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View Structure Prediction Details

Protein: NFU1
Organism: Saccharomyces cerevisiae
Length: 256 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NFU1.

Description E-value Query
Range
Subject
Range
NFU1 - Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required fo...
gi|207343478 - gi|207343478|gb|EDZ70927.1| YKL040Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190409786 - gi|190409786|gb|EDV13051.1| hypothetical protein SCRG_03979 [Saccharomyces cerevisiae RM11-1a]
NFU1_YEAST - NifU-like protein, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NFU1 PE...
1.0E-87 [1..256] [1..256]
gi|6554171, gi|6... - gi|6760408|gb|AAF28338.1|AF213379_1 r10h10-like protein TO42 [Drosophila melanogaster], gi|6554171|g...
2.0E-79 [13..252] [61..278]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-77 [11..256] [32..260]
NIFU5_ARATH - NifU-like protein 5, mitochondrial OS=Arabidopsis thaliana GN=NIFU5 PE=2 SV=1
3.0E-77 [3..234] [56..268]
gi|28918289, gi|... - gi|32415477|ref|XP_328218.1| hypothetical protein [Neurospora crassa], gi|28918289|gb|EAA27966.1| HI...
gi|85083846 - gi|85083846|ref|XP_957202.1| HIRA-interacting protein 5 [Neurospora crassa OR74A]
4.0E-73 [11..250] [72..308]
NFU1_MOUSE - NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Mus musculus GN=Nfu1 PE=1 SV=2
1.0E-69 [10..235] [40..249]

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Predicted Domain #1
Region A:
Residues: [1-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKSVAKLGK SPIFYLNSQR LIHIKTLTTP NENALKFLST DGEMLQTRGS KSIVIKNTDE  60
   61 NLINHSKLAQ QIFLQCPGVE SLMIGDDFLT INKDRMVHWN SIKPEIIDLL TKQLAYGEDV 120
  121 ISKEFHAVQE EEGEGGYKIN MPKFE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.721 0.892 mitochondrial matrix d.185.1 LuxS/MPP-like metallohydrolase
View Download 0.711 0.003 mitochondrial matrix d.227.1 OsmC-like
View Download 0.545 0.000 mitochondrial matrix d.58.21 Molybdenum cofactor biosynthesis protein C, MoaC
View Download 0.588 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.480 N/A N/A d.185.1 LuxS/MPP-like metallohydrolase
View Download 0.462 N/A N/A d.58.8 Viral DNA-binding domain
View Download 0.439 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.407 N/A N/A d.89.1 Origin of replication-binding domain, RBD-like
View Download 0.405 N/A N/A d.58.21 Molybdenum cofactor biosynthesis protein C, MoaC
View Download 0.405 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.382 N/A N/A a.79.1 Antitermination factor NusB
View Download 0.337 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.335 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.323 N/A N/A d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.320 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.319 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.315 N/A N/A d.185.1 LuxS/MPP-like metallohydrolase
View Download 0.314 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.314 N/A N/A a.26.1 4-helical cytokines
View Download 0.303 N/A N/A c.95.1 Thiolase-like
View Download 0.302 N/A N/A d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.287 N/A N/A d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.286 N/A N/A d.58.48 MTH1187-like
View Download 0.285 N/A N/A d.110.1 Profilin (actin-binding protein)
View Download 0.277 N/A N/A d.58.41 SEA domain
View Download 0.275 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.274 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.274 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.255 N/A N/A d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.249 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.245 N/A N/A c.50.1 Macro domain-like
View Download 0.239 N/A N/A a.39.1 EF-hand
View Download 0.230 N/A N/A d.74.5 Hypothetical protein Yml108w
View Download 0.227 N/A N/A d.52.7 Ribosome-binding factor A, RbfA
View Download 0.226 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.223 N/A N/A a.3.1 Cytochrome c
View Download 0.221 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.212 N/A N/A d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.211 N/A N/A d.163.1 DNA breaking-rejoining enzymes
View Download 0.210 N/A N/A d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.208 N/A N/A a.185.1 Gametocyte protein Pfg27
View Download 0.206 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.204 N/A N/A d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.200 N/A N/A d.74.5 Hypothetical protein Yml108w

Predicted functions:

Term Confidence Notes
catalytic activity 0.60409960326459 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [146-256]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEEDEEVSE LIEELIDTRI RPAILEDGGD IDYRGWDPKT GTVYLRLQGA CTSCSSSEVT  60
   61 LKYGIESMLK HYVDEVKEVI QIMDPEQEIA LKEFDKLEKK LESSKNTSHE K

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 40.091515
Match: PF01106
Description: NifU-like domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.71550813147686 bayes_pls_golite062009
2 iron, 2 sulfur cluster binding 1.15693786817459 bayes_pls_golite062009
iron-sulfur cluster binding 0.692336376163639 bayes_pls_golite062009
metal cluster binding 0.692336376163639 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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