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View Structure Prediction Details

Protein: NFU1
Organism: Saccharomyces cerevisiae
Length: 256 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NFU1.

Description E-value Query
Range		 Subject
Range
NFU1 - Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required fo...
gi|207343478 - gi|207343478|gb|EDZ70927.1| YKL040Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190409786 - gi|190409786|gb|EDV13051.1| hypothetical protein SCRG_03979 [Saccharomyces cerevisiae RM11-1a]
NFU1_YEAST - NifU-like protein, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NFU1 PE...
 1.0E-87 [1..256] [1..256]
gi|6554171, gi|6... - gi|6760408|gb|AAF28338.1|AF213379_1 r10h10-like protein TO42 [Drosophila melanogaster], gi|6554171|g...
 2.0E-79 [13..252] [61..278]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-77 [11..256] [32..260]
NIFU5_ARATH - NifU-like protein 5, mitochondrial OS=Arabidopsis thaliana GN=NIFU5 PE=2 SV=1
 3.0E-77 [3..234] [56..268]
gi|28918289, gi|... - gi|32415477|ref|XP_328218.1| hypothetical protein [Neurospora crassa], gi|28918289|gb|EAA27966.1| HI...
gi|85083846 - gi|85083846|ref|XP_957202.1| HIRA-interacting protein 5 [Neurospora crassa OR74A]
 4.0E-73 [11..250] [72..308]
NFU1_MOUSE - NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Mus musculus GN=Nfu1 PE=1 SV=2
 1.0E-69 [10..235] [40..249]

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Predicted Domain #1
Region A:
Residues: [1-145] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKSVAKLGK SPIFYLNSQR LIHIKTLTTP NENALKFLST DGEMLQTRGS KSIVIKNTDE  60
   61 NLINHSKLAQ QIFLQCPGVE SLMIGDDFLT INKDRMVHWN SIKPEIIDLL TKQLAYGEDV 120
  121 ISKEFHAVQE EEGEGGYKIN MPKFE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.721 0.892 mitochondrial matrix d.185.1 LuxS/MPP-like metallohydrolase

Predicted functions:

Term Confidence Notes
catalytic activity 0.60409960326459 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [146-256] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEEDEEVSE LIEELIDTRI RPAILEDGGD IDYRGWDPKT GTVYLRLQGA CTSCSSSEVT  60
   61 LKYGIESMLK HYVDEVKEVI QIMDPEQEIA LKEFDKLEKK LESSKNTSHE K

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 40.091515
Match: PF01106
Description: NifU-like domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.71550813147686 bayes_pls_golite062009
2 iron, 2 sulfur cluster binding 1.15693786817459 bayes_pls_golite062009
iron-sulfur cluster binding 0.692336376163639 bayes_pls_golite062009
metal cluster binding 0.692336376163639 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle