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View Structure Prediction Details

Protein: VPS35
Organism: Saccharomyces cerevisiae
Length: 944 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS35.

Description E-value Query
Range
Subject
Range
gi|253435 - gi|253435|gb|AAB22844.1| Vps35p [Saccharomyces cerevisiae]
1383.0 [0..1] [944..1]
gi|9622850 - gi|9622850|gb|AAF89953.1|AF175265_1 vacuolar sorting protein 35 [Homo sapiens]
1105.0 [0..8] [856..17]
VPS35_MOUSE - Vacuolar protein sorting-associated protein 35 OS=Mus musculus GN=Vps35 PE=1 SV=1
1104.0 [0..8] [856..17]
gi|47212853 - gi|47212853|emb|CAF93242.1| unnamed protein product [Tetraodon nigroviridis]
1104.0 [0..8] [856..436]
gi|67970894 - gi|67970894|dbj|BAE01789.1| unnamed protein product [Macaca fascicularis]
1103.0 [0..8] [856..17]

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Predicted Domain #1
Region A:
Residues: [1-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYADSPENA IAVIKQRTAL MNRCLSQHKL MESLQHTSIM LTELRNPNLS PKKYYELYVI  60
   61 IFDSLTNLST YLIENHPQNH HLADLYELVQ YTGNVVPRLY LMITVGTSYL TFNEAPKKEI 120
  121 LKDMIEMCRG VQNPIRGLFL RYYLSQRTKE LLPEDDPSFN SQFIMNNFIE MNKLWVRLQH 180
  181 QGPLRERETR TRERKELQIL VGSQLVRLSQ IIDDNFQMYK QDILPTILEQ VIQCRDLVSQ 240
  241 EYLLDVICQV FADEFHLKTL DTLLQTTLHL NPD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [274-892]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSINKIVLTL VDRLNDYVTR QLEDDPNATS TNAYLDMDVF GTFWDYLTVL NHERPDLSLQ  60
   61 QFIPLVESVI VLSLKWYPNN FDNLNKLFEL VLQKTKDYGQ KNISLESEHL FLVLLSFQNS 120
  121 KLQLTSSTTA PPNSPVTSKK HFIFQLISQC QAYKNILALQ SISLQKKVVN EIIDILMDRE 180
  181 VEEMADNDSE SKLHPPGHSA YLVIEDKLQV QRLLSICEPL IISRSGPPAN VASSDTNVDE 240
  241 VFFNRHDEEE SWILDPIQEK LAHLIHWIMN TTSRKQTMKN KIQFSLEAQL EILLLIKSSF 300
  301 IKGGINVKYT FPAIITNFWK LMRKCRMIQE YLLKKRPDNK TLLSHYSNLL KQMFKFVSRC 360
  361 INDIFNSCNN SCTDLILKLN LQCAILADQL QLNEISYDFF SQAFTIFEES LSDSKTQLQA 420
  421 LIYIAQSLQK TRSLYKEAYY DSLIVRCTLH GSKLLKKQDQ CRAVYLCSHL WWATEISNIG 480
  481 EEEGITDNFY RDGKRVLECL QRSLRVADSI MDNEQSCELM VEILNRCLYY FIHGDESETH 540
  541 ISIKYINGLI ELIKTNLKSL KLEDNSASMI TNSISDLHIT GENNVKASSN ADDGSVITDK 600
  601 ESNVAIGSDG TYIQLNTLN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [893-944]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSTLIRGVV ATASGSKLLH QLKYIPIHHF RRTCEYIESQ REVDDRFKVI YV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.565 a.4.5 "Winged helix" DNA-binding domain
View Download 0.458 a.4.5 "Winged helix" DNA-binding domain
View Download 0.457 a.5.2 UBA-like
View Download 0.428 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.424 a.5.2 UBA-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle