YRC Public Data Repository - Protein Structure Prediction

Protein:	TMA22
Organism:	Saccharomyces cerevisiae
Length:	198 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TMA22.

Description	E-value	Query Range	Subject Range
TMA22 - Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; intera... DENR_YEAST - Translation machinery-associated protein 22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... gi\|207343896 - gi\|207343896\|gb\|EDZ71214.1\| YJR014Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190409501 - gi\|190409501\|gb\|EDV12766.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] DENR_YEAS7 - Translation machinery-associated protein 22 OS=Saccharomyces cerevisiae (strain YJM789) GN=TMA22 PE=...	4.0E-51	[1..184]	[1..184]
gi\|30793919, gi\|... - gi\|62319631\|dbj\|BAD95123.1\| hypothetical protein [Arabidopsis thaliana], gi\|51971214\|dbj\|BAD44299.1\|...	9.0E-48	[4..186]	[9..194]
gi\|4755083 - gi\|4755083\|gb\|AAC02985.2\| density regulated protein drp1 [Homo sapiens]	2.0E-47	[5..188]	[76..243]
DENR_SCHPO - Translation machinery-associated protein 22 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G... SPBC16C6.05 - translation initiation factor	1.0E-44	[2..190]	[9..189]
DENR_MOUSE - Density-regulated protein OS=Mus musculus GN=Denr PE=1 SV=1	1.0E-43	[5..188]	[31..198]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-43	[3..183]	[7..178]
gi\|12831046, gi\|... - gi\|13095857\|ref\|NP_076747.1\| Orf52 [Lactococcus phage bIL309], gi\|12831046\|gb\|AAK08400.1\|AF323670_52... gi\|15672462, gi\|... - gi\|15672462\|ref\|NP_266636.1\| prophage pi1 protein 45 [Lactococcus lactis subsp. lactis Il1403], gi\|1... gi\|25401036 - pir\|\|H86684 prophage pi1 protein 45, tail component [imported] - Lactococcus lactis subsp. lactis (s...	7.0E-31	[19..156]	[325..465]

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Predicted Domain #1

Region A:
Residues: [1-62]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLREVIYCGI CSYPPEYCEF SGKLKRCKVW LSENHADLYA KLYGTDDNTQ EVEAVTNKLA  60
   61 ES

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	1.36535619829821	bayes_pls_golite062009
translation initiation factor activity	0.221356879029422	bayes_pls_golite062009
nucleic acid binding	0.213614307171087	bayes_pls_golite062009
protein binding	0.189517592830504	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [63-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIGEAREEKL EKDLLKIQKK QENREQRELA KKLSSKVIIK REARTKRKFI VAISGLEVFD  60
   61 IDMKKLAKTF ASRFATGCSV SKNAEKKEEV VIQGDVMDEV ETYIHSLLEE KGLKDVKVET 120
  121 IDAKKKKKPA AEGAAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.221849
Match:	1d1rA_
Description:	YciH
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: