YRC Public Data Repository - Protein Structure Prediction

Protein:	GCD14
Organism:	Saccharomyces cerevisiae
Length:	383 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCD14.

Description	E-value	Query Range	Subject Range
TRM61_ASHGO - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Ashbya gossypii (strain ATCC 10... TRM61_ASHGO - tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 OS=Ashbya gossypii GN=TRM61 PE=3 SV=1	271.0	[0..6]	[378..4]
TRM61_KLULA - tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 OS=Kluyveromyces lactis GN=TRM61 PE=3... TRM61_KLULA - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Kluyveromyces lactis (strain AT...	263.0	[0..6]	[378..4]
TRM61_CANGA - tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 OS=Candida glabrata GN=TRM61 PE=3 SV=... TRM61_CANGA - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Candida glabrata (strain ATCC 2...	259.0	[0..6]	[376..5]
cpd1 - tRNA (m1A) methyltransferase complex subunit Cpd1 TRM61_SCHPO - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trm61 OS=Schizosaccharomyces pombe (stra...	242.0	[0..6]	[361..3]
gi\|21220147, gi\|... - gi\|6119693\|emb\|CAB59504.1\| conserved hypothetical protein SCI41.34c [Streptomyces coelicolor A3(2)],...	224.0	[0..3]	[314..4]
gi\|29610338, gi\|... - gi\|29833216\|ref\|NP_827850.1\| hypothetical protein SAV_6674 [Streptomyces avermitilis MA-4680], gi\|29...	220.0	[0..3]	[314..4]
gi\|28827644, gi\|... - gi\|28827644\|gb\|AAO50666.1\| unknown protein [Arabidopsis thaliana], gi\|28393527\|gb\|AAO42184.1\| unknow...	219.0	[0..2]	[361..6]
TRM61_DEBHA - tRNA - Debaryomyces hansenii (Yeast) (Torulaspora hansenii) gi\|50413274, gi\|... - gi\|50413274\|ref\|XP_457237.1\| hypothetical protein DEHA0B06380g [Debaryomyces hansenii CBS767], gi\|49...	215.0	[0..5]	[362..2]
TRM61_CANAL - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Candida albicans (strain SC5314... TRM61_CANAL - tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 OS=Candida albicans GN=TRM61 PE=3 SV=...	209.0	[0..5]	[364..2]

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Predicted Domain #1

Region A:
Residues: [1-78]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNCFSGYK DLIKEGDLTL IWVSRDNIKP VRMHSEEVFN TRYGSFPHKD IIGKPYGSQI  60
   61 AIRTKGSNKF AFVHVLQP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	137.457575
Match:	1i9gA
Description:	Probable methyltransferase Rv2118c
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [79-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPELWTLSLP HRTQIVYTPD SSYIMQRLNC SPHSRVIEAG TGSGSFSHAF ARSVGHLFSF  60
   61 EFHHIRYEQA LEEFKEHGLI DDNVTITHRD VCQGGFLIKK GDTTSYEFGN NETAASLNAN 120
  121 VVFLDLPAPW DAIPHLDSVI SVDEKVGLCC FSPCIEQVDK TLDVLEKYGW TDVEMVEIQG 180
  181 RQYESRRQMV RSLNDALERL RDIKRHKLQG VERRKRMFNN TIDSNDEKVG KRNE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	137.457575
Match:	1i9gA
Description:	Probable methyltransferase Rv2118c
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [313-383]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGVPLTEKAK FNPFGKGSRI KEGDSNYKWK EVTKMEAEIK SHTSYLTFAF KVVNRSRDDE  60
   61 KVNEILRSTE K

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.599	d.224.1	SufE-like
View	Download	0.597	a.4.1	Homeodomain-like
View	Download	0.562	a.56.1	CO dehydrogenase ISP C-domain like
View	Download	0.546	a.56.1	CO dehydrogenase ISP C-domain like
View	Download	0.535	a.4.1	Homeodomain-like
View	Download	0.522	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.488	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits