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View Structure Prediction Details

Protein: ECM25
Organism: Saccharomyces cerevisiae
Length: 599 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ECM25.

Description E-value Query
Range		 Subject
Range
ECM25_YEAST - Protein ECM25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM25 PE=1 SV=2
gi|164375555 - gi|164375555|gb|ABY52944.1| cell wall protein [Saccharomyces pastorianus]
ECM25 - Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor...
 0.0 [1..599] [1..599]
gi|124376166, gi... - gi|31317220|ref|NP_851851.1| PRR5-ARHGAP8 fusion protein [Homo sapiens], gi|14276191|gb|AAK58136.1|A...
 5.0E-96 [14..398] [61..461]
gi|13879250 - gi|13879250|gb|AAH06592.1| Arhgap1 protein [Mus musculus]
 7.0E-95 [14..360] [75..432]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-94 [14..364] [98..459]
gi|220953078 - gi|220953078|gb|ACL89082.1| RhoGAP68F-PA [synthetic construct]
RhoGAP68F-PA, FB... - The gene RhoGAP68F is referred to in FlyBase by the symbol Dmel\RhoGAP68F (CG6811, FBgn0036257). It ...
 2.0E-74 [11..359] [100..464]

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Predicted Domain #1
Region A:
Residues: [1-133] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIDINVNNIF FRSYSVDPNS GHAIYVFDST YLPASDEIGD KQVYDLLINA LMDRLVMKLP  60
   61 QAPYSLVIFS SGFSQRKISW VYGIKMFAKL PKETKFYLQK IFIVHESFFV RSVYQVISNA 120
  121 MNFNFLDSKD SQH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.604 0.125 cellular cell wall organization a.133.1 Phospholipase A2, PLA2
View Download 0.637 0.043 cellular cell wall organization c.95.1 Thiolase-like
View Download 0.791 0.029 cellular cell wall organization d.198.1 Type III secretory system chaperone
View Download 0.651 0.003 cellular cell wall organization f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.618 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.601 N/A N/A a.3.1 Cytochrome c
View Download 0.588 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.580 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.580 N/A N/A c.23.5 Flavoproteins
View Download 0.579 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.574 N/A N/A d.198.1 Type III secretory system chaperone
View Download 0.532 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.524 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.508 N/A N/A d.13.1 HIT-like
View Download 0.502 N/A N/A c.23.1 CheY-like
View Download 0.481 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.479 N/A N/A d.198.1 Type III secretory system chaperone
View Download 0.477 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.469 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.467 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.457 N/A N/A c.97.1 Cytidine deaminase-like
View Download 0.453 N/A N/A d.13.1 HIT-like
View Download 0.445 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.441 N/A N/A d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.438 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.438 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.429 N/A N/A d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.429 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.424 N/A N/A a.1.1 Globin-like
View Download 0.421 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.410 N/A N/A a.74.1 Cyclin-like
View Download 0.393 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.391 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.390 N/A N/A d.92.1 Metalloproteases ("zincins"), catalytic domain
View Download 0.387 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.387 N/A N/A a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.381 N/A N/A c.97.1 Cytidine deaminase-like
View Download 0.379 N/A N/A b.16.1 Ecotin, trypsin inhibitor
View Download 0.374 N/A N/A a.118.8 TPR-like
View Download 0.373 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.372 N/A N/A c.23.3 Hypothetical protein MTH538
View Download 0.369 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.368 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.365 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.362 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.361 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.358 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.356 N/A N/A d.38.1 Thioesterase/thiol ester dehydrase-isomerase
View Download 0.352 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.351 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.351 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.348 N/A N/A a.74.1 Cyclin-like
View Download 0.340 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.340 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.324 N/A N/A d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.323 N/A N/A a.1.1 Globin-like
View Download 0.317 N/A N/A d.185.1 LuxS/MPP-like metallohydrolase
View Download 0.316 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.311 N/A N/A c.47.1 Thioredoxin-like
View Download 0.305 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.303 N/A N/A d.21.1 Diaminopimelate epimerase-like
View Download 0.303 N/A N/A a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.301 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.300 N/A N/A f.31.1 Photosystem I reaction center subunit XI, PsaL
View Download 0.300 N/A N/A d.185.1 LuxS/MPP-like metallohydrolase
View Download 0.299 N/A N/A d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.297 N/A N/A a.47.2 t-snare proteins
View Download 0.295 N/A N/A a.26.1 4-helical cytokines
View Download 0.292 N/A N/A c.116.1 alpha/beta knot
View Download 0.290 N/A N/A a.87.1 DBL homology domain (DH-domain)
View Download 0.289 N/A N/A b.61.1 Avidin/streptavidin
View Download 0.281 N/A N/A d.65.1 Hedgehog/DD-pepidase
View Download 0.279 N/A N/A d.13.1 HIT-like
View Download 0.278 N/A N/A a.26.1 4-helical cytokines
View Download 0.277 N/A N/A a.1.1 Globin-like
View Download 0.267 N/A N/A a.7.1 Spectrin repeat
View Download 0.264 N/A N/A d.151.1 DNase I-like
View Download 0.262 N/A N/A d.110.5 Pheromone-binding domain of LuxR-like quorum-sensing transcription factors
View Download 0.260 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.258 N/A N/A d.13.1 HIT-like
View Download 0.258 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.257 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.253 N/A N/A c.95.1 Thiolase-like
View Download 0.252 N/A N/A c.51.4 Maf/Ham1
View Download 0.252 N/A N/A a.63.1 Apolipophorin-III
View Download 0.251 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.249 N/A N/A a.7.1 Spectrin repeat
View Download 0.248 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.244 N/A N/A a.1.1 Globin-like
View Download 0.243 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.241 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.238 N/A N/A b.7.4 Rab geranylgeranyltransferase alpha-subunit, insert domain
View Download 0.235 N/A N/A d.52.7 Ribosome-binding factor A, RbfA
View Download 0.233 N/A N/A a.39.1 EF-hand
View Download 0.230 N/A N/A d.41.4 Ribosomal protein L10e
View Download 0.230 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.230 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.228 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.227 N/A N/A d.173.1 Methionine synthase activation domain-like
View Download 0.226 N/A N/A a.26.1 4-helical cytokines
View Download 0.224 N/A N/A d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.218 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.215 N/A N/A d.13.2 Rotavirus NSP2 fragment, C-terminal domain
View Download 0.212 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.210 N/A N/A d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.207 N/A N/A c.61.1 PRTase-like
View Download 0.207 N/A N/A a.54.1 Domain of early E2A DNA-binding protein, ADDBP
View Download 0.206 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.206 N/A N/A a.75.1 Ribosomal protein S7
View Download 0.204 N/A N/A a.158.1 F-box domain
View Download 0.204 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.204 N/A N/A d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.204 N/A N/A d.58.46 eEF1-gamma domain
View Download 0.203 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.201 N/A N/A d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.201 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.200 N/A N/A a.2.3 Chaperone J-domain

Predicted functions:

Term Confidence Notes
binding 1.66936642189191 bayes_pls_golite062009
protein binding 0.602166427548399 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [134-259] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFPSLVHVLD LTSLSELIDI TRLRISLNVY LYDYQIREHI NVPEEYYNRL TPLAIRQYRQ  60
   61 LVFDKIFKKL QNDALLCELI FQKPGNYKKV NIFLDIIKRN NYIDLSQWDI YSLASVWLNY 120
  121 FIKNKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.522879
Match: 1rgp__
Description: p50 RhoGAP domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleoside-triphosphatase regulator activity 2.43743506044906 bayes_pls_golite062009
GTPase regulator activity 2.41587723604351 bayes_pls_golite062009
enzyme regulator activity 2.31135086896701 bayes_pls_golite062009
GTPase activator activity 2.15573543632895 bayes_pls_golite062009
enzyme activator activity 2.13776259591853 bayes_pls_golite062009
small GTPase regulator activity 1.99641315605345 bayes_pls_golite062009
Ras GTPase activator activity 1.8516163173153 bayes_pls_golite062009
Rho GTPase activator activity 1.661551260799 bayes_pls_golite062009
binding 1.47992835441063 bayes_pls_golite062009
protein binding 1.42235437592444 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [260-364] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPLIPIELIP LPIVDDLKFT SETFRKIIKF NQYQDLFMVI IPFFNRIIAH GESTKHDSRT  60
   61 LSKALTPALC KEKLSMMTND RLAIGSRYIK NLLDFFPEIA KEISS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.522879
Match: 1rgp__
Description: p50 RhoGAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [365-599] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPSSVSSSST IPVLPKPRKS SPTRYSELGC LTLPRSRSPS PQRSVTSPTY TPVALQNTPV  60
   61 LKPKSSSRNV SSPSFNAKPP LPIKAVTRPQ LSLTSNSNTD LALASSSTDT LSSPTKTPSA 120
  121 DSLPLSNSST DLTISDNIKE MVKDEPAKDK NSVETDIFVQ QFESLTLVQN AKIKKFDKEL 180
  181 QEKKKKNETT SKTADKFSQK GYSDIKASNK VSRLAALYEE RLQGLQVMNE MKQRW

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.42
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle