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View Structure Prediction Details

Protein: MPH3
Organism: Saccharomyces cerevisiae
Length: 602 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MPH3.

Description E-value Query
Range		 Subject
Range
MPH3 - Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; iden...
MPH3_YEAST - Alpha-glucosides permease MPH3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MPH3 PE=1...
 0.0 [1..602] [1..602]
KHT2_KLULC - Hexose transporter 2 OS=Kluyveromyces lactis GN=KHT2 PE=3 SV=1
 0.0 [39..594] [1..559]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [89..596] [3..496]
STC_RICCO - Sugar carrier protein C OS=Ricinus communis GN=STC PE=2 SV=1
 0.0 [87..576] [15..507]
STP1_ARATH - Sugar transport protein 1 OS=Arabidopsis thaliana GN=STP1 PE=1 SV=2
 0.0 [87..575] [13..504]

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Predicted Domain #1
Region A:
Residues: [1-68] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNLSFLINR RKENTSDSNV YPGKAKSHEP SWIEMDDQTK KDGLDIVHVE FSPDTRAPSD  60
   61 SNKVITEI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.366 0.890 carbohydrate transport a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #2
Region A:
Residues: [69-291] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDATEDAKEA DESERGMPLA TALNTYPKAA AWSLLVSTTL IMEGYDTAIL GAFYALPIFQ  60
   61 RKFGSQNDKT GEWEISASWQ IGLTLCYMAG EIVGLQLTGP SVDLVGNRYT LIIALFFLAA 120
  121 FTFILYFCNS LGMIAVGQAL CGMPWGCFQC LTVSYASEIC PLALRYYLTT YSNLCWLFGQ 180
  181 LFAAGIMKNS QKKYADSELG YKLPFALQWI LPVPLALGIF FAP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [344-549] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKEGSYSDCF EDKINRRRTR ITCLCWAGQA TCGSILIGYS TYFYEKAGVS TEMSFTFSII  60
   61 QYCLGICATF LSWWASKYFG RYDLYAFGLA FQTIVFFIIG GLGCSSTHGS KMGSGSLLMA 120
  121 VAFFYNLGIA PVVFCLVSEM PSSRLRTKTI ILARNTYNVV SIICSVLILY QLNSKKWNWG 180
  181 AKSGFFWGVL CFCTLIWAVV DLPETA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 196.228787
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted functions:

Term Confidence Notes
transporter activity 4.09176719149278 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.54194478414824 bayes_pls_golite062009
hexose phosphate transmembrane transporter activity 3.3746965264994 bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity 3.3746965264994 bayes_pls_golite062009
sugar:hydrogen symporter activity 2.99050613058546 bayes_pls_golite062009
cation:sugar symporter activity 2.99050613058546 bayes_pls_golite062009
monosaccharide transmembrane transporter activity 2.63293544825311 bayes_pls_golite062009
carbohydrate transmembrane transporter activity 2.62141276633776 bayes_pls_golite062009
sugar transmembrane transporter activity 2.47557586092261 bayes_pls_golite062009
ion transmembrane transporter activity 2.21266150105753 bayes_pls_golite062009
solute:hydrogen symporter activity 2.10485633822652 bayes_pls_golite062009
cation transmembrane transporter activity 1.79369588808394 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
binding 0.873217664940684 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [292-343] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESPWWLVKKG RFDEARRSLR RTLSGKGPEK EILVTLEVDK IKVTIDKEKR LT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [550-602] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKTFVEINEL FKLGVSARKF KSTKVDPFVV KTPPKDVSHN DPKGDIEASI AEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 196.228787
Match: 1ja5A_
Description: No description for 1ja5A_ was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle