YRC Public Data Repository - Protein Structure Prediction

Protein:	STR2
Organism:	Saccharomyces cerevisiae
Length:	639 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STR2.

Description	E-value	Query Range	Subject Range
YML082W - Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fus... METX_YEAST - Putative cystathionine gamma-synthase YML082W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...	472.0	[0..2]	[638..6]
gi\|28883481 - gi\|28883481\|gb\|AAO46884.1\| methionine gamma-lyase [Citrobacter freundii]	447.0	[0..221]	[636..8]
gi\|21698926 - gi\|21698926\|dbj\|BAC02724.1\| L-methionine-alpha-deamino-gamma- mercaptomethane-lyase [Fusobacterium n... MEGL_FUSNP - L-methionine gamma-lyase OS=Fusobacterium nucleatum subsp. polymorphum GN=mgl PE=1 SV=1 gi\|197737499, gi... - gi\|254304388\|ref\|ZP_04971746.1\| methionine gamma-lyase [Fusobacterium nucleatum subsp. polymorphum A...	441.0	[0..215]	[635..1]
MEGL_FUSNN - L-methionine gamma-lyase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130...	439.0	[0..215]	[635..1]
gi\|75910353, gi\|... - gi\|75910353\|ref\|YP_324649.1\| cystathionine gamma-lyase [Anabaena variabilis ATCC 29413], gi\|75704078...	438.0	[0..222]	[633..3]
METB_HELPX - Cystathionine gamma-synthase OS=Helicobacter pylori GN=metB PE=1 SV=1	437.0	[0..221]	[635..2]
METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori (strain ATCC 700392 / 26695) GN=metB PE=1 SV=1 METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori GN=metB PE=3 SV=1	436.0	[0..221]	[635..2]
gi\|107836304, gi... - gi\|108562531\|ref\|YP_626847.1\| cystathionine gamma-synthase/cystathionine beta-lyase [Helicobacter py...	435.0	[0..221]	[635..2]
gi\|147676588, gi... - gi\|98660749\|dbj\|GAA02076.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476765...	431.0	[0..220]	[636..6]

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Predicted Domain #1

Region A:
Residues: [1-107]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISRTIGESI PPNTKHAVSV CLPTWEATVG YEEGESSIIN SLTTGYPRFF IHKSIKKLCE  60
   61 ILSAKYSMED EACLCFPSYK VANRCREFIK VKTGLSTKVR ILQLCTP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2.221849
Match:	1h7dA
Description:	Prepeptide of 5-ALAS
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [108-180]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPMNQEEKLW RRECKITVVF VDQEIFPVMK QYWQHSGEIV SSRMAEYILH ELQVKDNLKK  60
   61 METVDNGKKF MTE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.714	a.101.1	Uteroglobin-like
View	Download	0.600	a.56.1	CO dehydrogenase ISP C-domain like
View	Download	0.589	a.39.1	EF-hand
View	Download	0.589	a.39.1	EF-hand
View	Download	0.573	a.101.1	Uteroglobin-like
View	Download	0.473	a.64.1	Saposin
View	Download	0.444	a.56.1	CO dehydrogenase ISP C-domain like

Predicted Domain #3

Region A:
Residues: [181-501]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DENRVNEEYI ETRFGRNLNF LAADKAKYLI RKRIATKVVE KIDSEGLSDL FSFEHYNESN  60
   61 GPFNVGSGEA LDDDQLNSDI PAETITSMGE SGSNSTFENT ATDDLKFHVN PNTDVYLFPS 120
  121 GMASIFTAHR LLLNFDAKRL SRSSSRQDKL IGYGPPFKKT VMFGFPYTDT LSILRKFNHT 180
  181 HFLGQGDSTS MNALKNILHS GEQILAVFIE APSNPLLKMG DLQELKRLSD LYSFYIVVDE 240
  241 TVGGFVNIDV LPYADIVCSS LTKIFSGDSN VIAGSLVLNP RGKIYEFARK FMKTEDGYED 300
  301 CLWCEDALCL ERNSRDFVER T

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	208.457575
Match:	1gc0A
Description:	Methionine gamma-lyase, MGL
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [502-639]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKVNTNTDIL LKRVLLPQVG KLFKKIYYPS LTSEDTKRNY DSVMSTKDGG YGGLFSLTFF  60
   61 NIEEAKKFFN NLELCKGPSL GTNFTLACPY AIIAHYQELD EVAQYGVETN LVRVSVGLEN 120
  121 SDVLCNVFQR AIEKALGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	208.457575
Match:	1gc0A
Description:	Methionine gamma-lyase, MGL
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits