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View Structure Prediction Details

Protein: NET1
Organism: Saccharomyces cerevisiae
Length: 1189 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NET1.

Description E-value Query
Range
Subject
Range
NET1 - Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase e...
NET1_YEAST - Nucleolar protein NET1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NET1 PE=1 SV=1
8.0E-98 [1..1189] [1..1189]
gi|463250 - gi|463250|emb|CAA83229.1| Neurofilament protein, high molecular weight subunit (NF-H) [Mus musculus]
3.0E-50 [371..1172] [293..1071]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-50 [371..1172] [294..1072]
gi|205686 - gi|205686|gb|AAA41695.1| heavy neurofilament subunit
2.0E-48 [371..1172] [27..795]
gi|16554449, gi|... - gi|16554449|ref|NP_003377.1| zonadhesin isoform 3 [Homo sapiens], gi|12667414|gb|AAK01433.1|AF332977...
2.0E-47 [708..1183] [535..1016]

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Predicted Domain #1
Region A:
Residues: [1-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYKLQVVLVP PSLQATMPIQ FGYGPTIAES SQLLPNRTNM AQSAGDASLQ YANLRSANVS  60
   61 FTPSYFNQSR FRKFLLFTKP TNTLLNLSDE IIDKCEKMYP SLQEDIEILS LQDNSGCDLD 120
  121 PDFLVKDVFN VNNIVRVILK NEIDLDDSAP VSLYKSVKRS KLNNGSPQSV QPQQQIPSSS 180
  181 GVLRIAKKRP PTGTTTTTTI RSATNGSMRV STPLARQIYP PPSSKI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [227-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSNNSDDEDE DIGERSFLPP PTQPQSPPIR ISSGIDAGKK IKSSIVEEDI VSRSATVDPD  60
   61 KTKQQRLLSG 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [297-657]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPIMSTMTPN RVTLTGQRVV SEHAHKNELV FSASASSSSF ANGGTAAVTA QDINRKPPVT  60
   61 TPRITSGMLK IPEPRISEIE KELKEGPSSP ASILPAKAAK IPMKKPYLEN GENYESDDSS 120
  121 SSENQETPET EPHSKASLQR SQSSIADNNG SPVKNSPLGD AMPHNVHLAE LPKASNTSIT 180
  181 KSSNGESWGK QQEHQPPRKS SLETIVEKKS QAEPSGIVEP KRMTNFLDDN QVREKEDTND 240
  241 KLLEKEILPT IPHNDQPILA SSDKSNGTLK SLAGKVSSNN NASKEDGTII NGTIEDDGND 300
  301 NDEVDTTVRI VPQDSDSSSF PKSDLFKMIE GDDTDLPQWF KGKNSRTSGN SKNSKPYTTV 360
  361 L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.154902
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [658-689]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKDIDNSKPD PRNILPQRTP RSAAKRAAQL LA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [912-985]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEKEDSKSKQ VSQKKLKMTD HLKEGNVQLP KPSANDKLKD LKAKFTNSKT LVPPGIISNE  60
   61 KNNSSANDDD SSSS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.65
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #5
Region A:
Residues: [690-762]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAKKNEVPQK STEDSSSAAS TDDESESGIE TDFSSDDDFK RKNMSVPNNG PKDISLHSLK  60
   61 GSVVPVKDSK IIN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.65
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #6
Region A:
Residues: [763-841]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEVDEERNDK RDSQKKSAVS ESSVTNSKIS EQMAKSFYPN SNKKQNEATK VETKPATQAS  60
   61 SFPVVGGSPS VATKGTTSF

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.65
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #7
Region A:
Residues: [842-911]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEEGNRKNVK TKAKNESAQI DRQQKETTSR VADLKSANIG GEDLNKKAEG SKEPEKASAN  60
   61 IQDANDKNNS 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.65
Match: 1l8mA
Description: No description for 1l8mA was found.

Predicted Domain #8
Region A:
Residues: [986-1189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSTEDESSS SSSSSDEETS TSRKARRVVV NTPREPVRSS SKIEAPSPSV NKKINATPDK  60
   61 IPVTQLMDMS SPPSVKSKTT SNPSSILHDL PRKVRPSLSS LSDLVSRGIP DVKEKTSKSN 120
  121 EKSQTKAPSS SDDESSSDSD SNSSSDSVSD SSSDSKSESD SDDSGDSSDD GKSFISAKSA 180
  181 SAALGKKKKP SGGFASLIKD FKKK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.81
Match: 1deqA
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle