YRC Public Data Repository - Protein Structure Prediction

Protein:	SDH1
Organism:	Saccharomyces cerevisiae
Length:	640 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SDH1.

Description	E-value	Query Range	Subject Range
SDHA_YEAST - Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Saccharomyces cerevisiae... gi\|151941660 - gi\|151941660\|gb\|EDN60022.1\| succinate dehydrogenase flavoprotein subunit [Saccharomyces cerevisiae Y... SDH1 - Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxid...	0.0	[1..640]	[1..640]
SDHA_SCHPO - Probable succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Schizosaccharom... sdh1 - succinate dehydrogenase Sdh1	0.0	[1..640]	[1..641]
gi\|347134, gi\|47... - gi\|4759080\|ref\|NP_004159.1\| succinate dehydrogenase complex, subunit A, flavoprotein precursor [Homo...	0.0	[1..640]	[10..664]
gi\|15030102 - gi\|15030102\|gb\|AAH11301.1\| Sdha protein [Mus musculus]	0.0	[1..640]	[7..661]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[4..640]	[11..665]
SDHA_RAT - Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Rattus norvegicus GN=Sdh...	0.0	[1..640]	[10..656]
SdhA-PA, SdhA-PC... - The gene Succinate dehydrogenase A is referred to in FlyBase by the symbol Dmel\SdhA (CG17246, FBgn0... gi\|220955190, gi... - gi\|220955190\|gb\|ACL90138.1\| Scs-fp-PA [synthetic construct], gi\|220945436\|gb\|ACL85261.1\| Scs-fp-PA [...	0.0	[2..640]	[4..661]
gi\|6649876 - gi\|6649876\|gb\|AAF21611.1\|AF018287_5 SdhA; succinate dehydrogenase flavoprotein subunit [papaya bunch...	0.0	[46..640]	[5..596]

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Predicted Domain #1

Region A:
Residues: [1-247]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSLKKSALS KLTLLRNTRT FTSSALVRQT QGSVNGSASR SADGKYHIID HEYDCVVIGA  60
   61 GGAGLRAAFG LAEAGYKTAC ISKLFPTRSH TVAAQGGINA ALGNMHKDNW KWHMYDTVKG 120
  121 SDWLGDQDSI HYMTREAPKS IIELEHYGVP FSRTENGKIY QRAFGGQTKE YGKGAQAYRT 180
  181 CAVADRTGHA LLHTLYGQAL RHDTHFFIEY FALDLLTHNG EVVGVIAYNQ EDGTIHRFRA 240
  241 HKTIIAT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [404-489]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPTKWNGEAL TIDEETGEDK VIPGLMACGE AACVSVHGAN RLGANSLLDL VVFGRAVAHT  60
   61 VADTLQPGLP HKPLPSDLGK ESIANL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [619-640]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVIDHTLDEK ECPSVPPTVR AY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1177.0
Match:	1kf6A_
Description:	Fumarate reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [248-403]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGYGRAYFSC TSAHTCTGDG NAMVSRAGFP LQDLEFVQFH PSGIYGSGCL ITEGARGEGG  60
   61 FLVNSEGERF MERYAPTAKD LACRDVVSRA ITMEIREGRG VGKKKDHMYL QLSHLPPEVL 120
  121 KERLPGISET AAIFAGVDVT KEPIPIIPTV HYNMGG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [490-618]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKLRNANGSR STAEIRMNMK QTMQKDVSVF RTQSSLDEGV RNITAVEKTF DDVKTTDRSM  60
   61 IWNSDLVETL ELQNLLTCAS QTAVSAANRK ESRGAHARED YPNRDDEHWM KHTLSWQKDV 120
  121 AAPVTLKYR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1177.0
Match:	1kf6A_
Description:	Fumarate reductase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits