YRC Public Data Repository - Protein Structure Prediction

Protein:	SET4
Organism:	Saccharomyces cerevisiae
Length:	560 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SET4.

Description	E-value	Query Range	Subject Range
SET4 - Protein of unknown function, contains a SET domain SET4_YEAST - SET domain-containing protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SET4 PE=...	0.0	[1..560]	[1..560]
SET1_SCHPO - Histone-lysine N-methyltransferase, H3 lysine-4 specific OS=Schizosaccharomyces pombe (strain 972 / ... set1 - histone lysine methyltransferase Set1	9.0E-60	[10..497]	[474..917]
gi\|168267342, gi... - gi\|61361080\|gb\|AAX41986.1\| enhancer of zeste-like 1 [synthetic construct], gi\|168267342\|dbj\|BAG09727... EZH1 - enhancer of zeste homolog 1 (Drosophila) gi\|114667137, gi... - gi\|114667139\|ref\|XP_511519.2\| PREDICTED: enhancer of zeste homolog 1 isoform 7 [Pan troglodytes], gi...	3.0E-59	[70..480]	[329..733]
EZH1_MOUSE - Histone-lysine N-methyltransferase EZH1 OS=Mus musculus GN=Ezh1 PE=1 SV=1	4.0E-59	[70..480]	[329..733]
EZH2A_XENLA - Histone-lysine N-methyltransferase EZH2 OS=Xenopus laevis GN=ezh2-a PE=2 SV=1	1.0E-54	[69..480]	[317..734]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-54	[44..492]	[722..1162]
gi\|16605541 - gi\|16605541\|emb\|CAC86146.1\| EZH2 homolog [Tetraodon nigroviridis]	6.0E-54	[70..482]	[331..747]

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Predicted Domain #1

Region A:
Residues: [1-95]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSPESLSSR HIRQGRTYTT TDKVISRSSS YSSNSSMSKD YGDHTPLSVS SAASETLPSP  60
   61 QYMPIRTFNT MPTAGPTPLH LFQNDRGIFN HHSSS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [96-245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSKTASTNK RGIAAAVALA TAATIPFPLK KQNQDDNSKV SVTHNESSKE NKITPSMRAE  60
   61 DNKPKNGCIC GSSDSKDELF IQCNKCKTWQ HKLCYAFKKS DPIKRDFVCK RCDSDTKVQV 120
  121 NQVKPMIFPR KMGDERLFQF SSIVTTSASN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.045757
Match:	1fp0A_
Description:	Nuclear corepressor KAP-1 (TIF-1beta)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.654291041691191	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [246-560]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNQHQQSVNN IEEQPKKRQL HYTAPTTENS NSIRKKLRQE KLVVSSHFLK PLLNEVSSSN  60
   61 DTEFKAITIS EYKDKYVKMF IDNHYDDDWV VCSNWESSRS ADIEVRKSSN ERDFGVFAAD 120
  121 SCVKGELIQE YLGKIDFQKN YQTDPNNDYR LMGTTKPKVL FHPHWPLYID SRETGGLTRY 180
  181 IRRSCEPNVE LVTVRPLDEK PRGDNDCRVK FVLRAIRDIR KGEEISVEWQ WDLRNPIWEI 240
  241 INASKDLDSL PDPDKFWLMG SIKTILTNCD CACGYLGHNC PITKIKNFSE EFMRNTKESL 300
  301 SNKSYFNTIM HNCKP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: