YRC Public Data Repository - Protein Structure Prediction

Protein:	PRR1
Organism:	Saccharomyces cerevisiae
Length:	518 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRR1.

Description	E-value	Query Range	Subject Range
PRR1_YEAST - Serine/threonine-protein kinase PRR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRR... PRR1 - Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possi...	0.0	[1..518]	[1..518]
gi\|458284 - gi\|458284\|gb\|AAA57318.1\| serine/threonine protein kinase	0.0	[2..513]	[116..579]
gi\|15072452 - gi\|15072452\|gb\|AAK40343.1\| protein kinase 1 [Cryphonectria parasitica]	0.0	[2..517]	[98..561]
gi\|12005625 - gi\|12005625\|gb\|AAG44542.1\|AF247001_1 protein kinase C [Blumeria graminis]	0.0	[4..517]	[621..1100]
PKL2_RAT, PKN2_RAT - (O08874) Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C-like 2) (Protein-kinase...	0.0	[35..517]	[350..789]
gi\|9716257 - gi\|9716257\|emb\|CAC01625.1\| protein kinase C homologue [Tuber borchii]	0.0	[5..517]	[637..1079]
gi\|16648134 - gi\|16648134\|gb\|AAL25332.1\| GH13631p [Drosophila melanogaster]	0.0	[94..517]	[128..489]
ENSMMUT000000444... - null, null, null, null gi\|149749105 - gi\|149749105\|ref\|XP_001492064.1\| PREDICTED: similar to protein kinase B gamma 1 isoform 2 [Equus cab... gi\|55665643, gi\|... - gi\|55666093\|emb\|CAH73072.1\| v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) ...	0.0	[136..517]	[88..414]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[136..517]	[88..414]
gi\|183396893, gi... - gi\|183396893\|gb\|AAI65948.1\| Protein kinase C, epsilon [synthetic construct], gi\|117616658\|gb\|ABK4234... KPCE_MOUSE - Protein kinase C epsilon type OS=Mus musculus GN=Prkce PE=1 SV=1	0.0	[102..517]	[315..677]

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Predicted Domain #1

Region A:
Residues: [1-128]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEYSSIYSQ PKTPRLKQEG FPDSIGDQHE KALIDENGEE DKKMASTEGT TGDSRSTPLT  60
   61 VSIPTFENVQ ALPTPMTYTP LSPGNLSMSP IDQSSLNIPK RRSHARLLDD MLSVTQPNQR 120
  121 VVSELIAP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.343	a.1.1	Globin-like
View	Download	0.213	c.95.1	Thiolase-like
View	Download	0.343	a.1.1	Globin-like
View	Download	0.213	c.95.1	Thiolase-like

Predicted Domain #2

Region A:
Residues: [129-173]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANLSPQRVVS LPTVTEEALV NDSVDSDNYT KEPYFPESSS STEKC

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [313-375]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDLLAAVMAR NGRLEAWLIQ RIFTEVVLAV KYLHENSIIH RDLKLENILL KYSFDDINSF  60
   61 RDS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [499-518]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INEIYESPFV KTIADTLSFS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	257.9897
Match:	1kmwC_
Description:	No description for 1kmwC_ was found.

Predicted Domain #3

Region A:
Residues: [174-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDDIFQGFLL DHWDRPLLWK KVRPIGSGNF STVLLYELMD QSNPKLKQVA VKRLKYPEEL  60
   61 SNVEQINTSL RYKETLSRLE NSLTRELQVL KSLNHPCIVK LLGINNPIFV TSKKPLCDLI 120
  121 IKTPRALPPC DMIMSYCPA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [376-498]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIYCKQNFIE LADFGLCKKI ENNEMCTARC GSEDYVSPEI LMGVPYDGHL SDTWALGVIL  60
   61 YSLFEDRLPF DPPPNASARQ RSRATSHRIA RFDWRWYRLS DYKTNVGKQI VENTLTRKNQ 120
  121 RWS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	257.9897
Match:	1kmwC_
Description:	No description for 1kmwC_ was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits