-like
View Download 0.220 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.220 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.60.9 lambda integrase-like, N-terminal domain
View Download 0.218 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.1.1 Globin-like
View Download 0.218 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.218 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.21.1 HMG-box
View Download 0.217 0.008 tRNA splicing, via endonucleolytic cleavage and ligation d.68.7 R3H domain
View Download 0.210 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.2.7 tRNA-binding arm
View Download 0.209 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.209 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.209 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.3.1 Cytochrome c
View Download 0.206 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.205 0.008 tRNA splicing, via endonucleolytic cleavage and ligation g.53.1 TAZ domain
View Download 0.204 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.47.2 t-snare proteins
View Download 0.202 0.008 tRNA splicing, via endonucleolytic cleavage and ligation a.118.11 Cytochrome c oxidase subunit E
View Download 0.201 0.008 tRNA splicing, via endonucleolytic cleavage and ligation b.40.4 Nucleic acid-binding proteins

Predicted Domain #3
Region A:
Residues: [517-1100] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSQPSLTLVR FLNELLMMKD FLLAIDNEQI QILFMELIVK NYNFIFSTSA NTANATDDDE  60
   61 KYLLILNIFM SSFAMFNKRE NVRLRSWYLF TRFLKLTRIN LKKILFANKN LVNEITNKIS 120
  121 PLLHIKVTSI NAQGTDDNDT IFDNQLYIFE GIGFIITLNN SSQELTAATA NTPIDYDILD 180
  181 QILTPLFTQL EGCITQGASP VVILECHHIL MAIGTLARGL HIGLVPENQV NNMVVNKKLI 240
  241 NDSLIHKFSN IAEVILVTFS FFNKFENIRD ASRFTFARLI PILSNKILPF INKLIELILS 300
  301 STDLKSWEMI DFLGFLSQLI HMFHTDTDCY QLFNQLLTPL INKVHSIIEE IDEQHDQQSS 360
  361 SNKPIDTAVT ATSVNKNIVV TDSYRDKILL KKAYCTFLQS FTNNSVTSIL LSDINRAILP 420
  421 VILNDLVTYT PQEIQETSMM KVSLNVLCNF IKCFGNGTCL DNDDINKDPN LKIDGLNEYF 480
  481 IMKCVPIIFE IPFNPIYKFN IKEGNFKTMA YDLARLLREL FIVSSNPTTN ENECVKYLTQ 540
  541 IYLPQIQLPQ ELTIQLVNML TTMGQKQFEK WFVDNFISVL KQGQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1013-1100] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKFNIKEGNF KTMAYDLARL LRELFIVSSN PTTNENECVK YLTQIYLPQI QLPQELTIQL  60
   61 VNMLTTMGQK QFEKWFVDNF ISVLKQGQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle