YRC Public Data Repository - Protein Structure Prediction

Protein:	GSH1
Organism:	Saccharomyces cerevisiae
Length:	678 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GSH1.

Description	E-value	Query Range	Subject Range
GSH1_YEAST - Glutamate--cysteine ligase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GSH1 PE=1 SV=... GSH1 - Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expres... gi\|190409400 - gi\|190409400\|gb\|EDV12665.1\| gamma-glutamylcysteine synthetase [Saccharomyces cerevisiae RM11-1a]	0.0	[1..678]	[1..678]
GSH1_MOUSE - Glutamate--cysteine ligase catalytic subunit OS=Mus musculus GN=Gclc PE=1 SV=4	0.0	[1..661]	[1..621]
GSH1_RAT - Glutamate--cysteine ligase catalytic subunit OS=Rattus norvegicus GN=Gclc PE=1 SV=2	0.0	[1..661]	[1..621]
GCLC - glutamate-cysteine ligase, catalytic subunit gi\|190691599, gi... - gi\|190691599\|gb\|ACE87574.1\| glutamate-cysteine ligase, catalytic subunit protein [synthetic construc...	0.0	[1..661]	[1..621]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..649]	[1..613]
gi\|971592 - gi\|971592\|emb\|CAA59379.1\| gamma-glutamylcysteine synthetase [Schizosaccharomyces pombe]	0.0	[1..649]	[1..614]
GSH1_ONCVO - Glutamate--cysteine ligase OS=Onchocerca volvulus GN=gcs-1 PE=2 SV=2	0.0	[1..660]	[1..623]

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Predicted Domain #1

Region A:
Residues: [1-237]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLALGTPL QWFESRTYNE HIRDEGIEQL LYIFQAAGKR DNDPLFWGDE LEYMVVDFDD  60
   61 KERNSMLDVC HDKILTELNM EDSSLCEAND VSFHPEYGRY MLEATPASPY LNYVGSYVEV 120
  121 NMQKRRAIAE YKLSEYARQD SKNNLHVGSR SVPLTLTVFP RMGCPDFINI KDPWNHKNAA 180
  181 SRSLFLPDEV INRHVRFPNL TASIRTRRGE KVCMNVPMYK DIATPETDDS IYDRDWF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [238-678]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPEDKEAKLA SKPGFIYMDS MGFGMGCSCL QVTFQAPNIN KARYLYDALV NFAPIMLAFS  60
   61 AAAPAFKGWL ADQDVRWNVI SGAVDDRTPK ERGVAPLLPK YNKNGFGGIA KDVQDKVLEI 120
  121 PKSRYSSVDL FLGGSKFFNR TYNDTNVPIN EKVLGRLLEN DKAPLDYDLA KHFAHLYIRD 180
  181 PVSTFEELLN QDNKTSSNHF ENIQSTNWQT LRFKPPTQQA TPDKKDSPGW RVEFRPFEVQ 240
  241 LLDFENAAYS VLIYLIVDSI LTFSDNINAY IHMSKVWENM KIAHHRDAIL FEKFHWKKSF 300
  301 RNDTDVETED YSISEIFHNP ENGIFPQFVT PILCQKGFVT KDWKELKHSS KHERLYYYLK 360
  361 LISDRASGEL PTTAKFFRNF VLQHPDYKHD SKISKSINYD LLSTCDRLTH LDDSKGELTS 420
  421 FLGAEIAEYV KKNKPSIESK C

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	300.721246
Match:	PF03074
Description:	Glutamate-cysteine ligase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits