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View Structure Prediction Details

Protein: YJR008W
Organism: Saccharomyces cerevisiae
Length: 338 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YJR008W.

Description E-value Query
Range
Subject
Range
YJX8_YEAST - MEMO1 family protein YJR008W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YJR008W PE=...
YJR008W - Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-depend...
0.0 [1..338] [1..338]
gi|114576869 - gi|114576869|ref|XP_001164110.1| PREDICTED: chromosome 2 open reading frame 4 isoform 3 [Pan troglod...
MEMO1 - mediator of cell motility 1
gi|123982438, gi... - gi|123997099|gb|ABM86151.1| chromosome 2 open reading frame 4 [synthetic construct], gi|123982438|gb...
gi|126303134 - gi|126303134|ref|XP_001371460.1| PREDICTED: similar to CGI-27 protein [Monodelphis domestica]
MEMO1_MACFA - Protein MEMO1 OS=Macaca fascicularis GN=MEMO1 PE=2 SV=1
2.0E-99 [4..337] [8..296]
MEMO1_MOUSE - Protein MEMO1 OS=Mus musculus GN=Memo1 PE=1 SV=1
6.0E-99 [4..337] [8..296]
SPAC4H3.04c - UPF0103 family
YAY4_SCHPO - MEMO1 family protein C4H3.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC4H3.04c ...
2.0E-94 [2..333] [4..307]
Y539_PYRAB - MEMO1 family protein PYRAB05390 OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=PYRAB05390 PE=3 SV=1
Y539_PYRAB - UPF0103 protein PYRAB05390 OS=Pyrococcus abyssi GN=PYRAB05390 PE=3 SV=1
2.0E-88 [3..335] [2..289]
tag-253 - status:Confirmed UniProt:Q22915 protein_id:AAM29667.1
3.0E-87 [4..318] [11..280]
gi|25412293, gi|... - gi|4567249|gb|AAD23663.1| expressed protein [Arabidopsis thaliana], pir||E84646 hypothetical protein...
1.0E-85 [2..325] [3..277]
gi|3258055, gi|1... - gi|3258055|dbj|BAA30738.1| 294aa long hypothetical protein [Pyrococcus horikoshii OT3], gi|14591400|...
gi|7449984 - gi|7449984|pir||B71042 hypothetical protein PH1626 - Pyrococcus horikoshii
2.0E-85 [3..335] [5..292]
YG38_PYRFU, Y163... - (Q8U0F2) Hypothetical UPF0103 protein PF1638, UPF0103 protein PF1638 OS=Pyrococcus furiosus GN=PF163...
Y1638_PYRFU - MEMO1 family protein PF1638 OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) G...
2.0E-83 [3..335] [2..289]
Y045_METTH - MEMO1 family protein MTH_45 OS=Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 ...
gi|7388365, gi|7... - gi|7449979|pir||G69158 conserved hypothetical protein MTH45 - Methanobacterium thermoautotrophicum (...
1.0E-78 [3..331] [2..274]

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Predicted Domain #1
Region A:
Residues: [1-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIRPATHAG SWYSNRAQEL SQQLHTYLIK STLKGPIHNA RIIICPHAGY RYCGPTMAYS  60
   61 YASLDLNRNV KRIFILGPSH HIYFKNQILV SAFSELETPL GNLKVDTDLC KTLIQKEYPE 120
  121 NGKKLFKPMD HDTDMAEHSL EMQLPMLVET LKWREISLDT VKVFPMMVSH NSVDVDRCIG 180
  181 NILSEYIKDP NNLFIVSSDF CHWGRRFQYT GYV

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 12.21
Match: 1b4uB
Description: LigB subunit of an aromatic-ring-opening dioxygenase LigAB
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [214-338]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSKEELNDAI QEETEVEMLT ARSKLSHHQV PIWQSIEIMD RYAMKTLSDT PNGERYDAWK  60
   61 QYLEITGNTI CGEKPISVIL SALSKIRDAG PSGIKFQWPN YSQSSHVTSI DDSSVSYASG 120
  121 YVTIG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.521 a.22.1 Histone-fold
View Download 0.537 a.74.1 Cyclin-like
View Download 0.581 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.652 a.24.4 Hemerythrin
View Download 0.549 a.24.17 Group V grass pollen allergen
View Download 0.518 d.82.2 Frataxin-like
View Download 0.454 a.24.3 Cytochromes
View Download 0.445 b.60.1 Lipocalins
View Download 0.434 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.423 a.61.1 Retroviral matrix proteins
View Download 0.406 a.133.1 Phospholipase A2, PLA2
View Download 0.399 a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.397 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.394 a.22.1 Histone-fold
View Download 0.380 d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.378 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.375 a.24.3 Cytochromes
View Download 0.371 b.60.1 Lipocalins
View Download 0.371 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.367 a.24.3 Cytochromes
View Download 0.365 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.363 d.110.3 PYP-like sensor domain (PAS domain)
View Download 0.358 a.74.1 Cyclin-like
View Download 0.351 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.348 a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.344 a.74.1 Cyclin-like
View Download 0.339 a.72.1 Functional domain of the splicing factor Prp18
View Download 0.333 b.123.1 Hypothetical protein TM1070
View Download 0.332 a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.327 c.55.2 Creatinase/prolidase N-terminal domain
View Download 0.326 d.110.4 SNARE-like
View Download 0.325 a.19.1 Fertilization protein
View Download 0.322 d.110.3 PYP-like sensor domain (PAS domain)
View Download 0.316 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.315 d.58.26 GHMP Kinase, C-terminal domain
View Download 0.314 c.95.1 Thiolase-like
View Download 0.308 a.4.5 "Winged helix" DNA-binding domain
View Download 0.305 a.1.1 Globin-like
View Download 0.298 a.126.1 Serum albumin-like
View Download 0.297 a.19.1 Fertilization protein
View Download 0.296 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.295 b.118.1 FAS1 domain
View Download 0.294 a.149.1 RNase III endonuclease catalytic domain
View Download 0.288 a.1.1 Globin-like
View Download 0.288 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.286 a.75.1 Ribosomal protein S7
View Download 0.282 d.82.2 Frataxin-like
View Download 0.282 a.4.5 "Winged helix" DNA-binding domain
View Download 0.282 a.39.1 EF-hand
View Download 0.278 a.4.5 "Winged helix" DNA-binding domain
View Download 0.273 a.1.1 Globin-like
View Download 0.272 c.47.1 Thioredoxin-like
View Download 0.271 d.21.1 Diaminopimelate epimerase-like
View Download 0.269 d.82.2 Frataxin-like
View Download 0.267 a.61.1 Retroviral matrix proteins
View Download 0.264 a.11.2 Second domain of FERM
View Download 0.264 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.256 b.118.1 FAS1 domain
View Download 0.254 a.4.5 "Winged helix" DNA-binding domain
View Download 0.253 a.4.1 Homeodomain-like
View Download 0.251 a.24.15 FAD-dependent thiol oxidase
View Download 0.249 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.247 a.74.1 Cyclin-like
View Download 0.244 a.1.1 Globin-like
View Download 0.237 b.7.4 Rab geranylgeranyltransferase alpha-subunit, insert domain
View Download 0.234 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.233 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.229 a.64.1 Saposin
View Download 0.225 a.63.1 Apolipophorin-III
View Download 0.223 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.222 a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.221 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.220 d.93.1 SH2 domain
View Download 0.217 d.168.1 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
View Download 0.214 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.203 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.202 a.61.1 Retroviral matrix proteins
View Download 0.201 d.58.33 Formylmethanofuran:tetrahydromethanopterin formyltransferase


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle